Influence of perinatal deltamethrin exposure at distinct developmental stages on motor activity, learning and memory

Xi, Chuchu; Yang, Zhao; Yu, Yaoliang; Li, Shaoheng; He, Jing; El-Aziz, Tarek Mohamed Abd; Zhao, Fang; Cao, Zhengyu

doi:10.1016/j.ecoenv.2022.113460

Cited by 9 publications

(3 citation statements)

References 77 publications

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“…So how to optimize the selection of the control group for SHR rats is worthy of further study. Perinatal exposure could lead to ADHD-like hyperactivity and impulsivity, and loss of dentate gyrus neurons in male offspring (Xi et al, 2022). Previous studies have shown that 20-25% of neurons may be dead or severely dysfunctional in children with ADHD (Derbyshire and Maes, 2023).…”

Section: Discussionmentioning

confidence: 99%

Rehmanniae Radix Preparata ameliorates behavioral deficits and hippocampal neurodevelopmental abnormalities in ADHD rat model

Sun,

Yuan,

Wang

et al. 2024

Front. Neurosci.

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ObjectivesAbnormal hippocampal neurodevelopment, particularly in the dentate gyrus region, may be a key mechanism of attention-deficit/hyperactivity disorder (ADHD). In this study, we investigate the effect of the most commonly used Chinese herb for the treatment of ADHD, Rehmanniae Radix Preparata (RRP), on behavior and hippocampal neurodevelopment in spontaneously hypertensive rats (SHR).MethodsBehavior tests, including Morris water maze (MWM) test, open field test (OFT) and elevated plus maze (EPM) test were performed to assess the effect of RRP on hyperactive and impulsive behavior. Hippocampal neurodevelopment was characterized by transmission electron microscopy, immunofluorescence, Golgi staining and Nissl staining approaches. Regulatory proteins such as Trkb, CDK5, FGF2/FGFR1 were examined by Western blot analysis.ResultsThe results showed that RRP could effectively control the impulsive and spontaneous behavior and improve the spatial learning and memory ability. RRP significantly reduced neuronal loss and increased the number of hippocampal stem cells, and promoted synaptic plasticity. In addition, FGF/FGFR signaling was upregulated after RRP treatment.ConclusionRRP can effectively reduce impulsive and spontaneous behavior and ameliorate hippocampal neurodevelopmental abnormalities in ADHD rat model.

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Section: Discussionmentioning

confidence: 99%

Rehmanniae Radix Preparata ameliorates behavioral deficits and hippocampal neurodevelopmental abnormalities in ADHD rat model

Sun,

Yuan,

Wang

et al. 2024

Front. Neurosci.

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“…In the present study, total protein levels were increased following deltamethrin treatment without significant changes in uric, creatinine, albumin, and globulin levels. However, a study conducted by Xi et al (2022) investigated the effects of prenatal deltamethrin exposure and found that it led to decreased protein levels of methyl-D-aspartate receptors subunits 2A and 2B in the hippocampus and cortices of the cerebrum in male offspring. Additionally, deltamethrin increased the levels of urea and creatinine in the serum of rats, resulting in renal injury (Fetoui et al, 2010; Sankar et al in 2012).…”

Section: Discussionmentioning

confidence: 99%

Biomarkers of oral subacute toxicity of deltamethrin in exposed male Albino rats

Elbanna,

Osman,

Salama

2023

Toxicol Ind Health

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Deltamethrin is one of the most effective pyrethroid compounds, widely employed in veterinary medicine, public health, and farming. Deltamethrin-triggered oxidative stress largely causes serious harm to an organism. Acute toxicity of this compound was extensively investigated, while less information is available on its oral sub-acute effects. This study assessed, in the male Albino rats, the effects of oral gavage of either 0.874 mg/kg (0.01 LD50) or 8.740 mg/kg (0.10 LD50) of deltamethrin for successive 14 days to investigate its effects on biomarkers and to detect the tissue injury in rats following subacute deltamethrin treatment. It was found that levels of glutathione peroxidase, superoxide dismutase, and catalase in the brain, kidney, and liver, alkaline phosphatase (ALP), and uric acid in serum, hematocrit, mean corpuscular volume (MCV), white blood cells (WBC)s, eosinophils, and basophils were significantly reduced compared with untreated rats. However, when rats were treated with deltamethrin for successive 14 days, alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) activities in serum and the levels of thiobarbituric acid reactive substances (TBARs) in brain, kidney, and liver, red blood cell distribution width (RDW-CV), total protein, monocytes, and basophils and the ratios of neutrophils to lymphocytes, an aggregated marker of systemic inflammation and systemic immune inflammation indexes, significantly increased compared with the control group. Histologic lesions were observed in the liver, kidney, brain, testis, and epidemies in rats exposed to subacute deltamethrin for 14 days, and most tissues of rats treated with 0.10 LD50 of deltamethrin were more affected than those treated with 0.01 LD50. These findings strongly suggest that subacute exposure to deltamethrin caused significant systemic toxicity through oxidative stress resulting in biochemical and histological changes in the studied tissues. These findings highlight the potential harmful effects of deltamethrin and emphasize the importance of understanding the subacute effects of this compound, particularly in the context of veterinary medicine, public health, and farming.

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“…Godinho et al showed that perinatal exposure to selected type I (d-allethrin) and type II (cypermethrin) pyrethroids resulted in physical and sensory-motor changes in weaned pups and persistent behavioral effects during offspring development, indicating that Cyp has a significant capacity to cause neurotoxicity over time (21). Another study found that rats exposed to cyhalothrin exhibited potential hyperactivity to avoid learning (22), whereas rats treated with deltamethrin did not exhibit hyperactivity (23). One study used a biologically based dose-response model to examine the relationship between high hydrochloric acid and developmental neurotoxicity, and they believed that, applied models can enhance the credibility of studies from animals to humans and can test whether the mode of action of a poison in animals is relevant to humans (24).…”

Section: Neurotoxicitymentioning

confidence: 99%

Toxicity and Health Hazards of Pyrethroid Pesticides

Rah

Rustika

2022

Sci Insights

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Worldwide, pyrethroid pesticides have been widely used in the control of agricultural pests and indoor pesticides, so they have an important impact on human daily life. The acute toxicity studies of pyrethroid pesticides have gotten many achievements and progress, but there is still no clear demonstration of its long-term chronic effects. This review presented the collection of published experiments, population surveys and laboratory tests on the long-term and chronic effects of pyrethroid pesticides. Typical research papers, and screened out the research progress in neurotoxicity, reproductive developmental toxicity, immunotoxicity and tumor research of pyrethroid pesticides. It can provide reference ideas for further research and development of harmless pesticides and pesticides.

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Influence of perinatal deltamethrin exposure at distinct developmental stages on motor activity, learning and memory

Cited by 9 publications

References 77 publications

Rehmanniae Radix Preparata ameliorates behavioral deficits and hippocampal neurodevelopmental abnormalities in ADHD rat model

Rehmanniae Radix Preparata ameliorates behavioral deficits and hippocampal neurodevelopmental abnormalities in ADHD rat model

Biomarkers of oral subacute toxicity of deltamethrin in exposed male Albino rats

Toxicity and Health Hazards of Pyrethroid Pesticides

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