Influence of ovarian stage on transcript profiles in fathead minnow (Pimephales promelas) ovary tissue

Villeneuve, Daniel L.; García-Reyero, Natàlia; Martinović, Dalma; Cavallin, Jenna E.; Mueller, Nathaniel D.; Wehmas, Leah C.; Kahl, Michael D.; Linnum, Anne L.; Perkins, Edward J.; Ankley, Gerald T.

doi:10.1016/j.aquatox.2010.03.006

Cited by 40 publications

(24 citation statements)

References 53 publications

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“…Yet, there was a trend in cyp19a1a transcription in females, which increased toward vitellogenesis and decreased after spawning coinciding with previous observations in which up-regulation of cyp19a1a is required to trigger and go through ovarian differentiation in female fish (Guiguen et al, 2010). Even if not significant differences among gametogenic stages were detected in ovarian cyp19a1a transcription levels in mullets, observed trends in females were sufficient to promote P450arom activity and regulate E2 levels in the plasma, as described for several fish species (Chourasia and Joy, 2008;Ings and Van der Kraak, 2006;Nakamura et al, 2005;Villeneuve et al, 2010). Moderate changes in the transcription of steroidogenic genes, such as cyp11b1 and cyp19a1a, in the gonads of rainbow trout also lead to significant changes in aromatase activity and steroid plasma levels during gametogenesis of rainbow trout (Kusakabe et al, 2006).…”

Section: Discussionsupporting

confidence: 82%

Steroidogenesis and phase II conjugation during the gametogenesis of thicklip grey mullet (Chelon labrosus) from a population showing intersex condition

Sardi

Bizarro

Cajaraville

et al. 2015

General and Comparative Endocrinology

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Section: Discussionsupporting

confidence: 82%

Steroidogenesis and phase II conjugation during the gametogenesis of thicklip grey mullet (Chelon labrosus) from a population showing intersex condition

Sardi

Bizarro

Cajaraville

et al. 2015

General and Comparative Endocrinology

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“…Similarly, transgelin is an early marker of smooth muscle differentiation, but its exact functions are unknown [3]. Transgelin has previously been detected in the fathead minnow ovary, where it was highly upregulated in vitellogenic and mature follicles [70]. These results suggest that smooth muscle genes are upregulated in the late vitellogenic follicle wall and may function in ovulatory competency for follicular rupture during ovulation.…”

Section: Smooth Muscle Gene Upregulationmentioning

confidence: 82%

Identification of ovarian gene expression patterns during vitellogenesis in Atlantic cod (Gadus morhua)

Breton

Anderson

Goetz

et al. 2012

General and Comparative Endocrinology

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Follicular maturational competence and ovulatory competence in teleost fish refer to the ability of the ovarian follicle to undergo final oocyte maturation and ovulation, respectively, in response to gonadotropin stimulation and other external cues. Some gene products related to competence acquisition are likely synthesized during vitellogenic growth, as these follicles gain in vivo responsiveness to exogenous gonadotropin stimulation and can be induced to undergo maturation and ovulation. In Atlantic cod (Gadus morhua), gonadotropin responsiveness has been shown to be oocyte size-dependent, and only ovaries containing late-stage vitellogenic follicles can be induced to ovulate. The purpose of the present study was to compare gene expression patterns between mid (unresponsive) and late (responsive) vitellogenic ovaries to identify genes involved in gonadotropin responsiveness and the acquisition of maturational and ovulatory competencies. Representational difference analysis was conducted in two reciprocal comparisons using intact ovarian fragments and follicle wall-enriched tissues, and genes of interest were used in real time quantitative PCR to confirm differential expression. Few differences were detected in intact ovarian fragments, but type IV ice-structuring protein and gephyrin were upregulated later in development and may be involved in lipid and sulfur metabolism, respectively. Candidate gene assays for luteinizing hormone receptor and aromatase also exhibited significant upregulation during vitellogenesis. Many genes were differentially expressed in follicle wall-enriched tissues, including endocrine maturational regulators and smooth muscle genes. Overall, maturational and ovulatory competencies during vitellogenesis in Atlantic cod are associated with up- and downregulation of many genes involved in lipid metabolism, endocrine regulation, and ovulatory preparation.

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“…Of them, the gene for HtrA3, a family member of serine proteases which is involved in ovarian functions has been shown to be amplified in ovarian cancer (6).…”

Section: Discussionmentioning

confidence: 99%

“…The high temperature requirement factor A3 (HtrA3) belongs to the HtrA family of ATP-independent serine proteases, which are involved in important physiological processes including maintenance of mitochondrial homeostasis, cell death (apoptosis, necrosis, and anoikis) and cell signaling (4). HtrA3 has been shown to be involved in ovarian development (5,6). Although the role of HtrA3 in ovarian development is less clear, a study demonstrated that expression of HtrA3 is up-regulated during folliculogenesis and luteinization in the rhesus monkey ovary (7).…”

Section: Introductionmentioning

confidence: 98%

HTRA3 is Reduced in Ovarian Cancers Regardless of Stage

Zhao

Ding

Nie³

et al. 2014

Cancer Investigation

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Ovarian cancer is the leading cause of death in gynaecological cancers. The high temperature requirement factor A3 (HtrA3) is involved in the pathogenesis of ovarian cancer. In this study we investigated whetherHtrA3 protein levels were altered in subtypes of ovarian cancer and whether HtrA3 down-regulation was associated with peritoneal metastasis. Ovarian cancer tissues from 89 patients were analyzed by immunohistochemistry. The levels of HtrA3 protein were lower in all subtypes of ovarian cancer and the lowest levels of HtrA3 were in epithelial ovarian cancer. The down-regulation of HtrA3 levels was not correlated with peritoneal metastasis of epithelial ovarian cancer.

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Influence of ovarian stage on transcript profiles in fathead minnow (Pimephales promelas) ovary tissue

Cited by 40 publications

References 53 publications

Steroidogenesis and phase II conjugation during the gametogenesis of thicklip grey mullet (Chelon labrosus) from a population showing intersex condition

Steroidogenesis and phase II conjugation during the gametogenesis of thicklip grey mullet (Chelon labrosus) from a population showing intersex condition

Identification of ovarian gene expression patterns during vitellogenesis in Atlantic cod (Gadus morhua)

HTRA3 is Reduced in Ovarian Cancers Regardless of Stage

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