KEYWORDS dental pain; pericoronitis; quality of life; symptomatic irreversible pulpitis; VAS Abstract Background/purpose: The oral health-related quality of life (OHRQoL) reveals important information about a patient's perceptions in clinical practice, and pain is a critical point when evaluating OHRQoL in clinical practice. The aim of the study was to compare pain patterns by means of the Dental Pain-Screening Questionnaire (DePaQ) and an OHRQoL evaluation between symptomatic irreversible pulpitis and pericoronitis. Materials and methods: In this cross-sectional study, 50 patients with symptomatic irreversible pulpitis (with a female:male ratio of 22:28 and a mean age of 35.6 AE 11.8 years) and 38 patients with pericoronitis (with a female:male ratio of 21:17 and a mean age of 26.3 AE 9.08 years) were selected. In addition to a visual analogue scale (VAS, 0e100 mm), dental pain was evaluated by means of a Dental Pain Questionnaire (DePaQ). The Oral Health Impact Profile-14 (OHIP-14) was used to examine the OHRQoL status. Results: Scores of the OHIP-14 and VAS were significantly higher in patients with irreversible pulpitis (29.9 AE 11.8 and 91.80 AE 10.03, respectively) compared to those suffering from pericoronitis (18.6 AE 8.7 and 51.05 AE 36.67, respectively; P < 0.001). According to the DePaQ, the presence of continuous pain, pain radiating to the surrounding area, pain when chewing or eating on the side of the mouth with the affected teeth, pain experienced as an electric shock, and difficulty sleeping were related to a poor OHIP-14 score in symptomatic irreversible pulpitis (33.5 AE 10.57, 30.82 AE 11.4, 30.30 AE 11.55, 33.92 AE 10.28,and 27.53 AE 11.77, respectively) compared with those with pericoronitis (20. 09 AE 11.27, 20.37 AE 7.85, 19.64 AE 7.87, 20.56 AE 9.69,and 19.88 AE 7.9, respectively; P Z 0.003, <0.001, <0.001, <0.001, and 0.005, respectively). VAS scores significantly differed between groups according to all DePaQ items (P < 0.05).