Influence of peptide dendrimers and sonophoresis on the transdermal delivery of ketoprofen

Abstract

Please cite this article as: Manikkath, Jyothsna, Hegde, Aswathi R., Kalthur, Guruprasad, Parekh, Harendra S., Mutalik, Srinivas, Influence of peptide dendrimers and sonophoresis on the transdermal delivery of ketoprofen.International Journal of Pharmaceutics http://dx.doi. org/10.1016/j.ijpharm.2017.02.002 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. dendrimer showed comparable absorption and plasma drug levels with oral route. The excised mouse skin after in vivo permeation study with dendrimers and ultrasound did not show major toxic reactions. This study demonstrates that arginine terminated peptide dendrimers combined with sonophoresis can effectively improve the transdermal permeation of ketoprofen.

Recent advances in ultrasound-based transdermal drug delivery

“…37 They discovered the presence of combination and simultaneous resonances, which are unique to dual-frequency ultrasound, and further examined the applicability of dual-frequency ultrasound to control chaotic bubble oscillations. 38 The authors emphasized that the regulation of chaotic bubble oscillations allowed consistent manipulability of acoustic cavitation effects and consequently enhanced sonophoretic percutaneous transport. These studies on bubble dynamics under the influence of dual-frequency ultrasound can allow further research into the enhanced control of acoustic cavitation effects for sonophoretic transdermal drug delivery.…”

“…Manikkath et al 55 investigated an alternative potential for the sonophoretic delivery of drugs through nanoparticles by testing the permeability of ketoprofen with peptide dendrimers on mouse skin in vitro and in vivo and comparing these results with that of orally administered ketoprofen. Peptide dendrimers are hyperbranched nanopolymeric structures with a variety of possible charges.…”

NMR studies of excluded volume interactions in peptide dendrimers

“…More general peptide dendrimers could contain not only lysine but also other amino acid residues. Such branched peptides were synthesized 18 – 20 and used for several biomedical applications including drug and gene delivery, artificial enzymes, antimicrobial peptides etc 21 – 26 . In the last years the properties of the group of peptide dendrimers of the same topology but of different amino acid composition have been compared for possible use in DNA and siRNA delivery 27 , 28 .…”

Microneedle-Assisted Percutaneous Delivery of a Tetramethylpyrazine-Loaded Microemulsion

“…Passive skin penetration enhancement protocols usually involve the application of nano-scale carriers, such as microemulsions, vesicles, and nanoparticles, to facilitate drug penetration through the skin [ 2 , 3 , 4 ]. Active skin penetration enhancement typically requires perturbing the reversible barrier function of the SC using mechanical force (microneedles), ultrasound (sonophoresis), high voltage pulses (electroporation), or the application of a small electrical potential difference (iontophoresis) to drive ionic drugs through hair follicles [ 5 , 6 , 7 ]. Efforts to improve skin permeation efficiency have led to combining passive and active enhancement techniques.…”