Influence of plasma GSH level on acute radiation mucositis of the oral cavity

Bhattathiri, V.N.; Sreelekha, T.T.; Stolzmann, Paul; Remani, P.; Chandini, R; Vijayakumar, T.; Mk, Nair

doi:10.1016/0360-3016(94)90294-1

Cited by 20 publications

(14 citation statements)

References 16 publications

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“…The level of glutathione has been shown to influence the acute radiation effect in animals and humans [12,23]. We did not find a statistically significant difference in the dynamics of GSH or GSSG changes.…”

Section: Analysis Of the Anti-oxidant Activities In Rbc Of The Patiencontrasting

confidence: 68%

High superoxide dismutase and low glutathione peroxidase activities in red blood cells predict susceptibility of lung cancer patients to radiation pneumonitis

Park

Ramnath

Yang

et al. 2007

Free Radical Biology and Medicine

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Radiation pneumonitis is an unpredictable complication of radiotherapy for lung cancer and a condition which can cause significant morbidity. The ability to identify patients at a high risk of developing pneumonitis is critical, since it will enable the individualization of the treatment plan. Because the cytotoxic effect of radiation is propagated through ROS and ROS-driven oxidative stress, the role of anti-oxidant defense systems in radiation pneumonitis was investigated. Using the pneumonitis-sensitive C3H/HeN mice as a model, we demonstrated that the anti-oxidant response of the lung correlated well with that of RBC. We then proceeded to test whether differences of RBC anti-oxidant response would predict the pneumonitis development in patients. SOD, GPX, CAT activities and glutathione in RBC were measured at baseline and then weekly for 6 weeks of treatment in fifteen eligible patients receiving concurrent chemo-radiotherapy for unresectable stage III NSCLC. Striking differences were found in the anti-oxidant activities of RBC with respect to the pneumonitis development. Those who developed pneumonitis showed higher SOD and lower GPX activities at baseline compared to those who did not (3.7 vs. 6.8 unit/mg for median SOD, 16.5 vs. 10.7 nmol/min/mg for median GPX). The functional imbalance of SOD and GPX was displayed consistently throughout the treatment period. The sensitivity and specificity of pneumonitis prediction were further increased when the GPX/SOD ratio was analyzed (pre-treatment P = 0.0046). Our results provide a strong rationale to monitor SOD and GPX activities of RBC to identify patients who are at risk of developing pneumonitis, and to implement a strategy of increasing the GPX/SOD ratio in order to lower the risk.

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Section: Analysis Of the Anti-oxidant Activities In Rbc Of The Patiencontrasting

confidence: 68%

High superoxide dismutase and low glutathione peroxidase activities in red blood cells predict susceptibility of lung cancer patients to radiation pneumonitis

Park

Ramnath

Yang

et al. 2007

Free Radical Biology and Medicine

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“…Intrinsic factors such as DNA aneuploidy, S-phase fraction and proliferation kinetics, tumor vascularity and hypoxia and glutathione content are believed to influence radiation resistance of a tumor. [3][4][5] Clinical assessment, details will be discussed in Materials and Methods section, is the only routinely practiced procedure to evaluate the tumor response to the treatment. The degree of tumor shrinkage is commonly used index of radioresponsiveness.…”

Section: Introductionmentioning

confidence: 99%

Prediction of radiotherapy response in cervix cancer by Raman spectroscopy: A pilot study

et al. 2008

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Radiotherapy is the choice of treatment for locally advanced stages of the cervical cancers, one of the leading female cancers. Because of intrinsic factors, tumors of same clinical stage and histological type often exhibit differential radioresponse. Radiotherapy regimen, from first fraction of treatment to clinical evaluation of response, spans more than 4 months. Clinical assessment by degree of tumor shrinkage is the only routinely practiced method to evaluate the tumor response. Hence, a need is created for development new methodologies that can predict the tumor response to radiotherapy at an early stage of the treatment which can lead to tailor-made protocols. To explore the feasibility of prediction of tumor radioresponse, Raman spectra of cervix cancer tissues that were collected before (malignant) and 24 h after patient was treated with 2nd fraction of radiotherapy (RT) were recorded. Data were analyzed by Principal Components Analysis (PCA) and results were correlated with clinical evaluation of radioresponse. Mean Raman spectra of RT tissues corresponding to different levels of tumor response, complete, partial, and no response, showed minute but significant variations. The unsupervised PCA of malignant tissues failed to provide any classification whereas RT spectra gave clear classification between responding (complete and partial response) and nonresponding conditions as well as a tendency of separation among responding conditions. These results were corroborated by supervised classification, by means of discrimination parameters: Mahalanobis distance and spectral residuals. Thus, findings of the study suggest the feasibility of Raman spectroscopic prediction of tumor radioresponse in cervical cancers.

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“…In a randomized trail, Kigawa et al (35) demonstrated that mean GSH content of NR was significantly higher than responders in ovarian cancers. Further, the importance of plasma GSH content as a predictive parameter for individual sensitivity to radiation-induced acute mucositis in oral cavity has been reported (4). A study conducted by Jadhav et al (6) with limited study participants (45 subjects) of pre-and postradiotherapy demonstrated a good correlation between the extent of GSH depletion and the tumor response (CR, PR, and NR) both in plasma and tumor tissue.…”

Section: Discussionmentioning

confidence: 94%

“…The differential radioresponse has been attributed to intrinsic factors such as DNA aneuploidy, S-phase fraction and proliferation kinetics, tumor vascularity-related hypoxia and intracellular low-molecular-weight thiol, and glutathione (GSH) (4). Cellular redox status is balanced by thiol-to-disulfide status of reduced (GSH) and oxidized form (GSSG) of glutathione.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Predictive and Prognostic Significance of Glutathione Levels and DNA Damage in Cervix Cancer Patients Undergoing Radiotherapy

Vidyasagar

Kodali

Saxena

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

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Influence of plasma GSH level on acute radiation mucositis of the oral cavity

Cited by 20 publications

References 16 publications

High superoxide dismutase and low glutathione peroxidase activities in red blood cells predict susceptibility of lung cancer patients to radiation pneumonitis

High superoxide dismutase and low glutathione peroxidase activities in red blood cells predict susceptibility of lung cancer patients to radiation pneumonitis

Prediction of radiotherapy response in cervix cancer by Raman spectroscopy: A pilot study

Predictive and Prognostic Significance of Glutathione Levels and DNA Damage in Cervix Cancer Patients Undergoing Radiotherapy

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