2014
DOI: 10.1097/eja.0000000000000081
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Influence of polyvinyl chloride infusion extension tube on propofol injection pain

Abstract: BACKGROUNDPropofol injection pain is a common and unsolved anaesthesia problem.OBJECTIVESThe present study attempted to confirm that the plasticiser di(2-ethylhexyl) phthalate in polyvinyl chloride (PVC) infusion tubes may increase propofol injection pain by increasing the aqueous propofol concentration.DESIGNA randomised controlled study.SETTINGUniversity teaching hospital, 1 April to 25 June 2013.PATIENTSOne hundred patients scheduled for elective surgery were allocated randomly to the PVC or the control (C)… Show more

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Cited by 4 publications
(2 citation statements)
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“…Propofol was first administered through a 1-m-long extension tube before reaching the body; in other studies, a Y-type direct injection catheter has been used. Specifically, a study by Wu et al (29) examining the extension tube's influence in propofol injection-related pain reported that extending the length of the propofol tube increases the concentration of di-(2-ethylhexyl) phthalate in the patient's body, as well as the free propofol concentration, thereby increasing propofol injection-related pain (29).…”
Section: Discussionmentioning
confidence: 99%
“…Propofol was first administered through a 1-m-long extension tube before reaching the body; in other studies, a Y-type direct injection catheter has been used. Specifically, a study by Wu et al (29) examining the extension tube's influence in propofol injection-related pain reported that extending the length of the propofol tube increases the concentration of di-(2-ethylhexyl) phthalate in the patient's body, as well as the free propofol concentration, thereby increasing propofol injection-related pain (29).…”
Section: Discussionmentioning
confidence: 99%
“…Some patients recall the induction of anesthesia as the most painful part of the perioperative period 32 . It has been reported that pain from injection is ranked third among the 33 most common anesthesia problems in outpatient procedures 33 . The exact mechanism of pain on injection is not known.…”
Section: New Innovations In Drug Developmentmentioning
confidence: 99%