Influence of Piperine on the Pharmacokinetics of Nevirapine under Fasting Conditions

Abstract

This pilot study provided evidence for enhanced bioavailability of nevirapine when administered with piperine. Further in-depth studies in a large number of patients receiving different dosage regimens are required to confirm these results and further our understanding of a possible clinical advantage arising from the bioenhancement capabilities of piperine in the treatment of HIV infection.

Bioavailability enhancers of herbal origin: An overview

“…Blood samples were collected post-dose. The results of the study showed that there was an enhanced bioavailability of nevirapine when administered with piperine [123] .…”

Cancer prevention and therapy through the modulation of the tumor microenvironment

“…Additionally, the in vitro absorption rate of piperine is relatively high compared with other natural products like curcumin without any metabolic modification of piperine during the absorption process [393]. Piperine is widely used as a bioavailability enhancer for a diverse group of therapeutic agents including the antimicrobial agent rifampicin [394], nevirapine which is a potent inhibitor of human immunodeficiency virus (HIV)-1 reverse transcriptase [395] and curcumin which has anticancer properties [396]. Piperine has various biological effects including antioxidant activity [397] anti-inflammatory effect by inhibiting PMA-induced COX-2 [398].…”

A facile and rapid method for the black pepper leaf mediated green synthesis of silver nanoparticles and the antimicrobial study

“…It also contains small amounts of safrole (C 10 H 10 O 2 ), pinene (C 10 H 16 ), sabinene (C 10 H 16 ), limonene (C 10 H 16 ), caryophyllene (C 15 H 24 ) and Linalool (C 10 H 18 O) compound. The fruits have variety of activities including CNS depressant, antipyretic, analgesic, hepatoprotective (Lee et al 1984), bioavailability enhancer Kasibhatta and Naidu 2007), antioxidant (Khajuria et al 1997) and anti-inflammatory (Majumdar et al 1990). …”