Influence of pimozide on the locomotor hyperactivity produced by caffeine

Cj, Estler

doi:10.1111/j.2042-7158.1979.tb13453.x

Cited by 20 publications

(5 citation statements)

References 14 publications

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“…Although caf feine-induced activity can be attenuated by neuroleptic treatment at higher doses (see above) [7], caffeine-induced activity is not altered by removal of presynaptic dopamine terminals in the mesolimbic system [10]. However, low-dose (0.5-1.5 mg/kg) amphetamine-induced activity is signifi cantly attenuated by destruction of this dopamine system [10][11][12].…”

Section: Naloxonementioning

confidence: 94%

Effects of Alpha-Flupenthixol and Naloxone on CRF-Induced Locomotor Activation

et al. 1984

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Corticotropin-releasing factor injected intracerebroventricularly in a dose of 1 µg produced a prolonged locomotor activation (3 h) in rats previously habituated to the test cage environment. This activation was reversed by α-flupenthixol (intraperitoneally), a dopamine receptor antagonist, only at cataleptic doses and not at all by naloxone (subcutaneously) in doses of 0.02–5.0 mg/kg. The effective dose 50% (ED₅₀) for the α-flupenthixol reversal of locomotor activity induced by corticotropin-releasing factor was 0.13 mg/kg; similar to the 0.14 mg/kg ED₅₀ needed to reverse the locomotor activation produced by caffeine (10 mg/kg s.c). The ED₅₀ necessary to reverse amphetamine (0.75 mg/kg s.c.) locomotion with this drug was 0.07 mg/kg. The results suggest that the corticotropin-releasing factor acts independently of direct activation of the dopamine or opioid peptide systems.

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Section: Naloxonementioning

confidence: 94%

Effects of Alpha-Flupenthixol and Naloxone on CRF-Induced Locomotor Activation

et al. 1984

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“…Caffeine is generally classified as a general central nervous system stimulant (Ritchie, 1970), though it is widely used for psychomotor stimulant purposes by humans. Caffeine increases locomotor activity in rodents, and this effect is at least partially antagonized by dopamine receptor blockers (Estler, 1979; Waldeck, 1973). Caffeine stimulates mesolimbic dopamine turnover (Govoni et al, 1984).…”

Section: Psychomotor Stimulant Properties Of Addictive Drugsmentioning

confidence: 99%

A psychomotor stimulant theory of addiction.

Wise¹,

Bozarth²

1987

Psychological Review

2,595

1,409

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“…Caffeine injection usually increases locomotor activity (LMA) at reasonable doses (Waldeck 1973;White et al 1978;Estler 1979), an effect that is said to be blocked by pimozide, a DA receptor antagonist (Waldeck 1973;Estler 1979). This finding would tend to suggest that caffeine increases, not decreases, DA release.…”

Section: Catecholaminesmentioning

confidence: 99%