Influence of ovarian stimulation with HMG or recombinant FSH on OHSS prevention in PCO patients undergoing IVF

Türkçapar, Figen; Özdener, T.; Batuoglu, S.

doi:10.1016/j.fertnstert.2009.07.1042

Cited by 3 publications

(1 citation statement)

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“…Recombinant follicle-stimulating hormone (rFSH) follows a long down-regulation protocol in IVF intracytoplasmic sperm injection (ICSI) treatment cycles [ 9 ]. After oocytes are collected, meiosis begins again by administering a human chorionic gonadotrophin (hCG) trigger, known as hCG priming.…”

Section: Introductionmentioning

confidence: 99%

Overcoming PCOS-Related Infertility by Using In Vitro Maturation Approach: A Case Report

Jain,

Bawaskar,

Nair

et al. 2024

Cureus

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Polycystic ovary syndrome (PCOS) is an endocrinological disorder affecting women of reproductive age, characterized by hormonal imbalance leading to metabolic and reproductive dysregulations. This case report revolves around a 30-year-old husband and his 27-year-old partner. The male partner had normozoospermia, and the female spouse had PCOS, according to the couple's diagnostic evaluations. The female patient received ovarian stimulation specifically to assist with PCOS, and the retrieved oocytes were then matured in vitro. After intracytoplasmic sperm injection (ICSI), fertilization and embryonic development were successful. Treatment of PCOS-related infertility presents many challenges, and in vitro maturation (IVM) and its potential as an effective assisted fertility method are discussed. To optimize treatment outcomes, the conclusion shows the importance of IVM and other assisted reproductive techniques for infertility. It also focuses on the necessary continuous research and clinical experience. Clinical pregnancy was confirmed by measuring serum beta-human chorionic gonadotropin (β-hCG) levels followed by ultrasound sonography (USG), which showed a normal growth rate of the fetus.

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Section: Introductionmentioning

confidence: 99%

Overcoming PCOS-Related Infertility by Using In Vitro Maturation Approach: A Case Report

Jain,

Bawaskar,

Nair

et al. 2024

Cureus

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LH-containing gonadotropin preparations in IVF programs (literature review)

Krasnopolskaya¹,

Sokolova²,

Beketova³

2019

Probl. reprod.

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Analysis of the clinical efficiency of human menopausal gonadotropins in the assisted reproductive technology program

2021

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Introduction. Comparative analysis of urinary and recombinant gonadotropins is ongoing to improve the efficiency of assisted reproductive technology programs. Particular interest focused on the identification of individual groups of patients with maximal efficacy of using certain ovarian stimulation drugs in an assisted reproductive technology program.Objective. To review the application of Menopur Multidose 1200 IU for ovarian stimulation in assisted reproductive technology protocols with gonadotropin-releasing hormone agonists (GnRH) or gonadotropin-releasing hormone antagonists (GnRH antagonists) in the current clinical practice.Materials and methods. The study retrospectively enrolled 4,080 women aged 20-43 years. Ovarian stimulation in the Assisted Reproductive Technology program was performed using the GnRH antagonist protocol in 65.8% of patients and the GnRH agonist protocol with Menopur Multidose 1200 IU with or without the additional Menopur 75 IU in 34.2% of women.Results. Clinical and laboratory data of the patients, stimulated cycle parameters, characteristics of the embryological stage, and results of the assisted reproductive technology program were analyzed. The frequency of obtaining degenerated oocytes did not exceed 5%. The relative number of blastocysts of good quality was 59.9%, while for patients in the older age group, the figure was 54.6. The average pregnancy rate in patients in the “Menopur Multidose 1200 IU p/k” group was 39.3%, which corresponds to high-performance indicators of the assisted reproductive technology program.Conclusions. Administration of highly purified human menopausal gonadotropin (hMG) (Menopur Multidose 1200 IU) to stimulate ovarian function in patients of different ages is accompanied by an adequate number of mature oocytes, good quality blastocysts, and satisfactory clinical pregnancy rates. Thus, highly purified human menopausal gonadotropin is not inferior to recombinant follicle-stimulating hormone(r-FSH) concerning the efficacy of assisted reproductive technology programs.

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Influence of ovarian stimulation with HMG or recombinant FSH on OHSS prevention in PCO patients undergoing IVF

Cited by 3 publications

References 0 publications

Overcoming PCOS-Related Infertility by Using In Vitro Maturation Approach: A Case Report

Overcoming PCOS-Related Infertility by Using In Vitro Maturation Approach: A Case Report

LH-containing gonadotropin preparations in IVF programs (literature review)

Analysis of the clinical efficiency of human menopausal gonadotropins in the assisted reproductive technology program

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