Influence of prenatal maternal stress on the immunocompetence of the offspring

Sobrian, Sonya K.; Vaughn, V.T.; Bloch, Earl F.; Burton, Laureen E.

doi:10.1016/0091-3057(92)90189-m

Cited by 42 publications

(43 citation statements)

References 66 publications

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“…Also consistent with previous findings, prenatal stress did not alter litter size (Anderson et al, 1986;Beckhardt & Ward, 1983;Peters, 1982;Sobrian et al, 1992;Szuran et al, 1991;Wilke et al, 1982), ma1e:female ratios (Sobrian et al, 19921, anogenital distance (Ward 1974, 1977, or male and female littermate weights prior to weaning (Beckhardt & Ward, 1983;Fride, Dan, Gavish, & Weinstock, 1985;Peters, 1986;Sobrian et al, 1992). Although body weights were similar prior to weaning, at 30 days of age prenatally stressed offspring weighed more than controls.…”

Section: Discussionsupporting

confidence: 91%

Prenatal stress alters immune function in the offspring of rats

Klein

Rager

1995

Developmental Psychobiology

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Pregnant rats were either exposed to restraint under bright lights for 45 min three times daily (n = 7) or were left undisturbed (n = 8) during Days 14-21 of gestation. Offspring were tested for cellular immune responses as measured by Concanavalin A-stimulated proliferation and Natural Killer (NK) cytotoxicity of splenocytes as juveniles or adults, or were tested for specific humoral immune responses to in vivo challenge with the antigen Keyhole Limpet Hemocyanin (KLH) as adults. Results indicated that: (a) Proliferation did not vary as a function of sex or prenatal treatment in either juvenile or adult offspring; (b) in juveniles NK cytotoxicity was marginally lower in males as compared to females, and was also marginally reduced by prenatal stress in males but not females, whereas in adults, NK cytotoxicity was marginally enhanced by prenatal stress in both sexes; and (c) prenatally stressed offspring of both sexes had higher levels of anti-KLH antibodies as compared to controls.

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Section: Discussionsupporting

confidence: 91%

Prenatal stress alters immune function in the offspring of rats

Klein

Rager

1995

Developmental Psychobiology

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“…Previous research involving prenatal manipulation and immune function in the offspring has focused on the effects of environmental toxins, dietary alterations and various pharmaceuticals (Silva et al 1968, Roberts & Chapman 1981, Schmidt 1984. Daily handling, anxiety, electric foot-shocks, restraint with or without bright lights and elevated temperatures, noise, crowding and other stressor stimuli applied to dams can cause these changes in their adult offspring (Ader & Plaut 1968, Fride & Weinstock 1984, 1989, Harvey & Chevins 1985, Sobrian 1988, VonSaal et al 1991, Sobrian et al 1992, Klein & Rager 1995, Silva & Palermo-Neto 1999, Williams et al 1999a. In contrast, power frequency alternating magnetic fields had no effect on reproduction and prenatal development of mice (Yasuyuki et al 2002).…”

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confidence: 99%

Role of TNF-α in prenatal alterations in dams of mice under thermal stress

et al. 2006

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The possible involvement of cytokines such as tumour necrosis factor-a (TNF-a), interleukin-1b (IL-1b) and interferon-g (IFN-g) that are suspected of causing pregnancy loss and miscarriage has been investigated in dams of mice subjected to hyperthermia. Thermal stress was induced by exposing mice dams at 40721C for 4 h every day during the different phases of the gestation period whereas the normothermic animals were housed at 22721C. The effect of maternal thermal stress was measured in pregnant mice at different phases of the gestation period namely, blastogenesis-implantation phase (days 0-5 postconceptionem [p.c.]), organogenesis or embryogenesis phase (days 6-15 p.c.) and fetogenesis phase (days 16-20 p.c.). Uterine examination of dams subjected to hyperthermia on days 6-15 p.c. showed maximum reduction in live fetus number, gestational index and maximum pre-and postimplantation loss in comparison with dams housed in normothermic environment and dams exposed to thermal stress between days 0-5 and 16-20 p.c. Maximum resorption rate and number of non-viable fetuses were observed in dams exposed to hyperthermia during days 6-15 p.c. Elevated levels of TNF-a and IL-1b were observed in the amniotic fluid of dams subjected to hyperthermia during days 6-15 p.c. but IFN-g levels remained unaltered. Single intraperitoneal (i.p.) administration of recombinant mouse TNF-a at a dose of 1 and 0.5 ng/ mice in dams on day 6 in normothermic condition resulted in a reduced number of live fetuses. Administration of anti-TNF-a antibody i.p. at a dose of 10 mg/dam on day 6 p.c. and subjected to thermal stress between days 6-15 p.c. increased marginally the number of fetuses but failed to attain statistical significance in comparison with days 6-15 p.c. thermally stressed dams without antibody treatment. It is concluded that the induction of TNF-a, in the amniotic fluid is associated with thermal stress during pregnancy and may be linked to the reproductive performances of dams. This study will help in understanding the mechanism of thermal injury in pregnant subjects.

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“…Studies in rodents and monkeys showed that postnatal stress induced by maternal separation or frequent handling affects many aspects of blood cellular immunity, in juveniles as well as in adults, such as T-cell numbers (Lubach, Coe, & Ershler, 1995), lymphocyte proliferation response to mitogen (Ackerman et al, 1988;Lubach, Coe, Ershler, & Klopp, 1989;Neveu, Deleplanque, Puglisi Allegra, D'Amato, & Cabib, 1994), and natural killer cell cytotoxicity (Coe et al, 1989;Neveu et al, 1994). Furthermore, prenatal stressors have been shown to in¯uence immunological competence (Kay, Tarcic, Poltyrev, & Weinstock, 1998;Pronin et al, 1997;Sobrian, Vaughn, Bloch, & Burton, 1992). Although these animal studies clearly demonstrate that stressors acting during pregnancy and lactation have long-lasting effects on the immune system, nonsocial disturbances of natural mother±infant interactions were usually investigated.…”

Section: Introductionmentioning

confidence: 97%

Social rearing conditions before weaning influence numbers and proportions of blood immune cells in laboratory rats

Stefanski

2001

Developmental Psychobiology

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The influence of the early social rearing environment on blood cellular immunity was investigated in the male offspring of Long-Evans rats. Sons of females housed in pair groups (P-males) and sons of females living in a mixed sex colony (C-males) were studied. After weaning at the age of 21 days, offspring were housed individually to ensure identical experiences until the age of 100 days when immunological assessments were conducted. C-males had significantly higher numbers of blood CD4 and CD8 T cells as well as higher numbers of granulocytes and monocytes than P-males. In contrast, the number of B cells and NK cells was similar in P- and C-males. T-cell responsiveness to ConA, determined in the peripheral blood mononuclear cells and whole blood assays, did not differ significantly between the two groups. The study indicates that the early social environment affects numbers and proportions of many blood immune cell subsets in later life.

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Influence of prenatal maternal stress on the immunocompetence of the offspring

Cited by 42 publications

References 66 publications

Prenatal stress alters immune function in the offspring of rats

Prenatal stress alters immune function in the offspring of rats

Role of TNF-α in prenatal alterations in dams of mice under thermal stress

Social rearing conditions before weaning influence numbers and proportions of blood immune cells in laboratory rats

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