Influence of particle size on the SARS-CoV-2 spike protein detection using IgG-capped gold nanoparticles and dynamic light scattering

Ligiéro, Carolina B. P.; Fernandes, Tamires S.; D’Amato, Dayenny L.; Gaspar, Francisco V.; Duarte, Paola S.; Strauch, Marcelo A.; Fonseca, Juliana Garcia da Silva; Meirelles, Leonardo G.R.; Silva, Patrícia Bento da; Azevedo, Ricardo Bentes; Martins, Glêndara Aparecida de Souza; Archanjo, Bráulio S.; Buarque, Camilla D.; Machado, Giovanna; Percebom, Ana Maria; Ronconi, Célia M.

doi:10.1016/j.mtchem.2022.100924

Cited by 21 publications

(14 citation statements)

References 67 publications

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“…The functionalization of s-MS and r-MS was carried out following procedures that were well established by our group for different materials. ,,,,− The activated s-MS (0.60 g) and r-MS (0.40 g) materials were added to a bottom round flask containing PhMe (60 mL) and TESBN (2.0 mL), respectively, under stirring. The dispersions were maintained under reflux and N 2 atmosphere for 2 h. Then, an aliquot of each dispersion (1.5 mL) was removed from the system with subsequent addition of TESBN (0.6 mL).…”

Section: Methodsmentioning

confidence: 99%

Responsive Supramolecular Devices Assembled from Pillar[5]arene Nanogate and Mesoporous Silica for Cargo Release

Silva

Costa

Fernandes

et al. 2022

ACS Appl. Nano Mater.

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In this work, cationic switchable pillar[5]arene nanogates that bear an imidazolium scaffold (MIP5+) were constructed, and these nanogates were used to electrostatically interact with negatively charged spherical mesoporous silica nanoparticles (96.0 ± 1.0 nm) and rod-shaped silica particles (391.0 ± 0.2 nm in length and 219 in width), which are both functionalized with carboxypropyl groups. The nanochannels of silica-based materials were used as containers to store the anticancer drug doxorubicin (DXR) trapped by the nanogate. Under physiological conditions (pH = 7.4), DXR molecules were firmly trapped in the nanochannels of the spherical and rod-shaped containers without any premature release, demonstrating that the nanogate was efficient in sealing the nanopores. Under acidic conditions (pH = 4.5), the carboxypropyl groups were protonated, and the electrostatic interactions between the containers and the nanogates were disrupted, releasing the drug. In vitro studies were performed to explore the differences between N-methylimidazolium-pillar[5]arene nanogate mounted on DXR-loaded spherical and rod-shaped containers and the resulting cytotoxicity effect against human breast adenocarcinoma cells and cellular uptake. A higher cytotoxicity effect and better cellular uptake were detected for the nanogate on DXR-loaded rod-shaped silica containers. Additionally, this device presents a lower uptake rate by nontumor cells than that of free DXR. Therefore, our findings indicate that the rod shape of mesoporous silica in nanogated devices is important due to the cytotoxicity effect and cellular uptake and should be further explored in drug delivery systems.

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Section: Methodsmentioning

confidence: 99%

Responsive Supramolecular Devices Assembled from Pillar[5]arene Nanogate and Mesoporous Silica for Cargo Release

Silva

Costa

Fernandes

et al. 2022

ACS Appl. Nano Mater.

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“…These surface plasmonic enhancement strategies have also been employed for SARS-CoV-2 detections in combination with smartphones. Noble metal NPs possess remarkable plasmonic properties [ 76 , 77 ], which can be modified with bioreceptors and show plasmonic resonance change after interacting with the antigen of SARS-CoV-2 [ 78 ]. For instance, Olalla Calvo-Lozano et al employed an electron beam-deposition system and fabricated 1 nm of titanium (Ti) and 49 nm of gold (Au) sensor chips by metal evaporation [ 79 ].…”

Section: Smartphone-based Optical Analysismentioning

confidence: 99%

Achieving broad availability of SARS-CoV-2 detections via smartphone-based analysis

Sun

Mei

et al. 2023

TrAC Trends in Analytical Chemistry

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“…For example, Hryniewicz 70 developed a conductive polymer nanosensor based on Au nanoparticles to monitor human SARS-CoV-2 seroconversion, which can be used to aid in the diagnosis of coronavirus with improved sensitivity. Ligiero 71 reported that the increase in the particle size of Au nanoparticles would lead to an increase in the hydrodynamic diameter during the antigen−antibody interactions in conditions containing SARS-CoV-2 S-protein, for which the SARS-CoV-2 S-protein was found in less than 5 min. These works are of good relevance in the context of the current severe coronavirus epidemic.…”

Section: Photoresponsive Liposomes Based On Au Nanoparticlesmentioning

confidence: 99%

Recent Development of Photoresponsive Liposomes Based on Organic Photosensitizers, Au Nanoparticles, and Azobenzene Derivatives for Nanomedicine

Pan

et al. 2022

ACS Appl. Nano Mater.

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Photoresponsive liposomes are controlled-release liposomes modified by photoresponsive materials. They use light with high spatial and temporal precision as a means of regulation. After excitation by light at appropriate wavelengths, photoresponsive liposomes can influence the permeability of phospholipid bilayers through the photothermal or photoisomerization effect of photoresponsive materials. The photothermal effect causes the phospholipid layer to become dispersed by local heating, and the photoisomerization effect modulates the release behavior by establishing permeation channels on the phospholipid layer through changes in the dipole moments of azobenzene derivatives. Currently, photoresponsive liposomes are widely used as a cutting-edge strategy for nanomedicine. In this paper, three types of photoresponsive liposomes based on organic photosensitizers, Au nanoparticles, and azobenzene derivatives with abundant research reports were introduced based on the differences in the photoresponse principles and forms of different photoresponsive materials. This review aims to reflect the differences in the structures, properties, photoresponsive materials, and principles of action of different photoresponsive liposomes. Moreover, this work outlines the current status of their application in the field of nanomedicine.

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Influence of particle size on the SARS-CoV-2 spike protein detection using IgG-capped gold nanoparticles and dynamic light scattering

Cited by 21 publications

References 67 publications

Responsive Supramolecular Devices Assembled from Pillar[5]arene Nanogate and Mesoporous Silica for Cargo Release

Responsive Supramolecular Devices Assembled from Pillar[5]arene Nanogate and Mesoporous Silica for Cargo Release

Achieving broad availability of SARS-CoV-2 detections via smartphone-based analysis

Recent Development of Photoresponsive Liposomes Based on Organic Photosensitizers, Au Nanoparticles, and Azobenzene Derivatives for Nanomedicine

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