Influence of oxidative stress on the level of genes expression TGFB1 and HGF in rat liver upon long-term gastric hypochlorhydria and administration of multiprobiotic Symbiter

Dvorshchenko, K.

doi:10.15407/ubj85.05.114

Cited by 13 publications

(4 citation statements)

References 51 publications

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“…A previous study has suggested that TGFB is a crucial regulator of central nervous system development (Gomes et al, 2005). It has been found that the level of TGFB1 affected oxidative stress in rat liver (Dvorshchenko et al, 2013). After PAMAM dendrimer exposure, the expression of TGFB1 was greatly inhibited, inferring that dendrimer treatment may affect oxidative stress in cells and human central nervous system development.…”

Section: A B C Dmentioning

confidence: 97%

Effects of PAMAM dendrimers with various surface functional groups and multiple generations on cytotoxicity and neuronal differentiation using human neural progenitor cells

et al. 2016

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-Polyamidoamine (PAMAM) dendrimers have potential for biological applications as delivery systems for genes, drugs, and imaging agents into the brain, but their developmental neurotoxicity remains unknown. We investigated the effects of PAMAM dendrimers with various surface functional groups and multiple generations on neuronal differentiation using human neural progenitor cells at an equal mass concentration. Only PAMAM dendrimers containing amine (NH 2 ) surface groups at concentrations of 10 μg/mL significantly reduced cell viability and neuronal differentiation, compared with non-amine-terminated dendrimers. PAMAM-NH 2 with generation (G)3, G4, G5 G6, and G7 significantly decreased cell viability and inhibited neuronal differentiation from a concentration of 5 μg/mL, but G0, G1, and G2 dendrimers did not have any effect at this concentration. Cytotoxicity indices of PAMAM-NH 2 dendrimers at 10 μg/mL correlated well with the zeta potentials of the particles. Surface group density and particle number in unit volume is more important characteristic than particle size to influence cytotoxicity for positive changed dendrimers. PAMAM-50% C 12 at 1 μg/mL altered the expression level of the oxidative stress-related genes, ROR1, CYP26A1, and TGFB1, which is a DNA damage response gene. Our results indicate that PAMAM dendrimer exposure may have a surface charge-dependent adverse effect on neuronal differentiation, and that the effect may be associated with oxidative stress and DNA damage during development of neural cells.

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Section: A B C Dmentioning

confidence: 97%

Effects of PAMAM dendrimers with various surface functional groups and multiple generations on cytotoxicity and neuronal differentiation using human neural progenitor cells

et al. 2016

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“…Hypochlorhydria may, in fact, be more common in the aging population as the gut physiology changes [64], and the use of certain medications can also impact hydrochloric acid levels [65]. Further, oxidative stress (such as seen with low physiological glutathione levels) [66,67] and certain nutrient deficiencies [68] may also contribute to low stomach acid levels.…”

Section: Dietary Protein Considerationsmentioning

confidence: 99%

A Review of Dietary (Phyto)Nutrients for Glutathione Support

Minich

Brown²

2019

Nutrients

157

118

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Glutathione is a tripeptide that plays a pivotal role in critical physiological processes resulting in effects relevant to diverse disease pathophysiology such as maintenance of redox balance, reduction of oxidative stress, enhancement of metabolic detoxification, and regulation of immune system function. The diverse roles of glutathione in physiology are relevant to a considerable body of evidence suggesting that glutathione status may be an important biomarker and treatment target in various chronic, age-related diseases. Yet, proper personalized balance in the individual is key as well as a better understanding of antioxidants and redox balance. Optimizing glutathione levels has been proposed as a strategy for health promotion and disease prevention, although clear, causal relationships between glutathione status and disease risk or treatment remain to be clarified. Nonetheless, human clinical research suggests that nutritional interventions, including amino acids, vitamins, minerals, phytochemicals, and foods can have important effects on circulating glutathione which may translate to clinical benefit. Importantly, genetic variation is a modifier of glutathione status and influences response to nutritional factors that impact glutathione levels. This narrative review explores clinical evidence for nutritional strategies that could be used to improve glutathione status.

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“…Окисний стрес, що при цьому виникає, су-проводжується порушенням молекулярних механізмів регуляторних процесів у клітині й призводить до зміни експресії окремих генів [1,3].…”

Section: вступunclassified

Expression of Reg1α, Gast and Tgfb1 Genes in Conditions of Stressinduced Gastric Mucous Lesions Development and Healing in Rats

Dranitsina¹,

Morgaienko²,

Grebinyk³

et al. 2015

Fiziol Zh

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Influence of oxidative stress on the level of genes expression TGFB1 and HGF in rat liver upon long-term gastric hypochlorhydria and administration of multiprobiotic Symbiter

Cited by 13 publications

References 51 publications

Effects of PAMAM dendrimers with various surface functional groups and multiple generations on cytotoxicity and neuronal differentiation using human neural progenitor cells

Effects of PAMAM dendrimers with various surface functional groups and multiple generations on cytotoxicity and neuronal differentiation using human neural progenitor cells

A Review of Dietary (Phyto)Nutrients for Glutathione Support

Expression of Reg1α, Gast and Tgfb1 Genes in Conditions of Stressinduced Gastric Mucous Lesions Development and Healing in Rats

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