Influence of perioestrous suprabasal progesterone levels on cycle length, oestrous behaviour and ovulation in heifers

Duchens, M.; Maciel, M.; Gustafsson, H.; Forsberg, M.; Rodriguez‐Martinez, Heriberto; Edqvist, L.‐E.

doi:10.1016/0378-4320(94)01334-i

Cited by 43 publications

(32 citation statements)

References 26 publications

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“…progesterone levels in their milk fat or plasma [10][11][12]. The suprabasal plasma progeste rone concentrations during the follicular phase and the estrous period could originate either from incomplete luteolysis or extragonadal sources such as the pituitary-adrenal axis [11,[13][14][15][16].…”

mentioning

confidence: 99%

Plasma Cortisol and Progesterone Responses to Low Doses of Adrenocorticotropic Hormone in Ovariectmized Lactating Cows

Yoshida

Nakao

2006

Journal of Reproduction and Development

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Abstract. The objective of this study was to describe the responses of the plasma progesterone and cortisol concentrations in ovariectomized lactating cows to low doses of adrenocorticotropic hormone (ACTH). The estrous cycles in 3 lactating cows were synchronized, and the cows were ovariectomized in the luteal phase. ACTH challenge tests were conducted at doses of 3, 6, 12 and 25 IU. Blood samples were collected at 30 min intervals, and the plasma progesterone and cortisol concentrations were analyzed by EIA. A concomitant rise in plasma progesterone and plasma cortisol was observed in cows treated with 12 IU or higher doses of ACTH. Significant increments in the plasma cortisol concentrations were observed at all doses of ACTH. The means (± SE) of the peak plasma progesterone concentrations after the 3, 6, 12 and 25 IU ACTH challenge tests were 0.6 ± 0.1, 1.3 ± 0.4, 1.5 ± 0.3 and 2.4 ± 0.3 ng/ml, respectively. The means of the peak plasma cortisol concentrations in the 3 cows after the ACTH challenge were 14.0 ± 1.5, 17.0 ± 2.5, 23.3 ± 3.0, and 33.3 ± 7.0 ng/ml, respectively. The effects of the doses, time after treatment, and their interaction on the plasma progesterone concentrations after the ACTH challenge were significant (P<0.01). Likewise, the effects of the doses, time after treatment, and their interaction on the plasma cortisol concentrations after the ACTH challenge were significant (P<0.01). The mean AUC values for the plasma progesterone and cortisol concentrations after the ACTH treatments were also significantly affected by the dose of ACTH (P<0.01 and P<0.05, respectively). A significantly positive correlation was obtained between the peak plasma progesterone and cortisol concentrations after different doses of ACTH (r=0.7, P<0.05). The results suggest that lactating dairy cows are capable of secreting a significant amount of adrenal progesterone, reaching up to the minimal concentration necessary to cause suppression of estrus in response to 12 IU ACTH (P<0.01). The concomitant plasma cortisol concentration was 23.3 ng/ml. Key words: Adrenal cortex, Progesterone, Cortisol, Adrenocorticotropic hormone (ACTH), Dairy cows (J. Reprod. Dev. 52: [797][798][799][800][801][802][803] 2006) h i g h h e a t d e t e c t i o n r a t e i s a p r i m a r y require ment for effective reproductive management of dairy herds [1,2]. Recently, the duration of estrus in lactating cows has been reported to be substantially shortened [3][4][5][6], and the percentage of cows exhibiting standing estrus has been decreased [6][7][8][9].Some studies have indicated that cows or heifers with weakened estrous signs show suprabasal

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mentioning

confidence: 99%

Plasma Cortisol and Progesterone Responses to Low Doses of Adrenocorticotropic Hormone in Ovariectmized Lactating Cows

Yoshida

Nakao

2006

Journal of Reproduction and Development

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“…A delayed and diminished post-ovulation progesterone curve has been associated with low conception rates in cattle, and a low progesterone curve has been shown to be related to significantly reduced production of interferon-tau by bovine embryos recovered on Day 16 of pregnancy ( Figure 3). Suprabasal progesterone level around estrus has been described in RBCs (Duchens et al, 1995;Bage et al, 1997;Perez-Marín & España, 2007). It is associated with low gonadotrophin levels and with incomplete luteal regression after luteolysis, which prolongs the follicular growth and damages the oocyte.…”

Section: Hormonal Dysfunctionsmentioning

confidence: 95%

“…A longer estrus-ovulation interval usually appears and premature insemination is then carried out. Duchens et al (1995Duchens et al ( , 1996 have experimentally induced this pathology using retard release progesterone. It has been informed that these levels reduce the number of blastomeres around day 3, accelerate the zygote progress though the oviduct and affect negatively the fertility.…”

Section: Hormonal Dysfunctionsmentioning

confidence: 99%

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Clinical Approach to the Repeat Breeder Cow Syndrome

Marı́n¹,

Moreno²,

Calero³

2012

A Bird's-Eye View of Veterinary Medicine

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“…Another study suggests that high milk production decreases the duration of estrus, probably due to decreased circulating concentrations of estradiol-17β [10]. Suprabasal progesterone concentrations during the periestrous period, which may be caused by incomplete luteolysis and acute stress, could inhibit the expression of estrous behavior [11] and lead to delayed ovulation [12]. Some of these alterations have been reported in association with high milk production of modern dairy cows.…”

mentioning

confidence: 99%

Profiles of Ovarian Steroids, Luteinizing Hormone and Estrous Signs from Luteolysis to Ovulation in Lactating and Non-lactating Dairy Cows

Endo

Nagai

Tanaka

et al. 2012

Journal of Reproduction and Development

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Abstract. The aims of the present study were to investigate the profiles of ovarian steroids and luteinizing hormone (LH) and the appearance of estrous signs in relation to luteolysis and ovulation in lactating and non-lactating cows and to examine the influence of lactation on those observations. Five lactating (daily milk yield of 28.4 ± 3.2 kg; mean ± SD) and five nonlactating cycling Holstein cows were examined. Their ovaries were monitored by ultrasonography daily during one estrous cycle. Blood samples were collected daily and then at 3-h intervals after luteolysis until ovulation. Estrous signs in terms of behavior, the vulva and the vagina were checked at 8-h intervals after luteolysis until ovulation. Profiles of progesterone, estradiol-17β and LH did not differ between the groups. There were no differences in the interval from luteolysis to ovulation (4.6 ± 0.5 and 4.2 ± 0.8 days) and the interval from the estradiol-17β peak to ovulation (34.2 ± 4.5 and 30.6 ± 3.9 h) between lactating and non-lactating cows. The interval from the peak of the LH surge to ovulation was 27 h in all cows examined. Appearance of estrous signs did not differ between the groups. The vaginal estrous signs were observed conspicuously in all cows examined, but the behavioral signs were not observed in 20.0% of the cows. The duration of behavioral signs (41.3 ± 23.6 h) was shorter (P<0.05) than that of the vagina (68.9 ± 25.4 h). These results imply that lactation might not interfere with the hormonal profiles from luteolysis to ovulation.

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Influence of perioestrous suprabasal progesterone levels on cycle length, oestrous behaviour and ovulation in heifers

Cited by 43 publications

References 26 publications

Plasma Cortisol and Progesterone Responses to Low Doses of Adrenocorticotropic Hormone in Ovariectmized Lactating Cows

Plasma Cortisol and Progesterone Responses to Low Doses of Adrenocorticotropic Hormone in Ovariectmized Lactating Cows

Clinical Approach to the Repeat Breeder Cow Syndrome

Profiles of Ovarian Steroids, Luteinizing Hormone and Estrous Signs from Luteolysis to Ovulation in Lactating and Non-lactating Dairy Cows

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