Influence of oophorectomy on glycemia and lipidogram

Teixeira, Renan Kleber Costa; Feijó, Daniel Haber; Valente, Antônia Regiane Pereira Duarte; Carvalho, Luan Teles Ferreira de; Granhen, Hícaro Donato; Petroianu, Andy; Botelho, Nara Macedo

doi:10.1590/s0102-865020180050000003

Cited by 5 publications

(4 citation statements)

References 15 publications

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“…n for each group is in the column skeletal muscle of male mice predominate the estrogen receptor beta, that reduces the expression of the GLUT4 (Barros et al, 2006(Barros et al, , 2009. Different studies in female rats submitted to ovariectomy found that they have insulin resistance and glucose intolerance (Faulds et al, 2012;Kleber Costa Teixeira et al, 2018;Saengsirisuwan et al, 2009). Here, we show for the first time that glucose curve during GTT in 18-month-old female rats is similar to younger counterparts (Figure 2b,c).…”

Section: Discussionsupporting

confidence: 58%

Sex differences in body composition, metabolism‐related hormones, and energy homeostasis during aging in Wistar rats

et al. 2020

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Aging affects the body composition and balance of energy metabolism. Here, we collected in a single work several physiological parameters to show how aging and sex differences can influence energy homeostasis. Body mass index (BMI), Lee index, glucose tolerance, glycemia, and lipidogram in fasting were measured in male and female Wistar rats at the ages of 2, 6, 9, 12, and 18 months. We also measured the lipid profile, free fatty acids, glycerol, glycemia, leptin, adiponectin, insulin, corticosterone (CORT), prolactin (PRL), thyroid stimulated hormone, and triiodothyronine (T3) in 3‐ and 18‐month‐old rats of both sexes, fed ad libitum. Animals were classified as obese beginning at 2 months in males and 6 months in females. Aged male rats showed hyperglycemia and glucose intolerance compared to young males and old females. In the ad libitum condition, the 18‐month males presented higher serum levels of triglycerides, total cholesterol, and free fatty acids than females. The 18‐month‐old females had higher PRL and CORT concentration than males, but insulin and T3 were higher in 18‐month‐old males than females. Our work demonstrated that aging processes on energy metabolism in rats is sex specific, with a better lipid profile and glucose tolerance in aged females.

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Section: Discussionsupporting

confidence: 58%

Sex differences in body composition, metabolism‐related hormones, and energy homeostasis during aging in Wistar rats

et al. 2020

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“…However, in the groups without ERT, after 20 weeks postovariectomy LDL values were decreased compared to those at 10 weeks. In agreement with our results, Teixeira et al [75] found temporal variations in LDL, cholesterol, and HDL after ovariectomy. Thus, our results confirm that ovariectomy induces time-dependent lipid metabolic alterations.…”

Section: Metabolic Alterations Caused By Ovariectomy and The Effect O...supporting

confidence: 94%

Early Estrogen Replacement Therapy Attenuates Cardiac Dysfunction Caused by Aging and Ovariectomy in Female Wistar Rats

Ramírez-Hernández,

López-Sanchez,

Lezama-Martínez

et al. 2024

Front. Biosci. (Landmark Ed)

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Background: Cardiovascular diseases (CVDs) are the leading cause of women's mortality, linked to aging and reduced estrogen during menopause. Estrogen replacement therapy (ERT) is suggested for CVDs prevention. Yet, its timing initiation remains contentious. Thus, we aimed to evaluate the effect of early and late estrogen therapy on cardiac function and lipid metabolism in ovariectomized old female Wistar rats. Methods: Fifty randomized female Wistar rats were included in 5 groups (n = 10, 18 months old): (1) Sham, (2) 10 weeks post ovariectomy (Ovx-10 w), (3) 10 weeks post Ovx + early estrogen replacement therapy (Ovx 10 w-early ERT), (4) 20 weeks post Ovx (Ovx-20 w) and ( 5) Ovx 20 w-late ERT. Three days (early ERT) or 10 weeks (late ERT) after surgery 17-β estradiol was given (5 µg/kg/day), and 10 weeks after the start of ERT, we assessed cardiac function by echocardiography, electrocardiography, and cardiac catheterization. Estradiol, cholesterol, triglyceride (TG), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels were determined. Cardiac histology was performed with Masson's staining. Results: Ovariectomy (Ovx) increases left ventricle internal systolic diameter (0.4 vs 0.3 cm, *p = 0.020) and decreases shortening fraction (40 vs 54 %, *p = 0.030) regardless of therapy. ERT prevents the increase in left ventricle mass after 10 weeks post-Ovx and the ejection fractionreduction after 20 weeks. Lower P wave amplitudes (18.8 vs 24.2 ms, *p = 0.013) were found in the Ovx-20 w group. A longer duration of the QRS complex after 20 weeks post-Ovx with and without ERT was found (32.5 and 32.1 vs 28.3 ms, *p = 0.003; *p = 0.007). Diastolic blood pressure was higher 20 weeks post-Ovx (86 vs 76 mmHg, *p = 0.047), regardless of ERT. The left ventricle (LV) -dP/dt was decreased in Ovx groups without ERT (-750 vs -1320 mmHg, *p = 0.034). An increase in LV collagen deposition was found in the Ovx 10 w group vs Sham (9.58 vs 4.54 %, *p = 0.028). Early ERT avoids the increase in body weight, cholesterol and LDL caused by Ovx. Conclusions: Ovariectomy causes time-dependent alterations in lipid metabolism, morphology, electrical activity, and heart contractile function. Early but not late ERT prevents some of these effects.

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“…The ovariectomy itself resulted in an increase in triglyceride levels. The higher triglyceride levels could be associated with the lack of sex hormones such as in menopause 19 . After treating OVX animals with pilocarpine, there was a significant decrease in triglycerides in the 30 min (90.40 ± 21.58 mg/dL) and 90 min (54.60 ± 16.30 mg/dL) of SE onset, compared to CTR-OVX (214.50 ± 43.00 mg/dL) ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Hormonal and biochemical changes in female Proechimys guyannensis, an animal model of resistance to pilocarpine-induced status epilepticus

Sanabria

Bittencourt

Perosa

et al. 2020

Sci Rep

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The Amazon rodent Proechimys guyannensis is widely studied for hosting various pathogens, though rarely getting sick. Previous studies on male Proechimys have revealed an endogenous resistance to epilepsy. Here, we assess in female Proechimys, whether sex hormones and biochemical aspects can interfere with the induction of status epilepticus (SE). The lithium-pilocarpine ramp-up protocol was used to induce SE, and blood sera were collected at 30 and 90 min after SE, alongside brains, for biochemical, western blot and immunohistochemical analyses. Results from non-ovariectomised (NOVX) Proechimys were compared to ovariectomised (OVX) animals. Data from female Wistars were used as a positive control of SE inductions. SE latency was similar in NOVX, OVX, and female Wistars groups. However, the pilocarpine dose required to induce SE in Proechimys was higher (25- to 50-folds more). Despite a higher dose, Proechimys did not show strong SE like Wistars; they only reached stage 2 of the Racine scale. These data suggest that female Proechimys are resistant to SE induction. Glucose and progesterone levels increased at 30 min and returned to normal at 90 min after SE. A relevant fact because in humans and rodents, SE leads to hypoglycaemia after 30 min of SE and does not return to normal levels in a short time, a typical adverse effect of SE. In OVX animals, a decrease in GABAergic receptors within 90 min of SE may suggest that ovariectomy produces changes in the hippocampus, including a certain vulnerability to seizures. We speculate that progesterone and glucose increases form part of the compensatory mechanisms that provide resistance in Proechimys against SE induction.

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Influence of oophorectomy on glycemia and lipidogram

Abstract: Oophorectomy was related to dyslipidemia and insulin resistance, mainly after 50th days.

Cited by 5 publications

References 15 publications

Sex differences in body composition, metabolism‐related hormones, and energy homeostasis during aging in Wistar rats

Sex differences in body composition, metabolism‐related hormones, and energy homeostasis during aging in Wistar rats

Early Estrogen Replacement Therapy Attenuates Cardiac Dysfunction Caused by Aging and Ovariectomy in Female Wistar Rats

Hormonal and biochemical changes in female Proechimys guyannensis, an animal model of resistance to pilocarpine-induced status epilepticus

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