Influence of Omega-3 Fatty Acid-Rich Fish Oils on Hyperlipidemia: Effect of Eel, Sardine, Trout, and Cod Oils on Hyperlipidemic Mice

Abstract

Dyslipidemia is one of the most important cardiovascular disease (CVD) risk factors. Polyunsaturated fatty acids (FAs), and especially omega-3 FAs, could significantly contribute to the management of dyslipidemia and the prevention of CVD. The anti-hyperlipidemic effect of selected fish oils (eel, sardine, trout, cod liver) was comparatively evaluated in a high fat diet (HFD)-fed mouse model. At the end of 30 days on the HFD, all animals were hyperlipidemic and were switched to a diet consisting of 90% standard rodent chow plus 10% of oil from eel, sardine, cod liver, or trout. At the end of 60 days on these diets, blood glucose, total blood cholesterol, triglycerides (TGs), and high density lipoprotein (HDL) were quantitated. All diets, except sardine and standard rodent chow, showed statistically significant decreases in blood glucose from day 30 to 90. Total blood cholesterol decreased in all diets except the HFD group, which was continued on this diet until the end of the study. Eel and cod liver oil diets showed significant decreases in TGs. All dietary groups showed a decrease in HDL, but only the trout and standard chow groups exhibited statistically significant decreases. The fish oils tested here for effects on hyperlipidemia vary in per cent of omega-3 FAs and omega-6/-3 FA ratios as determined by gas chromatography Overall, smoked eel was the best source of omega-3 FA, with a balance of omega-6 FA, that ameliorated HFD-induced mixed hyperlipidemia.

Protective mechanisms of a microbial oil against hypercholesterolemia: evidence from a zebrafish model

“…With their differential action on transcription factors, the omega-3 fatty acids, EPA and DHA may have independent positive effects on the cardiovascular system ( 71 ). Most studies on human and animal models investigated the effects of omega-3 fatty acids in fish oil on TAGs and lipoproteins ( 72 , 73 ). Schizochytrium sp.…”

Karakterisasi Nanoemulsi Minyak Tulang Ikan Sidat dengan Ekstrak Daun Salam dan Uji Aktivitas Antihiperlipidemia

“…Minyak tulang ikan sidat dapat diformulasi menjadi nanoemulsi yang baik karena tersusun dari asam lemak rantai hidrokarbon menengah dan panjang (Beandrade, 2018;Aprilya et al, 2021). Penelitian sebelumnya telah dilakukan diantaranya adalah karakterisasi nanoemulsi dengan pembawa minyak ikan dan zat aktif dari bahan alam (Zhong et al, 2018;Djamil et al, 2020) dan uji antihiperlipidemia pada minyak ikan sidat (Kontostathi et al, 2021).…”

Different Sources of Omega-3 Fatty Acid Supplementation vs. Blood Lipid Profiles—A Study on a Rat Model

“…Numerous strategies have been developed to control dyslipidemia, and they include changes in lifestyle, e.g., diet, physical exercise or pharmacological means [1]. However, a key role in dyslipidemia management and CVD risk prevention is attributed to nutritional factors [5], and supplementation with omega-3 fatty acids is considered to be one of the most significant approaches in this range. Dietary supplements other than PUFAs (polyunsaturated fatty acids) can be used to prevent dyslipidemia or to support its treatment, and they include, for example, plant sterols or stanols, berberine, red yeast rice, garlic, resveratrol, sour tea, green tea, curcuminoids or anthocyanins [6], policosanol, niacin, tocotrienols, pantethine, gugulipids [7] and probiotics [8].…”