Influence of one-week hindlimb suspension and intermittent high load exercise on rat muscles

Herbert, Maria; Roy, Roland R.; Edgerton, V. Reggie

doi:10.1016/0014-4886(88)90093-3

Cited by 98 publications

(80 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The extent of atrophy with the hindlimb unweighting model seems to be dependent on the muscle (e.g. plantaris, EDL and gastrocnemius) and duration of inactivity (number of weeks of hindlimb unweighting) (Gardetto et al, 1989;Herbert et al, 1988;Hurst and Fitts, 2003;Sandmann et al, 1998;Simard and Lacaille, 1988). The 5%-23% decrease in fiber diameter in the current study is consistent with previous studies investigating type II fibers from adult, old and very old rats for a similar duration (Gardetto et al, 1989;Simard and Lacaille, 1988).…”

Section: Treadmill Exercise Induced Changessupporting

confidence: 90%

“…Although exercise benefits have been noted, the exercises are either too aggressive or not suited to the very old rat that might be susceptible to muscle damage (Herbert et al, 1988;Pierotti et al, 1990;Linderman et al, 1994). One study that investigated isometric exercise in rats, an exercise that does not cause muscle damage, did not prevent the inactivity induced decline in gastrocnemius muscle function (Hurst and Fitts, 2003).…”

Section: Treadmill Exercise Induced Changesmentioning

confidence: 99%

“…Exercise training partially attenuates the deleterious effects of inactivity (Alley and Thompson, 1997;Brown and Hasser, 1995;Brown and Taylor, 2005;Herbert et al, 1988;Hurst and Fitts, 2003;Sandmann et al, 1998;Thompson, 2002). Several studies have focused on preventing the inactivity-induced skeletal muscle weakness by examining the benefits of intensive exercise protocols in adult aged rats.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have focused on preventing the inactivity-induced skeletal muscle weakness by examining the benefits of intensive exercise protocols in adult aged rats. These exercise protocols included a daily short-duration high-load exercise training program, resistance training, conditioning and isometric exercises (Brown and Taylor, 2005;Herbert et al, 1988;Hurst and Fitts, 2003;Pierotti et al, 1990). Although the intensive exercise protocols were beneficial to varying degrees to the muscles, these rigorous protocols may not be appropriate for muscles of older rats due to the risk of muscle injury.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Age-dependent effects of treadmill exercise during a period of inactivity

Arora

Husom

Ferrington

et al. 2008

Experimental Gerontology

View full text Add to dashboard Cite

The objective of this study was to investigate the effect of a treadmill exercise protocol to prevent muscle weakness, atrophy and alterations in calcium regulation in adult, old and very old rats. Adult (7-12 months), old (29-30 months) and very old (34-36 months) F344BNF 1 rats were randomly assigned to weight bearing (WB), weight bearing exercise (WBX), non-weight bearing (NWB) and non-weight bearing exercise (NWBX) groups. The WB group was considered the sedentary-control animals. NWB rats were hindlimb unweighted for 14 days. WBX and NWBX groups were exercised on a treadmill for approximately fifteen minutes four times daily. The contractile properties [diameter, peak active force (P 0 ), specific tension (P 0 /CSA)] of single myosin heavy chain type II fibers and Ca regulation [Ca +2 dependent ATPase activity] were determined. Fiber diameter reduced by 24% in the very old rats with NWB. P 0 and P 0 /CSA declined in the young adult and very old rats with NWB. NWBX attenuated these changes in the young and very old rats. Ca +2 dependent ATPase activity increased with treadmill exercise during non-weight bearing in the young animals. In conclusion, the treadmill exercise is beneficial in attenuating the non-weight bearing induced changes in the individual MHC type II muscle fibers of the gastrocnemius muscle.

show abstract

Section: Treadmill Exercise Induced Changessupporting

confidence: 90%

Section: Treadmill Exercise Induced Changesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Age-dependent effects of treadmill exercise during a period of inactivity

Arora

Husom

Ferrington

et al. 2008

Experimental Gerontology

View full text Add to dashboard Cite

show abstract

“…Therefore, suspension disuse mainly affected the slow-twitch fiber. It was reported that the contraction time and half relaxation time of skeletal muscle decreased following hindlimb suspension (HERBERT et al, 1988). These results reflected the increase of fast-type myosin isozyme composition (TEMPLETON et al, 1988).…”

Section: Discussionmentioning

confidence: 75%

Ultrastructural and metabolic profiles on single muscle fibers of different types after hindlimb suspension in rats.

Takekura

Yoshioka

1989

Jpn.J.Physiol

View full text Add to dashboard Cite

Abstracts The relationships between ultrastructural and metabolic profiles in different types of single muscle fiber after hindlimb suspension in rats were examined. Glycolytic (lactate dehydrogenase, LDH; phosphofructokinase, PFK) and oxidative (succinate dehydrogenase, SDH; malate dehydrogenase, MDH) enzyme activities in extensor digitorum longus (EDL) and soleus (SOL) muscles were measured. Relative mitochondrial and lipid droplet volumes were also measured in single muscle fiber of different types. Glycolytic enzyme activity in EDL muscle and oxidative enzyme activity in soleus muscle decreased following suspension for 2 weeks. LDH and PFK activities in fast-twitch (FG, fast-twitch glycolytic; FOG, fast-twitch oxidative glycolytic) fibers and oxidative enzymes in FOG and FG fibers decreased following suspension. Relative mitochondrial volume decreased significantly in all types (SO, slow-twitch oxidative; FOG, and FG) of fibers following suspension. The mitochondrial volume in SO fiber of the control group was significantly (p <0.01) higher than that of suspended group; however, SDH and MDH activities were not different between the control and suspended groups. The structural and metabolic changes following hindlimb suspension were influenced by different factors, respectively. Changes in ultrastructural and metabolic profiles in response to the hindlimb suspension differed according to the type of fibers.

show abstract