Influence of pretransplant dialysis modality on the change of lymphocyte subset populations and acute rejection rates after renal transplantation

Satoh, Shigeru; Tsuchiya, Norihiko; Sato, Kazunari; Oda, Hiroshi; Komatsuda, Atsushi; Habuchi, Tomonori; Kato, Takumi

doi:10.1111/j.1442-2042.2004.00915.x

Cited by 6 publications

(5 citation statements)

References 22 publications

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“…Studies among renal transplant recipients, suggested a different immune profile according to patients' previous dialysis modalities, specifically more sustained inflammation and lymphocyte activation/exhaustion in HD compared to CAPD patients. 27,28 Those results come to agreement with our own findings concerning the higher frequency of CD4CD28null and CD8CD28null cells in HD compared to CAPD patients. Although it would be very interesting to search for the possible beneficial effect of kidney transplantation in these T-cell subtypes and the IRP of CKD patients, little is known, as there are no prospective studies focused on the estimation of these parameters.…”

Section: Discussionsupporting

confidence: 90%

“…Hence, the arising question of whether peritoneal dialysis could possibly have a potential benefit comparing to HD, regarding cardiovascular risk and chronic inflammation, although premature, yet exists and seeks for an answer. Studies among renal transplant recipients, suggested a different immune profile according to patients' previous dialysis modalities, specifically more sustained inflammation and lymphocyte activation/exhaustion in HD compared to CAPD patients 27,28 . Those results come to agreement with our own findings concerning the higher frequency of CD4CD28null and CD8CD28null cells in HD compared to CAPD patients.…”

Section: Discussionsupporting

confidence: 89%

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Influence of end stage renal disease on CD28 expression and T‐cell immunity

et al. 2020

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Background T‐cell immunity is affected in end stage renal disease (ESRD). However, whether this happens at pre‐ or post‐dialysis stage and what is the impact of different renal replacement methods, remains unclear. We investigated the alterations of T‐cell subtypes in patients at pre‐dialysis ESRD and their further changes during dialysis. Methods CD4+, CD8+, CD4 + CD28null and CD8 + CD28null T‐cells were analysed in 40 ESRD patients at two different time points, (a) the day started on dialysis (ESRD‐T0) and (b) 6 months later (ESRD‐T6), while being on haemodialysis (HD) or continuous ambulatory peritoneal dialysis (CAPD). Twenty‐five age matched healthy volunteers served as controls. Results CD4+ and CD8+ T‐cells were significantly reduced in ESRD‐T0 patients compared to controls, 604 (105‐3551) vs 943 (584‐1867)μ/L, P = .001, and 352 (103‐1561) vs 422.4 (263‐1453)μ/L, P = .05, respectively. However, proportions of CD4 + CD28null and CD8 + CD28null cells were significantly increased, 6.4 (0.3‐30)% vs 2.7 (0.1‐7.8)%, P = .04 and 58.2 (12.8‐85.4)% vs 39 (7.8‐57.1)%, P = .01, respectively. Proportion of CD4 + CD28null cells showed significant correlation with serum CRP (r = .4, P = .04) and albumin levels (r = −.5, P = .007) in ERSD patients. ESRD‐T0 patients with cardiovascular disease (CVD) had increased CD4 + CD28null and CD8 + CD28null proportions, 8.6 (1‐30)% vs 2.1 (0.1‐19.8)%, P = .04 and 62.5 (12.8‐85.4)% vs 45.5 (5.7‐73.7)%, P = .02, respectively, compared to those without. Six months later, both CD4 + CD28null and CD8 + CD28null T‐cells were increased in HD compared to CAPD patients, by +110.11 (−27.1 to 311.4)% vs −28.1 (−100 to 30)%, P = .003 and +55.23 (−29.06 to 197.93)% vs −8.34 (−54.99 to 66.72)%, P = .05, respectively. Conclusions CD4 + CD28null and CD8 + CD28null T‐cells are increased at pre‐dialysis ESRD, and correlate with chronic inflammatory markers and the presence of CVD. Dialysis methods seem to have different impact on these subpopulations.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

Influence of end stage renal disease on CD28 expression and T‐cell immunity

et al. 2020

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“…On the other hand, some reported the opposite conclusion 2. A difference in the immune status between HD and PD patients was also reported by many authors 6–8. Recently, the acute rejection rate has been found to be very low, being estimated to be 14% in this institution (data not shown), with the administration of the standard 4 immunosuppressive drugs; tacrolimus or cyclosporine, mycophenolate mofetil, basiliximab, and steroids.…”

Section: Discussionmentioning

confidence: 51%

Short‐term outcome of renal transplantation treated with pre‐transplant peritoneal dialysis

Kitada

Doi

Nishiki

et al. 2010

Dialysis & Transplantation

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OBJECTIVE Pre‐transplant dialysis has been reported to have an impact on the outcome in renal transplantation; however, it is still controversial. This study evaluated the short‐term outcome of pre‐transplant peritoneal dialysis (PD) in comparison to that of hemodialysis (HD). PATIENTS AND METHODS All living donor kidney transplantations performed from January 2008 to April 2009 were enrolled and divided into 2 groups according to pre‐transplant dialysis, HD and PD. The recipient's age, duration of dialysis, acute rejection episodes, incidence of infection, serum creatinine level, and surgical complications were evaluated. RESULTS The PD group was significantly younger and the duration of their dialysis was shorter. The creatinine level in the PD group was significantly lower than that in the HD group. Acute rejection proven by biopsy was seen in 4 of 36 patients in the HD group and in only 1 of 14 patients in the PD group. There was no difference in the incidence of infection between the 2 groups. There were no vessel complications in any patients, but there were a few urological complications in both groups. Delayed graft function resulting from intractable ascites occurred in 1 patient in the PD group. CONCLUSION Renal transplantation in patients with pre‐transplant PD can be performed safely, although the development of ascites, the timing of removal of the PD catheter, and encapsulating peritoneal sclerosis may occur even after successful transplantation.

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“…The type of dialysis is known to have a range of effects on the immune response (19). Mild monocytosis and lymphopenia are more prevalent in patients receiving HD compared with those in PD, and these could be responsible for the higher rate of acute rejection episodes in the early stages following renal transplantation in patients in HD (20). Moreover, patients in HD are more prone to infections and to an inadequate response to vaccinations (21), and severe lymphopenia has been shown to be a predictor of mortality in these patients (19).…”

Section: Discussionmentioning

confidence: 99%

Effect of Type of Dialysis on CMV-Specific CD8+ T Cells in Kidney Transplant Candidates

Vidal-Castiñeira¹,

Corte-Iglesias²,

Sobrino-Díaz

et al. 2019

Front. Immunol.

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Background: Dialysis is the first procedure to partially replace renal function in end-stage renal diseases, despite several adverse side effects, such as infections. The primary aim of this study was to evaluate the levels of immune CMV-specific CD8+ T cells in a representative cohort of pre-transplant patients receiving hemodialysis (HD) or peritoneal dialysis (PD). The secondary aim was to monitor the CMV-specific CD8+ T cells in kidney transplant recipients undergoing different types of dialysis during the first year following their transplant. Methods: Sixty-nine patients were enrolled and examined with respect to the type of dialysis they received. HLA class I dextramers for CMV were used to determine the quantity of CMV-specific CD8+ T cells. The CMV DNA viral load was also determined. Forty-two of the patients enrolled in the study underwent solid organ transplantation and were analyzed during their first year post-transplantation. Results: Patients receiving HD had fewer CMV-specific CD8+ T cells than those in PD ( p < 0.05). We also observed that patients in PD had more CMV-specific CD8+ T cells during the follow-up period than those in HD ( p < 0.05), independently of the CMV DNA. Finally, PD patients had a higher frequency of CD8+ Effector-Memory RA T cells (TEMRA) and a lower frequency of central memory T cells (TCM) than did HD patients. Conclusions: These results indicate the better status of CMV-specific T cell immunity in PD patients. The use of CMV T cell dextramers would be advantageous for monitoring the CD8+ T-specific response, enabling the use of prophylactic treatment to be optimized.

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Influence of pretransplant dialysis modality on the change of lymphocyte subset populations and acute rejection rates after renal transplantation

Cited by 6 publications

References 22 publications

Influence of end stage renal disease on CD28 expression and T‐cell immunity

Influence of end stage renal disease on CD28 expression and T‐cell immunity

Short‐term outcome of renal transplantation treated with pre‐transplant peritoneal dialysis

Effect of Type of Dialysis on CMV-Specific CD8+ T Cells in Kidney Transplant Candidates

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