Influence of oxytetracycline and oxolinic acid on the immune response of rainbow trout (Oncorhynchus mykiss)

Safety of Aquaflor (Florfenicol, 50% Type A Medicated Article), Administered in Feed to Channel Catfish, Ictalurus punctatus

“…Carp and rainbow trout head kidney lymphoid cell proliferation following mitogen stimulation was reduced by in vitro florfenicol treatment (20,31). Both oxolinic acid and oxytetracycline suppressed components of the humoral and cellular immune response of carp and rainbow trout (12,21,26). Unlike oxolinic acid or oxytetracycline, florfenicol therapy did not suppress circulating leucocyte levels nor antibody production in rainbow trout (21,22).…”

The influence of in vitro and in vivo exposure to antibiotics on mitogen-induced proliferation of lymphoid cells in rainbow trout (Oncorhynchus mykiss)

“…Some drugs have been shown to interfere with immunological processes (Grondel et al, 1985;Lundén et al, 1998Lundén et al, , 1999. The interaction of antibiotics with lymphoid tissue may alter the functions and balances of the immune system and induce undesirable e#ects like immunosuppression, uncontrolled cell proliferation, alterations of other host defence mechanisms against pathogens and can even induce neoplasia (Anderson & Zeeman, 1995).…”

Antibiotics in Aquaculture – Use, Abuse and Alternatives

“…Regardless of the route of administration, the serum immunoglobulin levels were drastically decreased by oxytetracycline (Rijkers et al, 1981). Lundên and collaborators studied the effects of several antibiotics, including oxolinic acid, oxytetracycline, florfenicol and trimethoprim in combination with sulfadiazine, on different aspects of immune function in rainbow trout (Oncorhynchus mykiss) (Lunden et al, 1998;Lunden et al, 1999;Lunden & Bylund, 2002). The results for oxolinic acid and oxytetracycline, both in vitro and in vivo, indicated that these antibiotics suppressed the mitogenic response of head kidney lymphoid cells.…”