Influence of postoperative enteral nutrition on cellular immunity. A random double-blinded placebo controlled clinical trial

Beier-Holgersen, Randi; Brandstrup, Birgitte

doi:10.1007/s00384-011-1335-0

Cited by 16 publications

(7 citation statements)

References 14 publications

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“…In contrast to our results, Beier et al found a significant reduction in the number of NK cells up to 7 d after primary colorectal surgery. However, an important difference between our study and Beier's is that the preoperative percentage of NK cells was much lower in our patients [33]. This significantly lower percentage of NK cells in our liver resection patients might be related to their more advanced disease (metastatic colon cancer).…”

Section: Discussioncontrasting

confidence: 72%

Innate immune function after breast, lung, and colorectal cancer surgery

Ramirez¹,

Ai²,

Bauer³

et al. 2015

Journal of Surgical Research

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Section: Discussioncontrasting

confidence: 72%

Innate immune function after breast, lung, and colorectal cancer surgery

Ramirez¹,

Ai²,

Bauer³

et al. 2015

Journal of Surgical Research

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“…A recent study verified that partial EN support during perioperation will not only improve the postoperative nutritional status and immune function, but also moderate the inflammatory response of gastric cancer patients after operative trauma [ 11 ]. Beier-Holgersen et al [ 12 ] proved early postoperative enteral nutrition had an important influence on immediate unspecific cellular immunity and had an activating effect on specific cellular immunity. In our current randomized and controlled study, we provided EN with postoperative patients in the FTS group on POD1 and in the conventional group on POD2.…”

Section: Discussionmentioning

confidence: 99%

Fast-track surgery improves postoperative clinical recovery and cellular and humoral immunity after esophagectomy for esophageal cancer

et al. 2016

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BackgroundOur aim was to investigate the influence of FTS on human cellular and humoral immunity using a randomized controlled clinical study in esophageal cancer patients.MethodsBetween October 2013 and December 2014, 276 patients with esophageal cancer in our department were enrolled in the study. The patients were randomized into two groups: FTS pathway group and conventional pathway group. The postoperative hospital stay, hospitalization expenditure, and postoperative complications were recorded. The markers of inflammatory and immune function were measured before operation as well as on the 1st, 3rd, and 7th postoperative days (POD), including serum level of interleukin-6 (IL-6), C-reactive protein (CRP), serum globulin, immunoglobulin G (IgG), immunoglobulin M (IgM), immunoglobulin A (IgA) and lymphocyte subpopulations (CD3 lymphocytes, CD4 lymphocytes, CD8 lymphocytes and the CD4/CD8 ratio) in the patients between the two groups.ResultsIn all, 260 patients completed the study: 128 in the FTS group and 132 in the conventional group. We found implementation of FTS pathway decreases postoperative length of stay and hospital charges (P < 0.05). In addition, inflammatory reactions, based on IL-6 and CRP levels, were less intense following FTS pathway compared to conventional pathway on POD1 and POD3 (P < 0.05). On POD1 and POD3, the levels of IgG, IgA, CD3 lymphocytes, CD4 lymphocytes and the CD4/CD8 ratio in FTS group were significantly higher than those in control group (All P < 0.05). However, there were no differences in the level of IgM and CD8 lymphocytes between the two groups.ConclusionsFTS improves postoperative clinical recovery and effectively inhibited release of inflammatory factors via the immune system after esophagectomy for esophageal cancer.Trial registrationChiCTR-TRC-13003562, the date of registration: August 29, 2013.

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“…Based on these findings, posttransplant management can be altered and individualized. One of the most promising approaches would be nutritional intervention . Nutritional status and management may alter mechanistic as well as absolute number of lymphocytes and affect host immunity .…”

Section: Discussionmentioning

confidence: 99%

Peritransplant absolute lymphocyte count as a predictive factor for advanced recurrence of hepatitis C after liver transplantation

et al. 2013

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Lymphocytes play an active role in natural immunity against hepatitis C virus (HCV). We hypothesized that a lower absolute lymphocyte count (ALC) may alter HCV outcome after liver transplantation (LT). The aim of this study was to investigate the impact of peritransplant ALC on HCV recurrence following LT. A total of 289 LT patients between 2005 and 2011 were evaluated. Peritransplant ALC (pre‐LT, 2‐week, and 1‐month post‐LT) and immunosuppression were analyzed along with recipient and donor factors in order to determine risk factors for HCV recurrence based on METAVIR fibrosis score. When stratifying patients according to pre‐ and post‐LT ALC (<500/μL versus 500‐1,000/μL versus >1,000/μL), lymphopenia was significantly associated with higher rates of HCV recurrence with fibrosis (F2‐4). Multivariate Cox regression analysis showed posttransplant ALC at 1 month remained an independent predictive factor for recurrence (P = 0.02, hazard ratio [HR] = 2.47 for <500/μL). When peritransplant ALC was persistently low (<500/μL pre‐LT, 2‐week, and 1‐month post‐LT), patients were at significant risk of developing early advanced fibrosis secondary to HCV recurrence (F3‐4 within 2 years) (P = 0.02, HR = 3.16). Furthermore, severe pretransplant lymphopenia (<500/μL) was an independent prognostic factor for overall survival (P = 0.01, HR = 3.01). The use of rabbit anti‐thymocyte globulin induction (RATG) had a remarkable protective effect on HCV recurrence (P = 0.02, HR = 0.6) despite its potential to induce lymphopenia. Subgroup analysis indicated that negative effects of posttransplant lymphopenia at 1 month (<1,000/μL) were significant regardless of RATG use and the protective effects of RATG were independent of posttransplant lymphopenia. Conclusion: Peritransplant ALC is a novel and useful surrogate marker for prediction of HCV recurrence and patient survival. Immunosuppression protocols and peritransplant management should be scrutinized depending on peritransplant ALC. (Hepatology 2014;58:35–45)

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Influence of postoperative enteral nutrition on cellular immunity. A random double-blinded placebo controlled clinical trial

Abstract: Early postoperative enteral nutrition has an important influence on the immediate unspecific cellular immunity and an activating effect on the specific cellular immunity compared to "no food".

Cited by 16 publications

References 14 publications

Innate immune function after breast, lung, and colorectal cancer surgery

Innate immune function after breast, lung, and colorectal cancer surgery

Fast-track surgery improves postoperative clinical recovery and cellular and humoral immunity after esophagectomy for esophageal cancer

Peritransplant absolute lymphocyte count as a predictive factor for advanced recurrence of hepatitis C after liver transplantation

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