This study was conducted to investigate the relationship between school nurses's perception level and performance level about headache management for children and adolescents with headache in elementary school, middle school, and high school. The subjects of this study were 250 school nurses working in elementary, middle, and high schools in G metropolitan city, who had a nurse's license and participated in the training course of the G metropolitan office of education. After excluding survey responses with incomplete information, there were 176 participants in total. For the data collection, a structured questionnaire was used, and the collected data were performed using the SPSS 22.0 for Windows program, average analysis, frequency analysis, ANOVA, Pearson's correlation, and multiple regression analysis. Participants were 176 school nurses; The average scores for perception level and performance level of headache management were 3.88 ± 0.33 (range 1-5) and 3.79 ± 0.40 (range 1-5), respectively. School nurses's perception level and performance level of headache management showed a statistically significant correlation (r = 0.50, p <0.001). As a result of multiple regression analysis, it can be seen that the level of perception of headache management by school nurses affects the level of performance of headache management by school nurses, and this explanatory power was 24.5%. These results showed that the performance levels of school nurses on headache management for students with headache were lower than the perception levels of them, and indicated that the performance levels of school nurses on headache management for students with headache increased as the perception levels of them increased. Therefore, it suggests to develop various training programs for effective headache management of school nurses and to develop programs and standardized guidelines to manage health problems, including headaches among children and adolescents.