Influence of oxidized lipids on palmitoyl-oleoyl-phosphatidylcholine organization, contribution of Langmuir monolayers and Langmuir–Blodgett films

Grauby–Heywang, Christine; Moroté, Fabien; Mathelié‐Guinlet, Marion; Gammoudi, Ibtissem; Faye, Ndeye Rokhaya; Cohen–Bouhacina, Touria

doi:10.1016/j.chemphyslip.2016.07.001

Cited by 14 publications

(2 citation statements)

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“…The Langmuir-Blodgett technique is an important method to produce macroscopic materials organized on the molecular scale [1][2][3][4][5]. This approach allows amphiphilic molecules to be oriented at the air-water interface and then transferred sequentially onto a solid support [6][7][8][9][10][11][12][13][14][15].…”

Section: Preparation and Self-assembly Of Some Functionalized Lb Filmsmentioning

confidence: 99%

Advances in Design and Self-Assembly of Functionalized LB Films and Supramolecular Gels

Jiao¹,

Xing²,

Ma³

et al. 2016

Advances in Colloid Science

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The recent progress in functionalized LB ilms and supramolecular gels varies and occupies various ields. Self-assembly technique is playing an important role in preparing well-deined multilevel nanostructures and the functionalized nanomaterials with the designed and controlled properties. In this chapter, various kinds of functionalized LB ilms and supramolecular gels, including gold nanoparticles, inorganicorganic hybrid composites, and graphene oxide nanocomposites, have been demonstrated and analyzed. We show main research contributions in recent years in two sections preparation and self-assembly of some functionalized LB ilms and preparation and self-assembly of some functionalized supramolecular gels. The above research work may give the potential perspective for the design and preparation of new selfassembly nanomaterials. Future research on preparation of LB ilms and supramolecular gels will depend on the novel applications and special nanostructures in order to produce novel functional nanomaterials and devices.Keywords: LB ilm, supramolecular gel, self-assembly, nanomaterials, nanostructures, properties . IntroductionThe recent progress in functionalized LB ilms and supramolecular gels is varied and occupies various ields. It is well known that the self-assembly techniques demonstrate important and crucial role to prepare various functionalized nanostructures and nanomaterials with the preferred properties. In comparison with the conventional self-assembly process of amphiphiles in bulk or at interfaces, the self-assembly process of inorganic-organic hybrids, © 2016 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.© 2017 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.nanoparticles and colloidal microspheres, and supramolecular nanostructures show special properties, especially in preparing complicated nanocomposites or nanomaterials.In the recent reports in our groups, some systems, including LB ilms and supramolecular gels, have been designed and characterized. In addition, some useful analytical techniques and synthetic treatments applied in supramolecular self-assembly ield have been highlighted and analyzed. In the present chapter, we summarize main work contributions in recent years in two parts preparation and self-assembly of some functionalized LB ilms and preparation and self-assembly of some functionalized supramolecular gels. . Preparation and self-assembly of some functionalized LB ilmsThe Langmuir-Blodget technique is an important method to produce macroscopic materials organized on the molecular scale [ -]....

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Section: Preparation and Self-assembly Of Some Functionalized Lb Filmsmentioning

confidence: 99%

Advances in Design and Self-Assembly of Functionalized LB Films and Supramolecular Gels

Jiao¹,

Xing²,

Ma³

et al. 2016

Advances in Colloid Science

View full text Add to dashboard Cite

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“…In these systems, lipids are either tethered to the substrate [18][19][20][21][22], or stabilized on it due to strong adhesive interactions [19,[23][24][25][26]. In this regard, it can be deemed most efficient to employ the Langmuir-Blodgett (LB) and Langmuir-Schaeffer (LS) methods, which make possible to form and to study lipid bilayers, stable if they are kept in contact with an aqueous phase, with various inclusions, on virtually any solid hydrophilic supports [19,20,[27][28][29][30][31][32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Photosensitized Degradation of Model Lipid Membranes based on 1-palmitoyl-2-oleyl-phosphatidylcholine (POPC)

Shokurov

Novak²,

Grin³

et al. 2018

Prot Met Phys Chem Surf

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Abstract⎯In this work, we study the interaction of a well-known photosensitizer, MePha, with models of biological membrane (Langmuir monolayers and Langmuir-Schaeffer planar bilayers) based on one of the most important natural lipid, POPC, for the subsequent investigation of photodestruction processes in a context of photodynamic therapy treatment. Changes of macroscopic properties and morphology of POPC/MePha model membranes upon irradiation by visible light are recorded by means of contact angle measurements and atomic force microscopy, demonstrating clearly the possibility to use these methods for the study of photodestruction of artificial lipid membranes on solid substrates, but also for a comparative study of the efficiency of novel photosensitizers.

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Proof of pore formation and biophysical perturbations through a 2D amoxicillin-lipid membrane interaction approach

Lopes

Nunes

Fontaine

et al. 2017

Biochimica et Biophysica Acta (BBA) - Biomembranes

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Amoxicillin is a worldwide used antibiotic, and it is classified as a first-line drug against Helicobacter pylori gastric infections. However, the current treatment of these infections has several limitations, such as the side effects and the low therapeutic compliance. Amoxicillin has been associated with gastrointestinal and renal side effects, with higher toxicity when the pH is lower. By considering this association and the well-known pH gradient of the gastric mucosa, this work aims to evaluate the influence of pH on the toxicity of amoxicillin. For that purpose, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) monolayers were used since phosphatidylcholines are the most common phospholipid headgroup of biological membranes. To have insight of the effects of amoxicillin, different techniques were employed, namely, isotherm measurements, infrared reflection-absorption spectroscopy, grazing incident X-ray diffraction and Brewster angle microscopy. The monolayers of DPPC spread onto different buffer solutions (pH1.2, pH5 and pH7.4) showed different structural and packing properties. The interaction with amoxicillin also depended on the pH. At pH7.4, the highest effect was visualized at lower pressures, with partial restoration of the biophysical properties of the monolayer at 30 mN.m. A higher perturbation is shown at acidic pH, in which pores were visualized by Brewster angle microscopy. These perturbations may ultimately be related with amoxicillin toxicity.

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Influence of oxidized lipids on palmitoyl-oleoyl-phosphatidylcholine organization, contribution of Langmuir monolayers and Langmuir–Blodgett films

Cited by 14 publications

References 46 publications

Advances in Design and Self-Assembly of Functionalized LB Films and Supramolecular Gels

Advances in Design and Self-Assembly of Functionalized LB Films and Supramolecular Gels

Photosensitized Degradation of Model Lipid Membranes based on 1-palmitoyl-2-oleyl-phosphatidylcholine (POPC)

Proof of pore formation and biophysical perturbations through a 2D amoxicillin-lipid membrane interaction approach

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