Influence of patient age on the growth and transfer of blastocyst-stage embryos

Shapiro, B.S.; Richter, Kevin S.; Harris, D.; Daneshmand, S.T.

doi:10.1016/s0015-0282(01)03251-4

Cited by 47 publications

(26 citation statements)

References 42 publications

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“…Similar to our findings, several other studies have also shown a decrease in the blastocyst development rate with increasing female age [14,20,42]. Other than advanced maternal age, no clearly established factor has been described for the development of embryos with poor morphology.…”

Section: Discussionsupporting

confidence: 91%

Patient selection criteria for blastocyst transfers in extended embryo culture programs

Braga

Setti

Figueira

et al. 2012

J Assist Reprod Genet

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Purpose To identify the correlation between different cycles, patient factors and blastocyst characteristics. Methods The study included 420 patients undergoing ICSI cycles and 2781 graded blastocysts, which took into account the blastocyst quality. The correlations between the blastocyst parameters and the patient and cycle characteristics were assessed. Results The blastocyst development was negatively correlated with the maternal age, BMI and dose of FSH. The ICM was negatively correlated with the FSH dose, whereas the TE quality was influenced by the FSH dose, the maternal age and the number of retrieved oocytes. The embryo morphology on days two and three may predict the blastocyst developmental competence. Conclusions Older patients and patients with high BMI should not be included in extended embryo culture programmes. The extended culture may not favour embryos with poor morphology on days two and three of development. Additionally, a lower ovarian stimulation and decreased oocyte yields may lead to the development of high-quality blastocysts.

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Section: Discussionsupporting

confidence: 91%

Patient selection criteria for blastocyst transfers in extended embryo culture programs

Braga

Setti

Figueira

et al. 2012

J Assist Reprod Genet

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show abstract

“…It has been shown that blastocyst development rates tend to decrease with increased donor age (22). ''Surplus'' embryos from patients who had completed their fertility treatment and had sufficient pronuclear-stage embryos were used in the present study, with consent and ethical approval.…”

Section: Discussionmentioning

confidence: 99%

Selection of high-potential embryos by culture in poly(dimethylsiloxane) microwells and time-lapse imaging

Hashimoto

Kato

Saeki

et al. 2012

Fertility and Sterility

117

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“…Although the probability of multiple gestation is reduced among older IVF patients, the risks associated with carrying multiples increase with age. Although these patients are much less likely to produce embryos able to develop into high-quality blastocysts in vitro, those that do may achieve IRs and PRs similar to those of younger patients (68). Viable PRs of >50% have been reported for single-blastocyst transfers to patients aged 36-42 years (69) and 38-40 years (24).…”

Section: Indications For Esetmentioning

confidence: 99%