Influence of ovine growth hormone on water and NaCl absorption by the rat proximal jejunum and distal ileum

Mainoya, J. R.

doi:10.1016/0300-9629(82)90439-x

Cited by 29 publications

(15 citation statements)

References 13 publications

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“…The first observation confirms and extends the previously reported proabsorptive effect of animal GH (8,19) to recombinant DNA-derived human GH. Furthermore, this work first shows that the effect on intestinal transport has a rapid onset, being observed within minutes from a single i.v.…”

Section: """"------------------------- --------supporting

confidence: 87%

“…4x1O-6 6x10 -6 8x10-6 r-hGH con centration (M) 5x1O-7 10 -7 It has been previously reported that hypophysectomy causes a decrease in water and electrolyte absorption in the rat jejunum and this can be prevented by pretreatment with bovine GH (19) . An intestinal proabsorptive effect has been previously reported in normal rats, receiving ovine GH by s.c. route (8) .…”

Section: Lack Ofreversibility Ofr-hgh Effectmentioning

confidence: 99%

“…Furthermore, GH increases the gastrin and somatostatin contents of rat stom ach , (7). Finally, it has been previousl y shown that high doses of ovine GH, given to rats for 2 d in vivo, incre ased the absorption rates of H 2 0 and electrolytes as measured by intestinal everted sacs (8). The effects of GH have been tradi-chloride, indicating that it was related, at least in part, to inhibition of basal active chloride secretion.…”

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confidence: 91%

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In Vivo and In Vitro Effects of Human Growth Hormone on Rat Intestinal Ion Transport

et al. 1995

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It has been reported that: I ) ovine growth hormone stimulates intestinal water, sodium, and chloride absorption and 2) specific growth hormone receptors are present in the rat intestine. Aims of this work were to investigate the effects of acute administration of hGH on water and ion transport in the rat ileum in vivo and in vitro. In vivo, the absorption rates of water, sodium, chloride, and potassium were determined in the rat perfused ileum, during a basal period and after i.v. administration of 6 Mg/kg recombinant DNA-derived hGH. In vitro , electrical parameters were measured before and after the hormone addition to the mucosal or the serosal side of rat ileal mucosa mounted in Ussing chambers. In vivo, growth hormone induced a rapid increase in the absorption rates of water, sodium, chloride, and potassium. In vitro, the serosal, but not the mucosal, addition of growth hormone induced a rapid decrease of transepithelial potential difference and of short-circuit current. The effect was time-and dose-dependent, saturable, but not reversible in the short time. The electrical'effect was abolished in the absence of The ability of GH to induce fluid retenti on is well established , but the mechanisms of this effect are not well und erstood (1). Most studies have focused on the interr elationships between various hormones taking part to the complex network that regulates Na + balance and on the renal effects of GH (1).It is now known that the intestine plays an important role in the regulation of body fluid home ostasis (2). GH has several effects at the intestinal level. In fact, it stimulates intestinal growth and differentiation (3, 4), vitamin D-dep endent Ca 2 + binding protein synthesis (5), and Ca 2 + absorption (6). Furthermore, GH increases the gastrin and somatostatin contents of rat stom ach ,(7). Finally, it has been previousl y shown that high doses of ovine GH, given to rats for 2 d in vivo, incre ased the absorption rates of H 2 0 and electrolytes as measured by intestinal everted sacs (8). chloride, indicating that it was related, at least in part, to inhibition of basal active chloride secretion. Growth hormone also reduced the short-circuit current increase induced by the secretagogues Escher ichia coli heat-stable enterotoxin, theophylline, and calcium ionophore A23187. These results indicate that hGH has a rapid absorptive effect that is related, at least in part, to a direct intestinal antisecretory mechanism. It also reduces active intestinal secretion induced by various secretagogues. (Pediatr Res 37: 576-580, 1995) Abbreviations GH , growth hormone r·hGH, recombinant DNA-derived hGH Isc, short-circuit current PD, transepithelial potential difference G, tissue conductance ST, Escherichia coli heat-stable enterotoxin tionally believed to be mediat ed by GH-dep endent production of mediators such as IGF-I (9, 10). Howe ver, it has been report ed that IGF-I does not cause fluid retention (11). Recently GH has been shown to inhibit the production of the atrial natriuretic peptid e (12) . I...

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confidence: 87%

Section: Lack Ofreversibility Ofr-hgh Effectmentioning

confidence: 99%

mentioning

confidence: 91%

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In Vivo and In Vitro Effects of Human Growth Hormone on Rat Intestinal Ion Transport

et al. 1995

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“…Extensive studies in various experimental models of SBS have established that exogenous administration of growth hormone enhances mucosal hyperplasia and increases water, electrolyte and nutrient absorption [24,25]. In a rabbit model of SBS, Avissar et al [26] recently demonstrated that treatment with growth hormone for 2 weeks restored a Na(+)-dependent broad-spectrum neutral amino acid transporter (ATB(0)/ASCT2) protein in the jejunum and ileum, which is responsible for downregulated glutamine transport in rabbit residual bowel following 70% small bowel resection [26].…”

Section: Intestinal Adaptation and Hormonesmentioning

confidence: 99%

Advances in short bowel syndrome: an updated review

et al. 2005

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Short bowel syndrome (SBS) continues to be an important clinical problem due to its high mortality and morbidity as well as its devastating socioeconomic effects. The past 3 years have witnessed many advances in the investigation of this condition, with the aim of elucidating the cellular and molecular mechanisms of intestinal adaptation. Such information may provide opportunities to exploit various factors that act as growth agents for the remaining bowel mucosa and may suggest new therapeutic strategies to maintain gut integrity, eliminate dependence on total parenteral nutrition, and avoid the need for intestinal transplantation. This review summarizes current research on SBS over the last few years.

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“…They reported that administration of hGH to burn patients resulted in an improvement of nitrogen and potassium balance and enhanced wound healing. Based on initial observations showing GH can increase nutrient and electrolyte absorption in hypophysectemized animals [82], Byrne et al [83] reported in a nonrandomized, open study that GH and dietary modification improved nutrient absorption in patients with small bowel syndrome. Subse-quent studies using more rigorous techniques have shown no effect on nutrient absorption with GH treatment in human patients [84,85], whereas a variety of animal studies have shown conflicting results [86][87][88].…”

Section: Human Growth Hormone (Hgh)mentioning

confidence: 99%

Factors Enhancing Intestinal Adaptation after Bowel Compensation

Botsios

Vasiliadis²

2003

Dig Dis

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Intestinal failure (IF) refers to the condition in which certain causes lead to derangements in nutrient absorption capacity. Gut adaptation occurs in response to IF and it is both morphologic and physiologic in nature and can be mediated by growth factors and nutrients. Our paper reviews certain trophic growth factors that have important interactions relevant for intestinal growth, function and adaptation. Data Source: The literature was reviewed (data from both animal and human studies) and certain trophic factors that modulate intestinal adaptation are summarized. The factors reviewed are: epidermal growth factor, insulin-like growth factor I and II, transforming growth factor α and β, neurotensin, interleukin-11, glucagon-like peptide-2, keratinocyte growth factor, human growth hormone, short-chain fatty acids, and glutamine. Conclusions: Growth factors augment intestinal proliferation, diminish programmed apoptosis, and modulate the adaptive process. They also have the potential to improve nutrient absorption in some bowel disease. The enhancement of gut adaptation may allow patients to transition of parenteral/enteral to normal nutrition, in a shorter period of time, which reduce the rate of adverse effects caused by artificial nutrition and improve quality of life.

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Influence of ovine growth hormone on water and NaCl absorption by the rat proximal jejunum and distal ileum

Cited by 29 publications

References 13 publications

In Vivo and In Vitro Effects of Human Growth Hormone on Rat Intestinal Ion Transport

In Vivo and In Vitro Effects of Human Growth Hormone on Rat Intestinal Ion Transport

Advances in short bowel syndrome: an updated review

Factors Enhancing Intestinal Adaptation after Bowel Compensation

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