Influence of prenatal maternal stress on umbilical cord blood cytokine levels

Andersson, Niklas; Li, Qian; Mills, Carrie W.; Ly, Jenny; Nomura, Yoko; Chen, Jia

doi:10.1016/j.reprotox.2015.07.059

Cited by 8 publications

(9 citation statements)

References 20 publications

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“…It is possible that in cases where pregnant women suffer not only from AD but also from depression or psychosomatic disorders, the offspring have a significantly higher risk of developing AD up to the age of 18-20 years. [27][28][29][30][31][32][33][34] Possible psycho-immunological pathways are changes in cytokine levels 21 or oxidative stress transferred by the placenta. 35 Psychosocial job strain in general and alcohol intake during pregnancy in particular 36,37 are significant risk factors for AD development in offspring, with alcohol intake being the most prominent risk factor.…”

Section: Factors That May Explain Change In Atopic Dermatitis Severitmentioning

confidence: 99%

European task force on atopic dermatitis position paper: treatment of parental atopic dermatitis during preconception, pregnancy and lactation period

Vestergaard

Wollenberg

Barbarot

et al. 2019

Acad Dermatol Venereol

173

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Atopic dermatitis (AD) is a common inflammatory skin disease that affects both children and adults, including a large number of adults of reproductive age. Several guidelines for the treatment of AD exist, yet specific recommendations for the treatment of pregnant or lactating women and for adults planning to have a child are often lacking. This position paper from the European Task force on Atopic Dermatitis (ETFAD) is based on up‐to‐date scientific literature on treating pregnant and lactating women as wells as adults with AD planning to have a child. It is based on the expert opinions of members of the ETFAD and on existing safety data on the proposed treatments, many of which are derived from patients with other inflammatory diseases or from transplantation medicine. For treating future parents, as well as pregnant and lactating women with AD, the use of topical treatments including moisturizers, topical corticosteroids, tacrolimus, antiseptics such as chlorhexidine, octenidine, potassium permanganate and sodium hypochlorite (bleach) is deemed to be safe. Ultraviolet (UV) therapy may also be used. Systemic treatment should be prescribed only after careful consideration. According to the opinion of the ETFAD, treatment should be restricted to systemic corticosteroids and cyclosporine A, and, in selected cases, azathioprine.

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Section: Factors That May Explain Change In Atopic Dermatitis Severitmentioning

confidence: 99%

European task force on atopic dermatitis position paper: treatment of parental atopic dermatitis during preconception, pregnancy and lactation period

Vestergaard

Wollenberg

Barbarot

et al. 2019

Acad Dermatol Venereol

173

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“…In humans, maternal immune activation is associated with increased serum levels of pro-inflammatory cytokines (Andersson et al, 2016; Coussons-Read, Okun, & Nettles, 2007). Higher levels of inflammatory makers, such as C-reactive protein (CRP) at birth (cord blood), a sensitive marker of low-grade chronic inflammation, can signpost a range of obstetric risks including amniotic fluid infection (Yoon et al, 2000), neonatal sepsis (Joram et al, 2006), and predict neurologic impairment in preterm infants (Kaukola et al, 2006).…”

Section: Prenatal Adversity Inflammation and Cognitive Functionmentioning

confidence: 99%

Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence

et al. 2018

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In 785 mother-child (50% male) pairs from a longitudinal epidemiological birth cohort, we investigated associations between inflammation-related epigenetic polygenic risk scores (i-ePGS), environmental exposures, cognitive function, and child and adolescent internalizing and externalizing problems. We examined prenatal and postnatal effects. For externalizing problems, one prenatal effect was found: i-ePGS at birth associated with higher externalizing problems (ages 7-15) indirectly through lower cognitive function (age 7). For internalizing problems, we identified two effects. For a prenatal effect, i-ePGS at birth associated with higher internalizing symptoms via continuity in i-ePGS at age 7. For a postnatal effect, higher postnatal adversity exposure (birth through age 7) associated with higher internalizing problems (ages 7-15) via higher i-ePGS (age 7). Hence, externalizing problems were related mainly to prenatal effects involving lower cognitive function, whereas internalizing problems appeared related to both prenatal and postnatal effects. The present study supports a link between i-ePGS and child and adolescent mental health.

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“…Several studies have shown that PMPS is linked to a change in the cytokine profile of offspring to one that is predominately of the Th2 type, 25‐29 suggesting that the effects of stress in utero may programme the immune system in a way that predisposes to asthma.…”

Section: The Association Between Prenatal Maternal Psychological Strementioning

confidence: 99%

“…The results were statistically significant for most of the cytokines measured. Three of the papers 27‐29 found a significant link between PMPS and increased IL‐4 (a Th2 cytokine) in offspring whilst two papers found a significant link to decreased IFN‐y (Th1 cytokine). Significant positive associations to other Th2 cytokines (IL‐1b,6,8,10,13) were also seen (Table 2).…”

Section: The Association Between Prenatal Maternal Psychological Strementioning

confidence: 99%

“…Andersson et al (2016b) 29 found that different stressors affected different cytokines. This may be because depending on the type of stressor, the physiological response may vary, for example changes in cortisol and catecholamine levels may not be the same, and this may affect cytokines differently.…”

Section: The Association Between Prenatal Maternal Psychological Strementioning

confidence: 99%

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Consequences of maternal psychological stress during pregnancy for the risk of asthma in the offspring

Al-Hussainy

Mohammed

2020

Scand J Immunol

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The British Lung Foundation reports that over 12% of the UK population-eight million people-have been diagnosed with asthma during their lifetime, and that there are 160 000 new cases a year. 1 Symptoms vary from occasional mild breathlessness through to frequent debilitating bouts of severe breathing problems. One of the most accepted mechanisms of asthma pathogenesis implicates the actions of cytokines produced by T-helper 2 (Th2) cells, but the cause of asthma remains unknown. Known risk factors for the development of asthma include genetic predisposition, reduced gastrointestinal flora biodiversity in infancy, early-life exposure to cigarette smoke, allergens and reduced exposure to respiratory infections. Recently, there has been growing interest in its developmental origins. Stressors on maternal physiology during pregnancy can lead to long-lasting effects in offspring in a process known as developmental programming. Prenatal maternal psychological

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Influence of prenatal maternal stress on umbilical cord blood cytokine levels

Cited by 8 publications

References 20 publications

European task force on atopic dermatitis position paper: treatment of parental atopic dermatitis during preconception, pregnancy and lactation period

European task force on atopic dermatitis position paper: treatment of parental atopic dermatitis during preconception, pregnancy and lactation period

Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence

Consequences of maternal psychological stress during pregnancy for the risk of asthma in the offspring

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