Influence of optic disc-fovea distance on macular thickness measurements with OCT in healthy myopic eyes

Qiu, Kunliang; Wang, Geng; Zhang, Riping; Lu, Xuehui; Zhang, Mingzhi; Jansonius, Nomdo M.

doi:10.1038/s41598-018-23479-z

Cited by 10 publications

(12 citation statements)

References 42 publications

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“…This is unlikely to affect the study results, considering the low prevalence of normal‐tension glaucoma. In addition, we did not adjust retinal measurements by eye axial length nor fovea‐to‐disc distance, which influence pRNFL and macular layers thicknesses 32,33 …”

Section: Discussionmentioning

confidence: 99%

Characterization of Retinal Architecture in Spinocerebellar Ataxia Type 3 and Correlation with Disease Severity

et al. 2021

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Background Neurodegeneration affects the brain and peripheral nervous system in spinocerebellar ataxia type 3 (SCA3). As the retina is also involved, studying the retinal architecture in a cohort of patients could reveal clinically relevant biomarkers. Objective The aim is to investigate retinal architecture in SCA3 to identify potential biomarkers. Methods We evaluated 38 patients with SCA3 and 25 healthy age‐matched controls, who underwent visual acuity assessment, intraocular pressure measurement, and fundoscopy and macular and peripapillary spectral domain optical coherence tomography (SD‐OCT). We measured the peripapillary retinal nerve fiber layer (pRNFL) thickness in each quadrant of the temporal‐superior‐nasal‐inferior‐temporal chart and the macular layer thicknesses in each sector of the inner circle of the Early Treatment Diabetic Retinopathy Study (IC‐ETDRS) grid. Linear regression analysis was employed to test the associations between retinal parameters and age, disease duration, CAG repeats, and SARA (Scale of the Assessment and Rating of Ataxia) and ICARS (International Cooperative Ataxia Rating Scale) scores in SCA3. Results In all sectors, except for the temporal quadrant, pRNFL was significantly thinner in SCA3 patients than in controls. Average total macular, ganglion cell layer (GCL), and inner plexiform layer (IPL) thicknesses were significantly decreased in SCA3 patients in comparison to controls. The average total macular thickness and the average thicknesses of RNFL, GCL, and IPL negatively correlated with ICARS scores, whereas average GCL and IPL thicknesses negatively correlated with SARA scores. Conclusions The retinal ganglion cells, their dendrites, and axons are selectively affected in SCA3 patients. The RNFL, GCL, and IPL thicknesses in SD‐OCT correlate with the clinical phenotype and represent potential biomarkers for future clinical trials and natural history studies. © 2021 International Parkinson and Movement Disorder Society

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Section: Discussionmentioning

confidence: 99%

Characterization of Retinal Architecture in Spinocerebellar Ataxia Type 3 and Correlation with Disease Severity

et al. 2021

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“…Associations between ocular and systemic factors with intra-retinal layers were assessed using age-gender-ethnicity-model and multivariate linear regression models with generalized estimating equations to account for the correlation between pairs of eyes for each individual. Covariates such as hyperlipidemia, hypertension, corneal curvature, axial length, refractive error, optic disc area were considered because they were related to macular thickness 17,19,37,61 . These covariates were adjusted in the multivariate model if they had a statistical significance of P < 0.05 in the first model.…”

Section: Methodsmentioning

confidence: 99%

Age-related changes of individual macular retinal layers among Asians

Chua

Tham

Tan

et al. 2019

Sci Rep

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We characterized the age-related changes of the intra-retinal layers measured with spectral-domain optical coherence tomography (SD-OCT; Cirrus high-definition OCT [Carl Zeiss Meditec]. The Singapore Epidemiology of Eye Diseases is a population-based, cross-sectional study of Chinese, Malays and Indians living in Singapore. Iowa Reference Algorithms (Iowa Institute for Biomedical Imaging) were used for intra-retinal layer segmentation and mean thickness of 10 intra-retinal layers rescaled with magnification correction using axial length value. Linear regression models were performed to investigate the association of retinal layers with risk factors. After excluding participants with history of diabetes or ocular diseases, high-quality macular SD-OCT images were available for 2,047 participants (44–89 years old). Most of the retinal layers decreased with age except for foveal retinal nerve fiber layer (RNFL) and the inner/outer segments of photoreceptors where they increased with age. Men generally had thicker retinal layers than women. Chinese have the thickest RNFL and retinal pigment epithelium amongst the ethnic groups. Axial length and refractive error remained correlated with retinal layers in spite of magnification correction. Our data show pronounced age-related changes in retinal morphology. Age, gender, ethnicity and axial length need be considered when establishing OCT imaging biomarkers for ocular or systemic disease.

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“…62 Recently, another independent determinant of macular layer thickness was reported: disk fovea distance. 63,64 We investigated the effect of this variable on GCIPL thickness, but we did not find a significant association utilizing whole field and sector-wise analyses (data not shown in Results). This may be due to differences in the populations analyzed; the previous studies either analyzed total retinal thickness (GCIPL in this study) 64 or excluded myopic eyes with spherical equivalent less than -6.0 diopters.…”

Section: Discussionmentioning

confidence: 93%

Relationship Between Macular Ganglion Cell Thickness and Ocular Elongation as Measured by Axial Length and Retinal Artery Position

Fujishiro

Murata

Fujino

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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Purpose We recently reported on the usefulness of retinal artery trajectory in estimating the magnitude of retinal stretch due to myopia. The purpose of the present study was to elucidate the relationship between the peripapillary retinal artery angle (PRAA) and thickness of the macular ganglion cell–inner plexiform layer (GCIPL). Methods This r included 138 healthy eyes of 79 subjects older than 20 years of age without any known eye disease. GCIPL thickness was separated into eight sectors according to quadrant and eccentricity from the fovea. The PRAA was calculated as the angle between the superior and inferior retinal arteries. Relationships between whole GCIPL thickness (average and sectorial) and the values of PRAA and axial length (AL) were investigated using a linear mixed model. Results Average GCIPL thickness in the whole scanned area decreased significantly with narrowing of the PRAA with and without adjusting for AL. Sectorized macular GCIPL thickness also decreased significantly, with narrowing of the PRAA in seven out of the eight with the adjustment of AL, the exception being the inferior peripheral temporal sector. Conclusions Macular GCIPL thickness decreased significantly with narrowing of the PRAA on average and in seven out of eight sectors.

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Influence of optic disc-fovea distance on macular thickness measurements with OCT in healthy myopic eyes

Cited by 10 publications

References 42 publications

Characterization of Retinal Architecture in Spinocerebellar Ataxia Type 3 and Correlation with Disease Severity

Characterization of Retinal Architecture in Spinocerebellar Ataxia Type 3 and Correlation with Disease Severity

Age-related changes of individual macular retinal layers among Asians

Relationship Between Macular Ganglion Cell Thickness and Ocular Elongation as Measured by Axial Length and Retinal Artery Position

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