Influence of photoperiodic history on clock genes and the circadian pacemaker in the rat retina

Rohleder, Nils H.; Langer, Christina; Maus, Christian; Spiwoks-Becker, Isabella; Emser, Angela; Engel, Lydia; Spessert, Rainer

doi:10.1111/j.1460-9568.2005.04528.x

Cited by 17 publications

(14 citation statements)

References 46 publications

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“…The results obtained indicated that the circadian regulation of aanat mRNA is affected by the photoperiodic history (33, 34) thus suggesting that the pacemaker driving aanat transcription in the photoreceptors can store photoperiodic information in a manner similar to that reported for SCN. Another similarity between the SCN clock and the pacemaker driving aanat transcription in the retina has been reported with the respect to the effect of restricted feeding in the rat retina (35).…”

Section: Regulation Of Retinal Melatonin Synthesis By Circadian Clocksmentioning

confidence: 64%

The circadian clock system in the mammalian retina

et al. 2008

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Daily rhythms are a ubiquitous feature of living systems. Generally, these rhythms are not just passive consequences of cyclic fluctuations in the environment, but instead originate within the organism. In mammals, including humans, the master pacemaker controlling 24-hour rhythms is localized in the suprachiasmatic nuclei of the hypothalamus. This circadian clock is responsible for the temporal organization of a wide variety of functions, ranging from sleep and food intake, to physiological measures such as body temperature, heart rate and hormone release. The retinal circadian clock was the first extra-SCN circadian oscillator to be discovered in mammals and several studies have now demonstrated that many of the physiological, cellular, and molecular rhythms that are present within the retina are under the control of a retinal circadian clock, or more likely a network of hierarchically organized circadian clocks that are present within this tissue.

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Section: Regulation Of Retinal Melatonin Synthesis By Circadian Clocksmentioning

confidence: 64%

The circadian clock system in the mammalian retina

et al. 2008

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“…BHLHB3 is a clock gene (19, 20), a transcriptional repressor (18) and importantly a tumor suppressor in lung cancer (21). In D-HEp3 cells BHLHB3 is induced by p38 and was positively linked to genes involved in extracellular matrix biology (e.g., collagen-I α1, MMP2) (Fig1B).…”

Section: Resultsmentioning

confidence: 99%

Computational Identification of a p38SAPK-Regulated Transcription Factor Network Required for Tumor Cell Quiescence

et al. 2009

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The stress-activated kinase p38 plays key roles in tumor suppression and induction of tumor cell dormancy. However, the mechanisms behind these functions remain poorly understood. Using computational tools, we identified a transcription factor (TF) network regulated by p38A/B and required for human squamous carcinoma cell quiescence in vivo. We found that p38 transcriptionally regulates a core network of 46 genes that includes 16 TFs. Activation of p38 induced the expression of the TFs p53 and BHLHB3, while inhibiting c-Jun and FoxM1 expression. Furthermore, induction of p53 by p38 was dependent on c-Jun down-regulation. Accordingly, RNAi down-regulation of BHLHB3 or p53 interrupted tumor cell quiescence, while down-regulation of c-Jun or FoxM1 or overexpression of BHLHB3 in malignant cells mimicked the onset of quiescence. Our results identify components of the regulatory mechanisms driving p38-induced cancer cell quiescence. These may regulate dormancy of residual disease that usually precedes the onset of metastasis in many cancers.

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“…The clock of photoreceptors resembles the central clock in the SCN in being autonomous, capable of storing photoperiodic information (Rohleder et al. 2006), and insensitive to feeding patterns (Oishi et al.…”

Section: Discussionmentioning

confidence: 99%

Unique clockwork in photoreceptor of rat

Schneider

Tippmann

Spiwoks-Becker

et al. 2010

Journal of Neurochemistry

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J. Neurochem. (2010) 115, 585–594. Abstract In mammals, the retina contains a clock system that oscillates independently of the master clock in the suprachiasmatic nucleus and allows the retina to anticipate and to adapt to the sustained daily changes in ambient illumination. Using a combination of laser capture micro‐dissection and quantitative PCR in the present study, the clockwork of mammalian photoreceptors has been recorded. The transcript amounts of the core clock genes Clock, Bmal1, Period1 (Per1), Per3, Cryptochrome2, and Casein kinase Iε in photoreceptors of rat retina have been found to undergo daily changes. Clock and Bmal1 peak with Per1 and Per3 around dark onset, whereas Casein kinase Iε and Cryptochrome2 peak at night. As shown for Clock, Per1, and Casein kinase Iε, the oscillation of transcript amounts results in daily changes of the protein products. The in‐phase oscillation of Clock/Bmal1 with Pers and the rhythmic expression of Casein kinase Iε do not occur in molecular clocks of other tissues including the suprachiasmatic nucleus. Therefore, the findings presented suggest that the photoreceptor clock is unique not only in its position outside the clock hierarchy mastered by the suprachiasmatic nucleus, but also with regard to the intrinsic rhythmic properties of its molecular components.

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Influence of photoperiodic history on clock genes and the circadian pacemaker in the rat retina

Cited by 17 publications

References 46 publications

The circadian clock system in the mammalian retina

The circadian clock system in the mammalian retina

Computational Identification of a p38SAPK-Regulated Transcription Factor Network Required for Tumor Cell Quiescence

Unique clockwork in photoreceptor of rat

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