Influence of polyvinylpyrrolidone on the interaction between water and methanol

Guettari, Moez; Gomati, R.

doi:10.1590/s0104-66322013000300024

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…This was well reflected by the smaller value of Flory‐Huggins interaction parameter calculated for PVP‐water (2.08) as compared to PSf‐water (2.36), which indicates better interaction between PVP and water. PVP and water interact well due to the formation of large numbers of hydrogen bond between them . This greatly assisted in stabilizing the casting dope.…”

Section: Resultsmentioning

confidence: 99%

“…As aforementioned, kinetics aspect played a more important role in governing the phase inversion when varying PSf/PVP ratio. Owing to lower casting dope viscosity at PSf/PVP ratio of 0.833 and excellent interaction between PVP and water, PVP assisted the diffusion of water into the dope solution. This ensured high water influx that promoted rapid phase separation .…”

Section: Resultsmentioning

confidence: 99%

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Thermodynamics and kinetics control of support layer synthesis for enhanced thin film composite membrane performance

Beh

Sum

et al. 2017

J of Applied Polymer Sci

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The desalination performance of a thin film composite (TFC) membrane hinges highly on the surface characteristics of support membrane. In this study, good wettability, regular pore size, and moderate roughness were identified as the critical surface properties of support membrane in forming a defect-free, uniform, and structurally stable polyamide film. These features were tailored by adjusting the thermodynamics and kinetics properties of the polymer solution via polysulfone (PSf)/polyvinylpyrrolidone (PVP) ratio as well as using N,N-dimethylacetamide (DMAc) and N,N-dimethylformamide as co-solvent. It was found that the membrane formation was controlled kinetically by altering the PSf/PVP ratio but thermodynamically by using co-solvent. The TFC membrane with better desalination performance was achieved with the support membrane prepared at PSf/PVP ratio of 0.941 without any co-solvent. The resulting TFC membrane attained the highest permeability ratio of 0.691 bar 21 for water/NaCl filtration in this study.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Thermodynamics and kinetics control of support layer synthesis for enhanced thin film composite membrane performance

Beh

Sum

et al. 2017

J of Applied Polymer Sci

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Unlocking the sorption mechanism of perfluoroalkyl acids (PFAAs) on geosynthetics: Case of the geotextile components of geosynthetic clay liners

Mikhael,

Bouazza,

Gates

et al. 2024

Geotextiles and Geomembranes

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Effect of Solvents, Stabilizers and the Concentration of Stabilizers on the Physical Properties of Poly(d,l-lactide-co-glycolide) Nanoparticles: Encapsulation, In Vitro Release of Indomethacin and Cytotoxicity against HepG2-Cell

et al. 2022

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A biocompatible, biodegradable and FDA-approved polymer [Poly lactic-co-glycolic acid (PLGA)] was used to prepare the nanoparticles (NPs) to observe the effect of solvents, stabilizers and their concentrations on the physical properties of the PLGA-NPs, following the encapsulation and in vitro release of Indomethacin (IND). PLGA-NPs were prepared by the single-emulsion solvent evaporation technique using dichloromethane (DCM)/chloroform as the organic phase with Polyvinyl-alcohol (PVA)/Polyvinylpyrrolidone (PVP) as stabilizers to encapsulate IND. The effects of different proportions of PVA/PVP with DCM/chloroform on the physiochemical properties (particle size, the polydispersity index, the zeta potential by Malvern Zetasizer and morphology by SEM) of the NPs were investigated. DSC was used to check the physical state, the possible complexation of PLGA with stabilizer(s) and the crystallinity of the encapsulated drug. Stabilizers at all concentrations produced spherical, regular-shaped, smooth-surfaced discrete NPs. Average size of 273.2–563.9 nm was obtained when PVA (stabilizer) with DCM, whereas it ranged from 317.6 to 588.1 nm with chloroform. The particle size was 273.2–563.9 nm when PVP was the stabilizer with DCM, while it was 381.4–466.6 nm with chloroform. The zeta potentials of PVA-stabilized NPs were low and negative (−0.62 mV) while they were comparatively higher and positive for PVP-stabilized NPs (+17.73 mV). Finally, drug-loaded optimal NPs were composed of PLGA (40 mg) and IND (4 mg) in 1 mL DCM/chloroform with PVA/PVP (1–3%), which resulted in sufficient encapsulation (54.94–74.86%) and drug loading (4.99–6.81%). No endothermic peak of PVA/PVP appeared in the optimized formulation, which indicated the amorphous state of IND in the core of the PLGA-NPs. The in vitro release study indicated a sustained release of IND (32.83–52.16%) from the PLGA-NPs till 72 h and primarily followed the Higuchi matrix release kinetics followed by Korsmeyer–Peppas models. The cell proliferation assay clearly established that the organic solvents used to prepare PLGA-NPs had evaporated. The PLGA-NPs did not show any particular toxicity in the HepG2 cells within the dose range of IND (250–500 µg/mL) and at an equivalent concentration of PLGA-NPs (3571.4–7142.7 µg/mL). The cytotoxicity of the hepatotoxic drug (IND) was reduced by its encapsulation into PLGA-NPs. The outcomes of this investigation could be implemented to prepare PLGA-NPs of acceptable properties for the encapsulation of low/high molecular weight drugs. It would be useful for further in vitro and in vivo applications to use this delivery system.

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Influence of polyvinylpyrrolidone on the interaction between water and methanol

Cited by 3 publications

References 20 publications

Thermodynamics and kinetics control of support layer synthesis for enhanced thin film composite membrane performance

Thermodynamics and kinetics control of support layer synthesis for enhanced thin film composite membrane performance

Unlocking the sorption mechanism of perfluoroalkyl acids (PFAAs) on geosynthetics: Case of the geotextile components of geosynthetic clay liners

Effect of Solvents, Stabilizers and the Concentration of Stabilizers on the Physical Properties of Poly(d,l-lactide-co-glycolide) Nanoparticles: Encapsulation, In Vitro Release of Indomethacin and Cytotoxicity against HepG2-Cell

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