Influence of peptides on reduced response of rats to electric footshock after acute administration of morphine

Gispen, Willem Hendrik; Greidanus, T.B. van Wimersma; Waters-Ezrin, Ch.; Zimmermann, E.; Krivoy, William A.; Wied, D. de

doi:10.1016/0014-2999(75)90143-0

Cited by 43 publications

(11 citation statements)

References 14 publications

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“…Recent reports show that with a rise in the concentration of plasma corticosteroids, animals become less sensitive to opioid agonists but more sensitive to opioid antagonists (Gebhart & Mitchell, 1972;Gispen, Van Wimersma Greidanus, Waters-Ezrin, Zimmermann, Krivoy & De Wied, 1975;Harris, Loh & Way, 1976). This ability of corticosteroids to affect the activity of opioids, and of opioids to affect the release of anterior pituitary hormones, suggests that the degree of analgesia produced by opioids is a balance of two opposing actions.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Opiate Receptor Agonists and Antagonists on the Stress‐induced Secretion of Corticosterone in Mice

Gibson

Ginsburg

Hall

et al. 1979

British J Pharmacology

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1 Intraperitoneal administration of normorphine, morphine or naloxone or exposure to ether vapour for 1 min, elevated plasma corticosteroid concentrations in mice. 2 Injection of saline or exposure to ether vapour rendered mice less sensitive to a subsequent exposure to ether vapour 15 min later. 3 Treatment with normorphine (50 mg/kg) potentiated the corticosteroid response to ether stress whilst pentazocine (20 mg/kg), naltrexone (10 mg/kg), morphine (24 mg/kg), levorphanol (20 mg/kg) and naloxone (50 mg/kg) prevented the stress-induced elevation of plasma corticosteroids. 4 Both naloxone and morphine inhibited the potentiation by normorphine of the response to ether, the dose of naloxone required being higher than that for inhibition of normorphine analgesia. 5 It is concluded that endogenous opioid peptides may be involved in the control of the response to ether stress in mice.

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Section: Discussionmentioning

confidence: 99%

The Effects of Opiate Receptor Agonists and Antagonists on the Stress‐induced Secretion of Corticosterone in Mice

Gibson

Ginsburg

Hall

et al. 1979

British J Pharmacology

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“…The fact that ACTH-fragment 4-10, which has no influence on the adrenal cortex, exerted the same effect as that of whole molecule suggests that the observed mnemonic effect is independent of adrenocortical activity. However, ACTH and its analogs have been reported to interfere with the analgesic action of morphine (Gispen et al, 1975 and increase punishment effects (de Wied, 1974;Garrud, 1975Garrud, , 1976Gray et al, 1971). Since, retrieving an item from memory amounts to activating its internal representation, the enhanced aversive memory retrieval following systemic administration of ACTH and ACTH 4-10 may have been mediated by an aversive activating process.…”

Section: Discussionmentioning

confidence: 93%

Effects of ACTH and ACTH 4?10 on aversive memory retrieval in rats

Kumar

Karanth

1995

J. Neural Transmission

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The aim of the study was to examine whether ACTH and ACTH-fragment 4-10, given before the test would produce a selectively enhanced retrieval of aversive memories, in the same way as preexposure to inescapable footshocks, in rats. For this purpose animals conditioned in a T-maze with appetitive (10% sucrose) and aversive (2.0 mA footshock) events were administered (s.c.) a single dose of 10, 20 or 40 ug/rat of ACTH or 5, 10 or 20 ug/rat of ACTH-fragment 4-10, 20-min before testing. The retention test conducted in the same training apparatus 72-hrs after conditioning showed a dose-dependent increase in latencies to enter the previously shocked goalarm with the absence of such a difference in responding to the nonshocked goalarm, in ACTH and ACTH 4-10 treated groups. This differential response was not observed in saline treated rats. This effect of peptides on memory retrieval was similar to that seen following inescapable footshock in rats. The results suggest the possible involvement of ACTH in the differential enhancement of memory of helplessness condition.

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“…[8,9]). Additionally, the melanocortin system interacts with the opiate system; it can block morphine‐induced depression of evoked potential in frog and cat nervous tissue [10] and it attenuates the analgesia induced by morphine [11–14]. In addition, melanocortin 4 receptor (MC4R) antagonists have been shown to attenuate morphine anti‐nociceptive tolerance [15].…”

Section: Introductionmentioning

confidence: 99%

Effects of melanocortin‐4 receptor (MC4R) antagonist on neuropathic pain hypersensitivity in rats – A systematic review and meta‐analysis

Korczeniewska

Kohli

Rider

et al. 2021

European J Oral Sciences

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Melanocortin‐4 receptor (MC4R) has been investigated as a potential drug target for the treatment of neuropathic pain. The objective of the study was to systematically identify the effects of MC4R antagonists on hypersensitivity in rat models of neuropathic pain. A systematic search was conducted using the following databases: WoS, PubMed, SCOPUS, and MEDLINE. Inclusion criteria were: rat hypersensitivity induced by models of neuropathic pain with reported effects of MC4R antagonist. Two researchers performed the selection process and data extraction. SYRCLE risk of bias tool was used. Standard mean differences (SMD) were calculated and pooled by meta‐analysis using random effect models. Ten articles met the eligibility criteria and were included in the systematic review and meta‐analysis. The results reveal that, in animals exposed to neuropathic pain, administration of MC4R antagonists significantly increased paw withdrawal threshold (SHU9119 SMD = 1.67, 95% CI: [0.91, 2.44], I2 = 0%; HS014 SMD = 2.2, 95% CI: [0.53, 3.87], I2 = 71%) and heat withdrawal latency (HS014 SMD = 3.35, 95% CI: [0.56, 6.14], I2 = 83%) compared to vehicle‐treated animals. MC4R antagonists are effective in the alleviation of hypersensitivity in rodent neuropathic pain models. SHU9119 and HS014 antagonists showed the most prominent results. However, further investigation is needed to determine the optimal dose and time of treatment.

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Influence of peptides on reduced response of rats to electric footshock after acute administration of morphine

Cited by 43 publications

References 14 publications

The Effects of Opiate Receptor Agonists and Antagonists on the Stress‐induced Secretion of Corticosterone in Mice

The Effects of Opiate Receptor Agonists and Antagonists on the Stress‐induced Secretion of Corticosterone in Mice

Effects of ACTH and ACTH 4?10 on aversive memory retrieval in rats

Effects of melanocortin‐4 receptor (MC4R) antagonist on neuropathic pain hypersensitivity in rats – A systematic review and meta‐analysis

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