Influence of polymer architecture on the structure of complexes formed by PEG–tertiary amine methacrylate copolymers and phosphorothioate oligonucleotide

The use of PEGylated poly [2-(N,N-dimethylamino) ethyl methacrylate] as a mucosal DNA delivery vector and the activation of innate immunity and improvement of HIV-1-specific immune responses

“…Polyethylene glycol (PEG) is one of the most widely used biocompatible polymers in drug delivery systems [22]. PEGylation of cationic polymers used for gene delivery in order to reduce cytotoxicity have been investigated [23][24][25][26][27] because of the prominent characteristics of PEG such as biocompatibility, watersolubility, charge shielding effect which can reduce nonspecific interaction between polyplexes and blood component, etc. [28].…”

Soluble complexes in aqueous mixtures of low charge density comb polyelectrolyte and oppositely charged surfactant probed by scattering and NMR

“…Among the family of polymers, poly(ethylene oxide), PEO, has received considerable interest due to its useful properties, including the decreased water solubility at elevated temperatures bility at high ionic strength, prolonged blood circulation times, and low toxicity, which makes them attractive in drug and gene delivery systems [11,13,14,19].…”

Characterization of Polyion Complex Micelles Designed to Address the Challenges of Oligonucleotide Delivery

“…Comparison of Fig. 2A (31). The effect of the cationic block length on ODN incorporation was also studied by preparing micelles at the N/P ratio of 1.75 with polymers of the PEG 68 -b-PAEMA series (Fig.…”

“…These two aspects are exploited herein to prepare a 33-member block copolymer library in which the chain length and buffering capacity of the polymers are methodically varied. To the best of our knowledge, there is only one other study dealing with the optimization of PICMs of a phosphorothioate ODN and an AEMA derivative (31). Specifically, Desphande et al looked at the effects of the architecture (linear, brush or comb) of copolymers of PEG and 2-(N,N-dimethylamino)ethyl methacrylate (DMAEMA) on ODN complexation.…”