Influence of Polyvinyl Alcohol (PVA) on PVA-Poly-N-hydroxyethyl-aspartamide (PVA-PHEA) Microcrystalline Solid Dispersion Films

Abstract

This study was conducted to formulate buccal films consisting of polyvinyl alcohol (PVA) and poly-N-hydroxyethyl-aspartamide (PHEA), to improve the dissolution of the drug through the oral mucosa. Ibuprofen sodium salt was used as a model drug, and the buccal film was expected to enhance its dissolution rate. Two different concentrations of PVA (5% w/v and 7.5% w/v) were used. Solvent casting was used to prepare films, where a solution consisting of drug and polymer was cast and allowed to dry. Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM) were used to investigate the properties of films. In vitro dissolution studies were also conducted to investigate drug release. SEM studies showed that films containing a higher concentration of PVA had larger particles in microrange. FTIR studies confirmed the presence of the drug in films and indicated that ibuprofen sodium did not react with polymers. DSC studies confirmed the crystalline form of ibuprofen sodium when incorporated within films. In vitro dissolution studies found that the dissolution percentage of ibuprofen sodium alone was increased when incorporated within the film from 59 to 74%. This study led to the development of solid microcrystalline dispersion as a buccal film with a faster dissolution rate than the drug alone overcoming problem of poor solubility.

Preparation, Characterization and Pharmacokinetics of Tolfenamic Acid-Loaded Solid Lipid Nanoparticles

“…C-O stretching vibration absorption peaks appear at 1099 cm −1 [32]. The surfactant PVA has a C=O stretching vibration absorption peak at 1732 cm −1 , and that at 2940 cm −1 is an asymmetric C-H stretching vibration absorption peak [33]. The characteristics of the TA active pharmaceutical ingredient (API) are as follows: the peak at 1267 cm −1 is -CH deformation, 1500 cm −1 is an -NH bending vibration, 1661 cm −1 is a C=O stretching vibration absorption peak, and 3340 cm −1 is the -NH stretching vibration peak [34][35][36]; these peaks were observed in the TA-SLN sample.…”

Nanoclay-Based Composite Films for Transdermal Drug Delivery: Development, Characterization, and in silico Modeling and Simulation

“…A rapid drug release from the formulations was observed due to the presence of hydrophilic polymer prepared without HNTs. 48 The formulations (F3 and F4) containing drug and HNTs in the same amount (1:1) showed about 60% drug release in 8 h (480 min). The nanocomposite films (F5 and F6) containing drug and HNTs in a ratio of 2:1 showed about 80% drug release in the first 4 h (240 min).…”

Gallic Acid-Loaded Sodium Alginate-Based (Polyvinyl Alcohol-Co-Acrylic Acid) Hydrogel Membranes for Cutaneous Wound Healing: Synthesis and Characterization

“…In PVA, OH stretching was observed at 3285 cm −1 and C=O vibrations appeared at 1708 cm −1 [ 25 ]. Asymmetric stretching of C–H group appeared at 2907 cm −1 [ 26 ]. The absorption band near 3000 cm −1 indicates the presence of hydroxyl groups in the acrylic acid, the peak at 1693 cm −1 is caused by C=O stretching, and the band at 1634 cm −1 represents the C=C stretching [ 27 ].…”