Influence of Orally Administered Probiotic Lactobacillus Strains on Vaginal Microbiota in Women with Breast Cancer during Chemotherapy: A Randomized Placebo-Controlled Double-Blinded Pilot Study

Marschalek, Julian; Farr, Alex; Marschalek, Marie-Louise; Domig, Konrad J.; Kneifel, Wolfgang; Singer, Christian F.; Kiss, Herbert; Petricevic, Ljubomir

doi:10.1159/000478994

Cited by 34 publications

(19 citation statements)

References 26 publications

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“…In addition to cervical cancer, Lactobacillus is associated with the proliferation and regulation of cells of other cancer types, such as breast cancer, 32 colorectal cancer, 33 gastric cancer, 34 and oral cancer. 35 , 36 Observations in these other cancers may offer insights into the study of Lactobacillus in cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

Role of <em>Lactobacillus</em> in cervical cancer

Yang¹,

Da²,

Zhang³

et al. 2018

CMAR

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Cervical cancer is a common malignant cancer among women worldwide. Changes in the vaginal microecological environment lead to multiple gynecological diseases, including cervical cancer. Recent research has shown that Lactobacillus may play an important role in the occurrence and development of cervical cancer. This review explores the role of Lactobacillus in cervical cancer. A total of 29 articles were included after identification and screening. The pertinent literature on Lactobacillus in cervical cancer from two perspectives, including clinical studies and experimental studies, was analyzed. An association network for the mechanism by which Lactobacillus induces cervical cancer was constructed. In addition, we provide direction and insight for further research on the role of Lactobacillus in cervical cancer.

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Section: Discussionmentioning

confidence: 99%

Role of <em>Lactobacillus</em> in cervical cancer

Yang¹,

Da²,

Zhang³

et al. 2018

CMAR

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“…2C ). A number of recent studies have emphasized the role of Lactobacillus species in treating and preventing breast cancer growth and metastasis [ 36 , 37 ]. The possible mechanisms of Lactobacillus induced protection include immune activation, competitive inhibition of pathogenic strains and synthesis of signaling intermediates.…”

Section: The Microbiome and Its Association With Breast Cancermentioning

confidence: 99%

The power of small changes: Comprehensive analyses of microbial dysbiosis in breast cancer

Parida

Sharma

2019

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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Disparate occurrence of breast cancer remains an intriguing question since only a subset of women with known risk factors develop cancer. Recent studies suggest an active role of local and distant microbiota in breast cancer initiation, progression, and overall prognosis. A dysbiotic microbiota predisposes the body to develop cancer by inducing genetic instability, initiating DNA damage and proliferation of the damaged progeny, eliciting favorable immune response, metabolic dysregulation and altered response to therapy. In this review, we present our analyses of the existing datasets and discuss the local dysbiosis observed in breast cancer patients and different aspects of breast carcinogenesis that can be potentially influenced by local breast microbiota. Striking differences between microbial community compositions in breast of cancer patients compared to healthy individuals were noted. Differences in microbiome were also apparent between benign and malignant disease and between nipple aspirate fluid of healthy individuals and breast survivors. We also discuss the identification of distinct bacterial, fungal, viral as well as parasite signatures for breast cancer. These microbes are capable of producing numerous secondary metabolites that can act as signaling mediators effecting breast cancer progression. We review how microbes potentially alter response to therapy affecting drug metabolism, pharmacokinetics, anti-tumor effects and toxicity. In conclusion, breast harbors a community of microbes that can communicate with the host cells inducing downstream signaling pathways and modulating various aspects of breast cancer growth and metastatic progression and an improved understanding of microbial dysbiosis can potentially reduce breast cancer risk and improve outcomes of breast cancer patients. The human microbiome, now referred to as, the “forgotten organ” contains a metagenome that is 100-fold more diverse compared to the human genome, thereby, is critically associated with human health [ 1 , 2 ]. With the revelations of the human microbiome project and advent of deep sequencing techniques, a plethora of information has been acquired in recent years. Body sites like stomach, bladder and lungs, once thought to be sterile, are now known to harbor millions of indigenous microbial species. Approximately 80% of the healthy microbiome consists of Firmicutes and Bacteroidetes accompanied by Verrucomicrobia , Actinobacteria , Proteobacteria , Tenericutes and Cyanobacteria [ 2 – 7 ]. The role of microbiome in diabetes, obesity and even neurodegenerative diseases was greatly appreciated in the last decade [ 1 , 7 – 14 ] and now it has been established that microbiome significantly contr...

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“…Probiotic bacteria have been proposed to influence systems beyond the gastrointestinal (GI) tract and confer several benefits to the host [16][17][18]. In the present study, we demonstrate for the first time that the probiotic strain Lactobacillus plantarum 286, but not the strain Lactobacillus plantarum 81, exerted anti-depressant-and anxiolytic-like effects in male mice without altering general locomotor activity or memory consolidation/retrieval.…”

Section: Discussionmentioning

confidence: 56%

Effects of chronic treatment with new strains of Lactobacillus plantarum on cognitive, anxiety- and depressive-like behaviors in male mice

et al. 2020

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Psychobiotics correspond to a class of probiotics, mainly of the genus Lactobacillus and Bifidobacterium, capable of producing neuroactive substances, such as γ-aminobutyric acid (GABA) and serotonin, which exert effects on the brain-gut axis. Evidence suggests that psychobiotics can have a beneficial effect on mood, anxiety and cognition. The present study evaluated the effects of chronic administration of two new strains of Lactobacillus plantarum, L. plantarum 286 (Lp 286) and L. plantarum 81 (Lp 81) isolated from the fermentation of cocoa (Theobroma cacao L.) and cupuaçu (Theobroma grandiflorum), respectively, on cognitive, anxiety-and depressive-like behaviors in male Swiss mice. Different groups of animals were administered (oral gavage) solutions of vehicle (0.85% saline plus 15% skim milk), Lp 286 (10 9 /0.1 ml CFU) or Lp 81 (10 9 /0.1 ml CFU) for 30 days, and animals were tested for general locomotor activity, depressive-like behavior in the forced swim test, and learning/memory and anxiety-like behavior in the plus-maze discriminative avoidance task. Treatment with the strains Lp 286 and Lp 81 did not interfere with locomotor activity or learning and memory. The Lp 286 strain exerted anti-depressant-and anxiolytic-like effects under our experimental conditions. Our findings add to the current body of evidence suggesting that probiotics from the genus Lactobacillus may exert psychobiotic potential and introduce a new strain, Lp 286, as a potential candidate in the prevention or as therapeutic adjuvant in the treatment of mental disorders.

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Influence of Orally Administered Probiotic Lactobacillus Strains on Vaginal Microbiota in Women with Breast Cancer during Chemotherapy: A Randomized Placebo-Controlled Double-Blinded Pilot Study

Cited by 34 publications

References 26 publications

Role of <em>Lactobacillus</em> in cervical cancer

Role of <em>Lactobacillus</em> in cervical cancer

The power of small changes: Comprehensive analyses of microbial dysbiosis in breast cancer

Effects of chronic treatment with new strains of Lactobacillus plantarum on cognitive, anxiety- and depressive-like behaviors in male mice

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