Influence of photodynamic therapy in choroidal neovascularization on focal retinal function assessed with the multifocal electroretinogram and perimetry1 1The authors have no proprietary interests in any of the products mentioned in this article.

Chan

Survey of Ophthalmology

et al. 2007

Abstract. Multifocal electroretinography (mfERG) is an investigation that can simultaneously measure multiple electroretinographic responses at different retinal locations by cross-correlation techniques. mfERG therefore allows topographic mapping of retinal function in the central 40--50 of the retina. The strength of mfERG lies in its ability to provide objective assessment of the central retinal function at different retinal areas within a short duration of time. Since the introduction of mfERG in 1992, mfERG has been applied in a large variety of clinical settings. This article reviews the clinical applications of mfERG based on the currently available evidence. mfERG has been found to be useful in the assessment of localized retinal dysfunction caused by various acquired or hereditary retinal disorders. The use of mfERG also enabled clinicians to objectively monitor the treatment outcomes as the changes in visual functions might not be reflected by subjective methods of assessment. By changing the stimulus, recording, and analysis parameters, investigation of specific retinal electrophysiological components can be performed topographically. Further developments and consolidations of these parameters will likely broaden the use of mfERG in the clinical setting.

Section: Photodynamic Therapymentioning

confidence: 99%

Section: Photodynamic Therapymentioning

confidence: 99%

The Clinical Applications of Multifocal Electroretinography: A Systematic Review

Chan

Survey of Ophthalmology

et al. 2007

“…[13][14][15][16][17] Most previous studies have been performed under photopic conditions, which are thought to reflect mainly conemediated photoreceptor and bipolar function. 18,19 Although reduced amplitudes and delayed latency of the cone mfERG have been demonstrated with age [20][21][22] and in different stages of ARM [23][24][25][26] mainly with concentric ring averaging methods, there have been no studies identifying the functional impairment of rods.…”

Section: Introductionmentioning

confidence: 99%

Cone- and rod-mediated multifocal electroretinogram in early age-related maculopathy

Feigl

Brown

Lovie‐Kitchin

et al. 2004

Eye

Purpose To investigate the cone-and rodmediated multifocal electroretinograms (mfERG) in early age-related maculopathy (early ARM). Methods and subjects We investigated the cone-and rod-mediated mfERG in 17 eyes of 17 subjects with early ARM and 16 eyes of 16 age-matched control subjects with normal fundi. All subjects had a visual acuity of 6/12 or better. We divided the ARM subjects into two groups based on drusen size and retinal pigment epithelium abnormalitiesFa less advanced (ARM1) and a more advanced (ARM2) group. The mfERG data were compared to templates derived from the control group. We analysed the mfERG results for the central and peripheral fields (CP method) and the superior and inferior fields (SI method). Results While the mean cone results showed no statistically significant difference between the groups, the rods showed significantly delayed responses in the ARM1 group for the CP and the SI methods, but not in the ARM2 group, although there was a trend of longer latencies compared to the control group. Conclusion Our results show a functional impairment of the rods in early ARM subjects. As there is histopathological evidence showing earlier rod than cone impairment in early ARM, following the rod function with the mfERG might be helpful in diagnosis or for monitoring the progression of early ARM.

“…Various studies have reported the efficacy of the mfERG in the assessment of ARMD [6,19,20,29,33,[39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58].…”

Section: Multifocal Ergmentioning

confidence: 99%

“…Palmowski et al [57] compared retinal function pre-and post-PDT in 16 eyes and found that after PDT the mfERG showed focal improvements in 13 eyes. In 10 eyes, focal retinal function deteriorated in some locations.…”

Section: Multifocal Ergmentioning

confidence: 99%

The electroretinogram: a useful tool for evaluating age-related macular disease?

et al. 2010

With an ageing population, the number of age-related macular disease (ARMD) cases will inevitably rise. This gives greater impetus for the need to identify the disease earlier and assess treatments to slow disease progression. Differing electroretinogram (ERG) modalities have been reviewed in relation to the objective assessment of retinal function in ARMD and for monitoring the effectiveness of clinical interventions. Conflicting results have been found with regard to the efficacy of ERG findings in the investigation of ARMD in previous years. The newer multifocal ERG paradigm provides spatial topographical information about retinal function in ARMD. It has shown promising results in monitoring effectiveness of clinical interventions and studies are continuing in this area. Better knowledge of retinal function in ARMD may lead to enhanced treatments at each phase of the disease.