Influence of pore water velocity on the release of carbofuran and fenamiphos from commercial granulates embedded in a porous matrix

Paradelo, Marcos; Pérez‐Rodríguez, Paula; Arias‐Estévez, Manuel; López-Periago, J. Eugenio

doi:10.1016/j.jconhyd.2012.10.004

Cited by 7 publications

(2 citation statements)

References 21 publications

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“…In a modification of this approach, a lipase-lipid-drug system was employed to provide sustained drug release where the matrix erosion was due to the lipolytic action of lipase on the substrate. Incorporation of lipaseactivity accelerators such as calcium carbonate or glyceryl monostearate provides flexibility for controlling drug release [16,[32][33][34].…”

Section: The Embedded Matrix Principlementioning

confidence: 99%

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Design of Sustained Action Dosage Forms; Mini-Review

Abdellatif¹

2018

Pharm Anal Acta

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Greatest idealized per-oral sustained action products have been formulated in the form of oral dosage forms such as capsules or tablets. The characteristic trouble of preparing sustained action liquids has controlled the availability of such dosage forms. Encapsulated long-acting dosage forms have two particular benefits over capsules and tablet designs. Firstly, the inability to be disintegrated which may persist in the stomach for long periods of time, extremely suspending in the stomach and retard the absorption of maintenance dose. Secondly, the disintegration of the capsule shell in the gastric fluid releases particles that pass across the pyloric valve. Also, the release of drug by a meaningful fraction of the granules is highly possible. If a tablet fails to release drug, the entire maintenance dose is lost. This review discusses the different methods for enhancing the sustained drug action. cancer cells, such as the SSTRs, the folate receptor, and transferrin receptors. Moreover, nanoparticles coated cell-penetrating peptides and protein-transduction domains, such as oligoarginine and TAT facilitated the uptake of these nanoparticles which cannot successfully enter cancer cells [8]. This review discusses the different methods for enhancing the sustained drug action, the barrier principle, model based on diffusion, and model based on dissolution. Moreover, the review discusses the principle release from the matrix.

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Section: The Embedded Matrix Principlementioning

confidence: 99%

“…The embedded matrix principle has also been applied to prepare sustained release encapsulations [32][33][34]. Medicaments are dispersed in molten lipid materials to form a slurry which may be spray congealed, or granulated after solidification.…”

Section: The Embedded Matrix Principlementioning

confidence: 99%