Influence of pegylated interferon-α therapy on plasma levels of citrulline and arginine in melanoma patients

Fekkes, Durk; Bannink, M.; Kruit, Wim; Gool, Arthur R. Van; Mulder, Paul; Sleijfer, Stefan; Eggermont, Alexander M.M.; Stoter, G.

doi:10.1007/s00726-006-0284-3

Cited by 13 publications

(13 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, the ratio of the amino acids citrulline and arginine (Cit‐Arg ratio) was calculated as an index of NO synthesis. This method has been reported to be sufficiently accurate and reproducible, and it can be used as an effective index to reflect the NOS‐NO system activity . Furthermore, we selected a special subtype of depression (MDD) for study, using the same SSRI monotherapy.…”

Section: Discussionmentioning

confidence: 99%

The changes in, and relationship between, plasma nitric oxide and corticotropin‐releasing hormone in patients with major depressive disorder

Zhang

Rao

et al. 2017

Clin Exp Pharma Physio

View full text Add to dashboard Cite

SummaryThere is strong evidence of roles of the hypothalamus‐pituitary‐adrenal axis and nitric oxide (NO) synthase‐NO system in depression, but the relationship between them is unknown. The aim of this study, therefore, was to elucidate whether there is any correlation between NO and corticotropin‐releasing hormone (CRH) in major depressive disorder (MDD) patients. In 16 outpatients with MDD and 18 healthy controls, the plasma amino acids citrulline (Cit) and arginine (Arg) were determined by high‐performance liquid chromatography, and CRH levels was measured by radioimmunoassay. The Cit/Arg ratio was calculated as an index of NO synthesis. Correlations between NO and CRH were examined with the Spearman test. Before treatment, no significant correlation was observed between the plasma NO level and CRH levels in MDD patients. The plasma NO levels were significantly higher in MDD patients. A significant correlation was found between NO levels and Hamilton Depression Rating Scale (HAMD) scores in MDD patients. The plasma CRH levels were significantly higher in MDD patients than in controls. After monotherapy for 2 months, the NO levels had dramatically declined but were also higher than those in the controls. This study is the first report of the absence of a significant correlation between plasma NO and CRH levels, although both levels are elevated in MDD patients. Furthermore, the strong links between the plasma NO levels and the HAMD scores, as well as the increased NO reduction after remission, suggest that NO plays a key role in depression and may be an indicator of therapeutic success.

show abstract

Section: Discussionmentioning

confidence: 99%

The changes in, and relationship between, plasma nitric oxide and corticotropin‐releasing hormone in patients with major depressive disorder

Zhang

Rao

et al. 2017

Clin Exp Pharma Physio

View full text Add to dashboard Cite

show abstract

“…In addition, the symptomatic and euthymic subgroup of BP-I patients on lithium monotherapy both demonstrated a lower Cit-Arg ratio as compared to healthy controls as well as to the two patient groups with depressive disorders. This ratio is regarded as an index of the NO synthesis [13] and/or NO synthase activity [12] and thus, NO formation may be endangered in bipolar patients.…”

Section: Discussionmentioning

confidence: 99%

“…The NO synthesis was approximated by calculation of the ratio between the plasma levels of the amino acids citrulline and arginine (Cit-Arg ratio). Both NO and citrulline are formed from arginine, a reaction catalyzed by the enzyme NO synthase, and the Cit-Arg ratio is regarded as an index of the NO synthesis [12,13] .…”

Section: Introductionmentioning

confidence: 99%

Nitric Oxide and Neopterin in Bipolar Affective Disorder

et al. 2006

Self Cite

View full text Add to dashboard Cite

Background: There is an increasing interest in the role of nitric oxide (NO) and pterines in the pathophysiology of neuropsychiatric disorders. The results so far show an inconsistent pattern. Methods: In the present study, neopterin and a measure of NO synthesis in plasma of symptomatic and euthymic bipolar affective patients were compared to those of patients with a major depression and healthy controls. As an index of NO synthesis, the ratio of the amino acids citrulline and arginine (Cit-Arg ratio) was calculated. Neopterin is a bypass product in the synthesis of tetrahydrobiopterin, which is a cofactor of NO synthase. Results: The results indicate that both neopterin and the Cit-Arg ratio are decreased in bipolar affective patients, irrespective of their symptomatic status. In addition, an association between the values of the Cit-Arg ratio and the neopterin level was observed, which is suggestive for a low tetrahydrobiopterin activity. Conclusion: NO formation may be endangered in bipolar affective disorder.

show abstract

“…In this process tetrahydrobiopterin (BH4) is a necessary cofactor. We have shown that the ratio of the plasma concentrations of citrulline (Cit) and arginine (Arg), the so-called Cit/Arg ratio, can be regarded as an index of NO synthesis (Fekkes et al 2007). …”

Section: Introductionmentioning

confidence: 99%

Plasma levels of nitric oxide related amino acids in demented subjects with Down syndrome are related to neopterin concentrations

et al. 2009

Self Cite

View full text Add to dashboard Cite

Subjects with Down syndrome (DS) have abnormalities in virtually all aspects of the immune system and almost all will be affected with Alzheimer’s disease (AD). It is thought that nitric oxide (NO) is involved in the pathophysiology of AD. In the present study, including a total of 401 elderly DS subjects, the spectrum of plasma amino acids and neopterin was investigated and related to development of AD. Concentrations of nearly all amino acids in DS subjects differed significantly from those of healthy controls. Neopterin was increased in DS subjects, especially in dementia. The production of NO as reflected by an increased citrulline/arginine ratio (Cit/Arg ratio) was enhanced during development of clinical dementia. Neopterin concentrations correlated to the Cit/Arg ratio only in the group of prevalent demented subjects (ρ = 0.48, P = 0.006). The results of this study are suggestive for an increase in oxidative processes in DS subjects with AD.

show abstract

Influence of pegylated interferon-α therapy on plasma levels of citrulline and arginine in melanoma patients

Cited by 13 publications

References 30 publications

The changes in, and relationship between, plasma nitric oxide and corticotropin‐releasing hormone in patients with major depressive disorder

The changes in, and relationship between, plasma nitric oxide and corticotropin‐releasing hormone in patients with major depressive disorder

Nitric Oxide and Neopterin in Bipolar Affective Disorder

Plasma levels of nitric oxide related amino acids in demented subjects with Down syndrome are related to neopterin concentrations

Contact Info

Product

Resources

About