Influence of physical factors on tablet splitting, weight and content uniformity of atenolol tablets

Zaid, Abdel Naser; Al-Ramahi, Rowa′; Ghoush, Abeer Abu; Malkieh, Numan; Kharoaf, Maher

doi:10.1007/s40005-012-0030-7

Cited by 6 publications

(2 citation statements)

References 12 publications

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“…The spectrum consisted of rashes, burning, dry hair, hair fall, dandruff, puffy face, eyes infection and ears with itching being the commonest. In a study by Zaid et al, 20.4% of the women reported allergic reactions with itching and redness of the scalp being the commonest and the findings of this study are in line with various other studies done on HDs in the past [ 47 ].…”

Section: Discussionsupporting

confidence: 90%

Ecotoxicity, Health Risks and Contact Allergy Due to p-Phenylenediamine in Hair Dyes and Tattoos: Female Students' Perspectives

Sayed,

Dalai,

Sharma

et al. 2024

Cureus

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While the financial advantages of hair coloring and tattooing are widely acknowledged, environmental hazards and health risks linked to this trend due to their p-phenylenediamine (PPD) content have received less attention. Health education on hair-dying products is warranted to enhance the public's awareness of hair-dying ingredients and their side effects.A cross-sectional study was therefore conducted with 319 students to assess knowledge of ecotoxicity, health risks, and practices of hair dyeing and tattooing among undergraduate students. A random sample of 59 students was checked for any allergic morphology in the scalp and exposed areas of skin near the neck, ears, palms, and nails. Responses collected were used for data analyses using IBM SPSS Statistics for Windows, Version 17 (Released 2008; IBM Corp., Armonk, New York, United States).Use of hair dye was significantly high among study participants 58.5% (n=187; p<0.05). However, their knowledge regarding the presence of PPD in hair dyes and associated environmental toxicity (37.8%, n=121) was very limited. The majority of participants did not do any allergy tests before applying hair dye (88.9%, n=283). The study revealed that the main reason for hair coloring was as a fashion statement (93.7%, n=299). Regarding tattooing practices, 96.9% (n=309) of study participants had never practiced tattoos, and hence, the prevalence of tattooing was 3.9% (n=12). These data confirmed that the practice of hair dyeing as a style statement was high among students. However, the majority were unaware of their PPD contents and their potential ecotoxicity and health risks.

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Section: Discussionsupporting

confidence: 90%

Ecotoxicity, Health Risks and Contact Allergy Due to p-Phenylenediamine in Hair Dyes and Tattoos: Female Students' Perspectives

Sayed,

Dalai,

Sharma

et al. 2024

Cureus

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“…Studies have also reported increased patient adherence due to ease of splitting, as well as cost benefits for the patient when a tablet splitter is used [6,8]. Some studies have found an impact of tablet splitting on the weight and content uniformity of the resulting tablet halves [10,11]. Elderly patients performing splitting may be of particular concern because of their reduced compliance and dexterity, i.e., ability to properly split the tablets [12].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Certain Pharmaceutical Quality Attributes of Lisinopril Split Tablets

et al. 2016

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Tablet splitting is an accepted practice for the administration of drugs for a variety of reasons, including dose adjustment, ease of swallowing and cost savings. The purpose of this study was to evaluate the physical properties of lisinopril tablets as a result of splitting the tablets either by hand or with a splitting device. The impact of the splitting technique of lisinopril (Zestril® tablets, 20 mg) on certain physical parameters such as weight variation, friability, disintegration, dissolution and drug content were studied. Splitting the tablets either by hand or with a splitter resulted in a minute but statistically significant average weight loss of <0.25% of the tablet to the surrounding environment. The variability in the weight of the hand-split tablet halves was more pronounced (37 out of 40 tablet halves varied by more than 10% from the mean weight) than when using the tablet splitter (3 out of 40 tablet halves). The dissolution and drug content of the hand-split tablets were therefore affected because of weight differences. However, the pharmacopoeia requirements for friability and disintegration time were met. Hand splitting of tablets can result in an inaccurate dose and may present clinical safety issues, especially for drugs with a narrow therapeutic window in which large fluctuations in drug concentrations are undesirable. It is recommended to use tablets with the exact desired dose, but if this is not an option, then a tablet splitter could be used.

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Tablet Splitting of Antiepileptic Drugs in Pediatric Epilepsy: Potential Effect on Plasma Drug Concentrations

et al. 2016

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Influence of physical factors on tablet splitting, weight and content uniformity of atenolol tablets

Cited by 6 publications

References 12 publications

Ecotoxicity, Health Risks and Contact Allergy Due to p-Phenylenediamine in Hair Dyes and Tattoos: Female Students' Perspectives

Ecotoxicity, Health Risks and Contact Allergy Due to p-Phenylenediamine in Hair Dyes and Tattoos: Female Students' Perspectives

Evaluation of Certain Pharmaceutical Quality Attributes of Lisinopril Split Tablets

Tablet Splitting of Antiepileptic Drugs in Pediatric Epilepsy: Potential Effect on Plasma Drug Concentrations

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