Influence of phospholipid-containing additives on the functional condition of organs and systems of mice

Traditional medicine and pharmacology. Achievements, innovations, and alternatives

“…This primarily affects the digestive and protective functions of the stomach and intestines. Therefore, even with minor changes in the chemical composition and physical properties of the diet feed, as well as against the background of the action of conditionally pathogenic microflora of the digestive organs, functional enteropathology develops [3,4,17].…”

Lipid composition of blood plasma and epithelium of the jejunal mucosa in calves with dyspepsia and its correction

“…In particular, dyspepsia in newborn calves is characterized by the development of dyslipidemia (Fomina et al, 2019), which is manifested by an increase in triacylglycerol and cholesterol levels in blood plasma. At the same time, there is an excessive formation of lipid peroxidation products in the blood and cells of the body, which is accompanied by increased permeability of cell membranes, entry of incompletely oxidized metabolites into the peripheral bloodstream, and disorders of cellular energy supply (Gómez & Chamorro, 2017;Gryshchenko et al, 2019Gryshchenko et al, , 2020. Membranopathy, along with the existing dysfunction of the immune system, leads to a decrease in regenerative processes in the tissues of animals recovered from dyspepsia (Gryshchenko et al, 2016;Holstege et al, 2018;Hryschenko et al, 2019).…”

“…The main natural phospholipid source for restoring the lipid structure in cell membranes in the early postnatal period of animal life is colostrum, and later milk (Ellingsen et al, 2016;Gómez & Chamorro, 2017;Lopez & Heinrichs, 2022). Taking into account that phospholipids play not only a structural role, but also stimulate the biological activity of the vast majority of membrane receptors, activate membrane-bound enzymes, regulate numerous metabolic processes between the intra-and intercellular environment, and affect immune responses at the cellular level (Ontsouka et al, 2016;Kim & Wang, 2020), the biologically active additive (BAA) "FLP-MD" with reparative action based on natural phospholipids, the available raw material for which is buttermilk (a by-product of processing the milk into butter), was created (Gryshchenko, 2020;Mohan et al, 2020;Wei et al, 2022). It is important that in their qualitative and quantitative spectrum they correspond to the structure of the plasma membrane, especially epitheliocytes: enterocytes and hepatocytes.…”