Influence of Positron Emitters on Standard  -Camera Imaging

Jødal, Lars; Afzelius, Pia; Jensen, Svend Borup

doi:10.2967/jnmt.113.131003

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…The 6:1 ratio appears to saturate the detector. This could be because the activity of the PET isotope is too high, and it is increasing the dead time in the SPECT detector or even flooding the camera [24]. In our experiment, no bleed through of 511 keV downscattered photons was observed in SPECT images.…”

Section: Resultsmentioning

confidence: 68%

[18F]-Fluorinated Carboplatin and [111In]-Liposome for Image-Guided Drug Delivery

Lamichhane

Dewkar

Sundaresan

et al. 2017

IJMS

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Radiolabeled liposomes have been employed as diagnostic tools to monitor in vivo distribution of liposomes in real-time, which helps in optimizing the therapeutic efficacy of the liposomal drug delivery. This work utilizes the platform of [111In]-Liposome as a drug delivery vehicle, encapsulating a novel 18F-labeled carboplatin drug derivative ([18F]-FCP) as a dual-molecular imaging tool as both a radiolabeled drug and radiolabeled carrier. The approach has the potential for clinical translation in individual patients using a dual modal approach of clinically-relevant radionuclides of 18F positron emission tomography (PET) and 111In single photon emission computed tomography (SPECT). [111In]-Liposome was synthesized and evaluated in vivo by biodistribution and SPECT imaging. The [18F]-FCP encapsulated [111In]-Liposome nano-construct was investigated, in vivo, using an optimized dual-tracer PET and SPECT imaging in a nude mouse. The biodistribution data and SPECT imaging showed spleen and liver uptake of [111In]-Liposome and the subsequent clearance of activity with time. Dual-modality imaging of [18F]-FCP encapsulated [111In]-Liposome showed significant uptake in liver and spleen in both PET and SPECT images. Qualitative analysis of SPECT images and quantitative analysis of PET images showed the same pattern of activity during the imaging period and demonstrated the feasibility of dual-tracer imaging of a single dual-labeled nano-construct.

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Section: Resultsmentioning

confidence: 68%

[18F]-Fluorinated Carboplatin and [111In]-Liposome for Image-Guided Drug Delivery

Lamichhane

Dewkar

Sundaresan

et al. 2017

IJMS

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show abstract

“…However, a slow biological uptake mechanism may force a protocol where a long-lived tracer is applied early in the study. In addition, if the study involves both PET and SPECT, it can be advantageous to perform SPECT imaging before injecting the PET tracer because SPECT can be sensitive to relatively small amounts of PET tracer [7], whereas PET imaging is insensitive to SPECT tracers (unless very high activities of high-energy SPECT tracers are involved [8]) because PET detection is based on coincident detections and most SPECT tracers involve only noncoincident photons.…”

Section: Introductionmentioning

confidence: 99%