Influence of physical activity on addiction parameters of rats exposed to amphetamine which were previously supplemented with hydrogenated vegetable fat

Segat, Hecson Jesser; Barcelos, Raquel Cristine Silva; Metz, Vinícia Garzella; Rosa, Higor Zuquetto; Roversi, Katiane; Antoniazzi, Caren Tatiane de David; Vey, Luciana Taschetto; Kronbauer, Maikel; Veit, Juliana Cristina; Piccolo, Jaqueline; Emanuelli, Tatiana; Bürger, Marilise Escobar

doi:10.1016/j.brainresbull.2017.09.013

Cited by 14 publications

(9 citation statements)

References 61 publications

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“…For example, in the studies delivering "Western" style high fat/high sugar diets meant to induce obesity, a variety of dietary fats were used. The fats used to supplement some of the high fat diets included lard [67], fish oil [68], soybean oil [69] while other studies specified the percentage fat in the diet but not the type of fat that was added to achieve this amount [70][71][72]. Because the impact of different fatty acids on health outcomes can be highly different [73], categorizing diets as low or high in fat may result in heterogenous findings as a result of the type of fat delivered.…”

Section: Dietary Patternsmentioning

confidence: 99%

Diet and Anxiety: A Scoping Review

et al. 2021

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Anxiety disorders are the most common group of mental disorders. There is mounting evidence demonstrating the importance of nutrition in the development and progression of mental disorders such as depression; however, less is known about the role of nutrition in anxiety disorders. This scoping review sought to systematically map the existing literature on anxiety disorders and nutrition in order to identify associations between dietary factors and anxiety symptoms or disorder prevalence as well as identify gaps and opportunities for further research. The review followed established methodological approaches for scoping reviews. Due to the large volume of results, an online program (Abstrackr) with artificial intelligence features was used. Studies reporting an association between a dietary constituent and anxiety symptoms or disorders were counted and presented in figures. A total of 55,914 unique results were identified. After a full-text review, 1541 articles met criteria for inclusion. Analysis revealed an association between less anxiety and more fruits and vegetables, omega-3 fatty acids, “healthy” dietary patterns, caloric restriction, breakfast consumption, ketogenic diet, broad-spectrum micronutrient supplementation, zinc, magnesium and selenium, probiotics, and a range of phytochemicals. Analysis revealed an association between higher levels of anxiety and high-fat diet, inadequate tryptophan and dietary protein, high intake of sugar and refined carbohydrates, and “unhealthy” dietary patterns. Results are limited by a large percentage of animal and observational studies. Only 10% of intervention studies involved participants with anxiety disorders, limiting the applicability of the findings. High quality intervention studies involving participants with anxiety disorders are warranted.

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Section: Dietary Patternsmentioning

confidence: 99%

Diet and Anxiety: A Scoping Review

et al. 2021

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“…The proposed mechanism of action for this hypothesis can be seen in Figure 1. The trend of males presenting a greater blockage in drug abuse effects after being exposed to an exercise regimen was found in a few different preclinical 9,10 and clinical trials. 96,97,100 By observing this trend in both preclinical and clinical trials, there is an abundance of evidence supporting the findings of the study by Thanos et al 2 that males who exercised demonstrate a greater attenuation to drugs of abuse than females.…”

Section: The Role Of Testosterone-mediated Exercise Effects On Drug A...mentioning

confidence: 93%

Effects of Exercise on Testosterone and Implications of Drug Abuse: A Review

Perreault¹,

Hammond²,

Thanos

2023

Clin Neuropharm

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Objective: Research points to exercise having a positive effect in fighting relapse and use of drugs of abuse. Through conducting this research, differences have been observed in the effects of exercise on drug abuse between sexes. Many of the studies found that exercise tends to cause a more profound effect in blocking drug relapse or reinstatement in males when compared with females.Methods: Our hypothesis is that these differences in response to drugs of abuse after an exercise regimen could in part be attributed to variations in testosterone levels between males and females.Results: Testosterone has been shown to have a modulatory impact on the dopaminergic activity in the brain, causing an effect on the brain's response to drugs of abuse. Exercise has demonstrated a causal effect on increasing testosterone levels in males, whereas drugs of abuse decrease testosterone levels in males.Conclusions: Thus, exercise raising testosterone levels in males helps to decrease the dopaminergic response in the brain to drugs of abuse causing attenuation to drugs. To find sex-specific exercise treatments for drugs of abuse, it is important to continue researching exercise's efficacy against drugs of abuse.

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“…For this study, d-l-AMPH (Merck®) (4.0 mg/kg/mL) was applied according to previous studies [ 13 , 22 ].…”

Section: Methodsmentioning

confidence: 99%

“…As relapse is a growing concern, our research group has made efforts to search new non-pharmacological adjuvant therapies for drug addiction, especially to prevent relapse. Among them, we can highlight the physical exercise practice [ 13 , 14 ], neonatal tactile stimulation (TS) [ 15 , 16 ], omega-3 supplementation [ 17 ], and AMPH-isotherapic administration [ 18 ], and others.…”

Section: Introductionmentioning

confidence: 99%

Tactile Stimulation in Adult Rats Modulates Dopaminergic Molecular Parameters in the Nucleus accumbens Preventing Amphetamine Relapse

Rossato

Rosa

et al. 2022

Mol Neurobiol

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Amphetamine (AMPH) is a psychostimulant drug frequently related to addiction, which is characterized by functional and molecular changes in the brain reward system, favoring relapse development, and pharmacotherapies have shown low effectiveness. Considering the beneficial influences of tactile stimulation (TS) in different diseases that affect the central nervous system (CNS), here we evaluated if TS applied in adult rats could prevent or minimize the AMPH-relapse behavior also accessing molecular neuroadaptations in the nucleus accumbens (NAc). Following AMPH conditioning in the conditioned place preference (CPP) paradigm, male rats were submitted to TS (15-min session, 3 times a day, for 8 days) during the drug abstinence period, which were re-exposed to the drug in the CPP paradigm for additional 3 days for relapse observation and molecular assessment. Our findings showed that besides AMPH relapse, TS prevented the dopamine transporter (DAT), dopamine 1 receptor (D1R), tyrosine hydroxylase (TH), mu opioid receptor (MOR) increase, and AMPH-induced delta FosB (ΔFosB). Based on these outcomes, we propose TS as a useful tool to treat psychostimulant addiction, which is subsequent to clinical studies; it could be included in detoxification programs together with pharmacotherapies and psychological treatments already conventionally established.

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Influence of physical activity on addiction parameters of rats exposed to amphetamine which were previously supplemented with hydrogenated vegetable fat

Cited by 14 publications

References 61 publications

Diet and Anxiety: A Scoping Review

Diet and Anxiety: A Scoping Review

Effects of Exercise on Testosterone and Implications of Drug Abuse: A Review

Tactile Stimulation in Adult Rats Modulates Dopaminergic Molecular Parameters in the Nucleus accumbens Preventing Amphetamine Relapse

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