Influence of pH on cephalexin adsorption onto SBA-15 mesoporous silica: Theoretical and experimental study

Removal of cephalexin from artificial wastewater by mesoporous silica materials using Box-Behnken response surface methodology

“…6 and 7; the increasing of adsorbent dose leads to an increase in antibiotic adsorption. This behaviour is also expected as it was early reported [9,36] and also in the research conduct previously [9,36,49] that studied adsorption dyes and organic pollutant onto MCM-41 adsorbent, it was observed that the increase of MCM dosage resulted in increased contaminant removal [1,49]. The percentage of removal usually increases with the increase of adsorbent dosage to a limit of saturation of the adsorbent [1].…”

“…Therefore, at pH 3.00, MCM-41 presents a superficial negative charge that attracts the cephalexin species at 3.0. In a study previously reported [9], the influence of pH on cephalexin adsorption onto SBA-15 mesoporous silica showed that according to the different species of cephalexin in different pH values and pH zpc of adsorbent, the best adsorption efficiency was also obtained at low pH values [9].…”

“…Aliquots of 20.0 mL of 50.0-100.0 mg L -1 of the cephalexin at adjusted pH (3.00-11.0), were introduced in 50.0 mL conical flask containing MCM-41 adsorbent doses (200-800 mg L -1 ) and put in an orbital shaker with temperature control for 30.0-90.0 min. After this time, the samples were taken with clean syringe filters, and the remaining cephalexin antibiotic was spectrophotometrically determined at 258 nm using LUV-100 Spectrophotometer [9]. The percentage of removal of the antibiotic was expressed by the Eq.…”

“…The second way is the human releases from their excretions into domestic sewage considering that the biological treatment of sewage is not complete; the pharmaceuticals can be released into wastewater in metabolised or non-metabolised form. Most of the antibiotics are not biodegradable [7][8][9][10].…”

Carboxymethyl cellulose capsulated layered double hydroxides/drug nanohybrids for Cephalexin oral delivery

“…Cephalexin is a semisynthetic antibiotic derived from cephalosporin and is almost completely absorbed from the gastrointestinal tract, with a bioavailability of 95%. Cephalexin has a half-life of around 1.1 h. To maintain therapeutic range, the drug should be administered 3-4 times a day, which leads to sawtooth kinetics and resulting in ineffective therapy (Legnoverde et al, 2014;Jishnu et al, 2011).…”