Influence of Polyuronides on Biological Oxidation, Liver Antitoxic Functions, and Erythrocyte Membrane Condition in Lead-Intoxicated Rats

Kaisheva, N. Sh.; Vasilenko, Yu. K.; Kaishev, A. Sh.

doi:10.1007/s11094-017-1504-8

Cited by 3 publications

(2 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, according to the indicator "total number of fungi", all types of vinasse do not meet the pharmacopoeic requirements, significantly exceeding the norm even with significant dilution. The reason for fungi is clear: for the intensification of alcohol fermentation in the technological production of alcohol, the use of various races of alcohol yeast is implied, which are not only not pathogenic, but also produce a large amount of protein, vitamins [1,29,30]. Thus, according to the indicator "microbiological purity", waste obtained after vinasse processing is safe even in terms of pharmacopoeia requirements.…”

Section: Intestine Evacuation Functionmentioning

confidence: 99%

Processing of after-alcohol vinasse for environmentally friendly environment

Kaishev

Kaisheva

Larsky

et al. 2022

IOP Conf. Ser.: Earth Environ. Sci.

View full text Add to dashboard Cite

One of the industrial sources of intoxication polluting the environment is vinasse – a secondary raw material formed during the alcoholic processing of grain in 12 times the volume of alcohol produced. Due to the low content of dry substances (up to 8%), low shelf life (up to 2 days), seasonality of consumption in livestock, the transportation, especially the liquid phase of vinasse, is not economically profitable, which causes the need for its disposal or processing and determines the relevance of this study. Based on the chemical composition of vinasse, the purpose of the study is to study the possibility of obtaining pectins from it as biologically active compounds, which would reduce the volume of vinasse released into the environment thus ensuring its protection. The purpose of the study was fulfilled by solving the following tasks: development of a method of pectins release from vinasse, assessment of their physicochemical and biological properties, determination of chemical and microbiological safety of vinasse wastes. The study included technological, physicochemical, chemical, biological methods. Vinasse fractions were obtained according to the developed method of vinasse processing based on vortex extraction, concentration of extractions, alcohol release of the end products, pectins from liquid (yield 3.1%) and solid (yield 2.9%), which ensured a 20-fold reduction in the volume of vinasse. The characteristics of pectins were established: authenticity, loss in mass during drying, pH, molar mass, content of pectic acid, functional groups, binding properties. The safety and gastroprotective activity of pectins was established. Mother solutions after the release of pectins were estimated to be less than 3.9 times the chemical consumption of oxygen and satisfactory microbiological purity, which made it possible to evaluate them as safe industrial waste.

show abstract

Section: Intestine Evacuation Functionmentioning

confidence: 99%

Processing of after-alcohol vinasse for environmentally friendly environment

Kaishev

Kaisheva

Larsky

et al. 2022

IOP Conf. Ser.: Earth Environ. Sci.

View full text Add to dashboard Cite

show abstract

“…From the mere synthesis of proteins, to the detoxification of waste, liver does all of this and more 1 . The liver is also active in drug absorption and detoxification and its undesirable compounds that can be hepatotoxic [2][3] .…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective role of Azadirachta Indica and Vitamin E in acetaminophen induced liver toxicity in Wistar rats

Hameed¹,

Khan²,

Imran³

et al. 2021

PJMHS

View full text Add to dashboard Cite

Aim To study the comparative effect of acetaminophen with aqueous Neem leaf extract (Azadirachta Indica) and vitamin E mediated liver toxicity on the basis of liver enzymes. Methods: A total of sixty (60) Wistar rats of either sex were divided equally into four groups. Each groupwas made up of 15 animals. Group A was the control group. Animals in Group B were treated with a single oral dose of 2 mg / kg b / w Paracetamol. Group C animals with 500 mg / kg b / w oral Neem extract for 15 days with oral administration of 2 mg / kg b / w oral Paracetamol. In Group D, animals received the same dose of Paracetamol and 100 mg / kg b / w intra-peritoneal vitamin E for 15 days, respectively. The liver enzymes ALT,AST, and ALP were then evaluated. Data was analyzed using SPSS Version 20.0 with level of significance being kept at p-value ≤0.05 Results: In the 4 groups, The ALT values were 22.8 (Group A), 100 (Group B), 29.11 (Group C), and 31.16 U/L (Group D). The AST values were 25 (Group A), 40 (Group B), 20 (Group C), and 15 (Group D) U/L. The ALP values were 220 (Group A), 445 (Group B), 242 (Group C), and 244 (Group D) U/L. There was significant increase in liver enzymes were found in Group B after induction of Paracetamol toxicity, however, hepatoprotective effects could be seen in the intervention Group C and D Conclusion: Azadirachta Indica and Vitamin E showed hepatoprotective effects on the Wistar rats that were subjected to Paracetamol Key words: Azadirachta Indicaleaf extract, Vitamin E, Paracetamol, Wistar rats

show abstract