Influence of Post-Transplant Immunosuppressive Therapy on Gastrointestinal Transit Using Biomagnetic Method: A Pilot Study

Teixeira, Mauro; Américo, Madileine Francely; Oliveira, Ricardo Brandt de; Miranda, José Ricardo de Arruda; Romeiro, Fernando Gomes; Corá, Luciana Aparecida

doi:10.1007/s10620-014-3335-8

Cited by 5 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The following parameters were calculated by applying statistical moment (24) : mean gastric emptying time (MGET), which represents the amount of magnetic material that empties from the stomach as a function of time t (min); mean colon arrival time (MCAT), which indicates the amount of magnetic material reaching the proximal colon region as a function of time t (min), and mean intestinal transit time (MSITT), which is the difference between MCAT and MGET (19) .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Gastrointestinal Motility in Elderly Patients With Well-Controlled Type 2 Diabetes Mellitus

Sena

SILVA

Américo

et al. 2022

Arq. Gastroenterol.

View full text Add to dashboard Cite

Background: Gastrointestinal (GI) motility disorders in type 2 diabetes mellitus (T2DM) are common. However, the endpoints in well-controlled T2DM in elderly patients are barely understood. Objective: To evaluate GI transit and gastric myoelectric activity in elderly patients with T2DM who were undergoing treatment with metformin and to compare them with non-diabetic healthy controls. Methods: A total of thirty participants were enrolled in this study: young non-diabetic (n=10), elderly non-diabetic controls (n=10), and patients with T2DM managed with metformin (n=10). After fasting overnight, the participants ingested a standard meal and magnetic markers for non-invasive monitoring of GI transit and gastric contractility using the alternating current biosusceptometry and electrogastrography techniques. Results: Mean gastric emptying time, mean colon arrival time, and mean intestinal transit time were determined. There were no significant differences between the groups and in the parameters evaluated (P>0.05). The frequency and amplitude of gastric myoelectric activity were not different between groups; however, abnormal rhythmic index and the half-bandwidth were slightly higher for both elderly diabetic and non-diabetic groups compared with the young adults (P<0.01 and P<0.05, respectively). Conclusion: Our study showed unaltered gastric emptying and intestinal transit in T2DM patients with good glycemic control, and suggest changes in the gastric electrical activity can be a part of aging.

show abstract

Section: Discussionmentioning

confidence: 99%

“…GI transit time of the ingested magnetic markers was evaluated on a single-day study, following a protocol developed by our research group (19,22) . After fasting overnight, all participants had their capillary blood glucose measured with a portable blood glucose meter (ACCU -CHEK Active, Roche, Brazil).…”

Section: Study Protocolmentioning

confidence: 99%

Gastrointestinal Motility in Elderly Patients With Well-Controlled Type 2 Diabetes Mellitus

Sena

SILVA

Américo

et al. 2022

Arq. Gastroenterol.

View full text Add to dashboard Cite

show abstract

“…Teixeira et al . () demonstrated in humans that TAC in triple immunosuppressive therapy (TAC + AZA + PRED) was able to accelerate gastric emptying and caecum arrival compared with control and CSA + AZA + PRED treatment.…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal disorders after immunosuppression: an experimental model to evaluate the influence of monotherapy on motility parameters

Dall'Agnol

Corá

Teixeira

et al. 2017

Experimental Physiology

View full text Add to dashboard Cite

What is the central question of this study? The aim was to propose an animal model for investigating the effects of immunosuppressive monotherapy on gastrointestinal motility using a non-invasive biomagnetic technique. What is main finding and its importance? In our experimental study, immunosuppressive drugs currently in use accelerated gastric emptying whilst increasing the frequency and amplitude of gastric contractions after treatment, except for Mycophenolate and azathioprine. Alternating current biosusceptometry is a useful tool to evaluate side-effects of drugs on the gastrointestinal tract, which will help in understanding the symptoms and improving clinical management of patients. The aim was to propose an animal model for investigating the effects of immunosuppressive monotherapy on gastrointestinal motility using a non-invasive biomagnetic technique. Male Wistar rats were randomly distributed into the following treatment groups: ciclosporin, tacrolimus, prednisone, sirolimus, mycophenolate mofetil, everolimus, azathioprine and control. Each animal was treated for 14 days by gavage with dosages ranging from 1 to 20 mg kg day considering the area-to-volume ratio and hepatic metabolism. Gastrointestinal transit and gastric contractility measurements were evaluated by alternating current biosusceptometry before and after treatment. Gastric emptying was faster in animals treated with tacrolimus, prednisone, sirolimus and everolimus compared with control animals (126.7 ± 12.7 min). There was a significant increase in the frequency of contractions after ciclosporin, tacrolimus, azathioprine and sirolimus treatment compared with control animals (4.6 ± 0.3 cycles min ). Increases in the amplitude of contraction were observed after treatment with tacrolimus, sirolimus and everolimus compared with control rats (34.9 ± 6.0 dB). The results showed that our animal model was suitable for demonstrating that most immunosuppressive drugs currently in use impaired at least one gastrointestinal motility parameter. As a non-invasive technique, alternating current biosusceptometry is a potentially useful tool for evaluation of side-effects of drugs in gastrointestinal tract, helping us to understand the symptoms to improve clinical management of patients.

show abstract

“…Regarding transit time, gastric emptying time (as measured with magnetic markers after a standardised meal using Alternating Current Biosusceptometry) was decreased in patients treated with tacrolimus after kidney transplant (47 ± 34 min) compared to healthy subjects (176 ± 42 min) or patients treated with cyclosporine A (195 ± 42 min) …”

Section: Medicines Used To Treat Gastrointestinal Diseases and Their mentioning

confidence: 99%

Effects of medicines used to treat gastrointestinal diseases on the pharmacokinetics of coadministered drugs: a PEARRL Review

Litou

Effinger

Kostewicz

et al. 2019

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

Objectives Drugs used to treat gastrointestinal diseases (GI drugs) are widely used either as prescription or over-the-counter (OTC) medications and belong to both the 10 most prescribed and 10 most sold OTC medications worldwide. The objective of this review article is to discuss the most frequent interactions between GI and other drugs, including identification of the mechanisms behind these interactions, where possible.Key findings Current clinical practice shows that in many cases, these drugs are administered concomitantly with other drug products. Due to their metabolic properties and mechanisms of action, the drugs used to treat gastrointestinal diseases can change the pharmacokinetics of some coadministered drugs. In certain cases, these interactions can lead to failure of treatment or to the occurrence of serious adverse events. The mechanism of interaction depends highly on drug properties and differs among therapeutic categories. Understanding these interactions is essential to providing recommendations for optimal drug therapy. Summary Interactions with GI drugs are numerous and can be highly significant clinically in some cases. While alterations in bioavailability due to changes in solubility, dissolution rate, GI transit and metabolic interactions can be (for the most part) easily identified, interactions that are mediated through other mechanisms, such as permeability or microbiota, are less well-understood. Future work should focus on characterising these aspects.

show abstract

Influence of Post-Transplant Immunosuppressive Therapy on Gastrointestinal Transit Using Biomagnetic Method: A Pilot Study

Cited by 5 publications

References 23 publications

Gastrointestinal Motility in Elderly Patients With Well-Controlled Type 2 Diabetes Mellitus

Gastrointestinal Motility in Elderly Patients With Well-Controlled Type 2 Diabetes Mellitus

Gastrointestinal disorders after immunosuppression: an experimental model to evaluate the influence of monotherapy on motility parameters

Effects of medicines used to treat gastrointestinal diseases on the pharmacokinetics of coadministered drugs: a PEARRL Review

Contact Info

Product

Resources

About