Influence of previous or synchronous bladder cancer on oncologic outcomes after radical nephroureterectomy for upper urinary tract urothelial carcinoma

Pignot, G.; Colin, P.; Zerbib, Marc; Audenet, François; Soulié, M.; Hurel, S.; Delage, F.; Irani, Jacques; Descazeaud, A.; Droupy, S.; Rozet, François; Phé, Véronique; Ruffion, A.; Long, Jean-Alexandre; Crouzet, Sébastien; Houlgatte, A.; Bigot, Pierre; Guy, Laurent; Faïs, Pierre-Olivier; Rouprêt, Morgan

doi:10.1016/j.urolonc.2012.08.010

Cited by 36 publications

(30 citation statements)

References 26 publications

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“…Firstly, this was a retrospective study containing some bias. Secondly, the bladder recurrence rates in our study were relatively lower than those in previous studies, which is partly due to prophylactic intravesical instillation and excluding high-risk patients with contamination/previous bladder tumours (24)(25)(26). Thirdly, our centre evaluated Ki-67 and P53 expression prospectively, with limitations on consistency and with the reproducibility of IHC questionable.…”

Section: Discussionmentioning

confidence: 73%

Low-level Ki-67 expression as an independent predictor of bladder tumour recurrence in patients with primary upper tract urothelial carcinoma after radical nephroureterectomy

Liu

Zhang

et al. 2015

Jpn. J. Clin. Oncol.

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Objective: To evaluate the association of molecular markers and conventional clinicopathological factors with bladder tumour recurrence in patients with primary upper tract urothelial carcinoma after radical nephroureterectomy. Methods: The expressions of Ki-67 and P53 were measured by immunohistochemical staining prospectively in 115 consecutive patients with primary upper tract urothelial carcinoma from March 2004 to February 2014. The Cox proportional hazards regression model was used to identify independent predictors. The association between Ki-67 expression and clinicopathological variables was assessed by the χ 2 test.Results: Intravesical recurrence occurred in 13 out of 115 (11.3%) patients with a mean follow-up of 54.2 months (range: 7-130). Low-level Ki-67 expression (P = 0.010), older age (>65, P = 0.040) and lower ureter tumour (P = 0.001) were independent predictors of bladder tumour recurrence in Cox regression analysis. Ki-67 expression was elevated with the progression of tumour grade (P = 0.004) but not with stage (P = 0.186). Ki-67 overexpression was also significantly higher in aggressive pathological types (P = 0.008), but only shows an inclination towards poor oncologic outcomes in the cancer-specific survival rate (P = 0.107) and the overall survival rate (P = 0.063).Conclusions: Low-level Ki-67 expression was an independent predictor for bladder tumour recurrence, while Ki-67 overexpression was associated with adverse clinicopathological parameters and poor prognosis in patients with primary upper tract urothelial carcinoma after radical nephroureterectomy.

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Section: Discussionmentioning

confidence: 73%

Low-level Ki-67 expression as an independent predictor of bladder tumour recurrence in patients with primary upper tract urothelial carcinoma after radical nephroureterectomy

Liu

Zhang

et al. 2015

Jpn. J. Clin. Oncol.

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“…On estime que : environ 12 à 30 % des patients avec une TVES ont un antécédent de tumeur de la vessie, environ 8 à 13 % ont une localisation vésicale synchrone et enfin 11 % ont à la fois un antécédent de localisation vésicale et une localisation vésicale concomittante au diagnostic de TVES [4,18,19].…”

Section: Prévalence De La Maladie Urothéliale Localisation Vésicale Aunclassified

Épidémiologie et facteurs de risque des tumeurs de la voie excrétrice urinaire supérieure : revue de la littérature pour le rapport annuel de l’Association française d’urologie

Ouzzane

Rouprêt

Leon³

et al. 2014

Progrès en Urologie

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“…However, this remains a matter of debate. In our results, the previously considered prognostic factors of DURS [17], tumor stage, grade, size [23], LVI [24], location [4,5,13], adjuvant chemotherapy [14], and synchronous bladder cancer [16] were not associated significantly with bladder recurrence. However, the presence of DM, cortical thinning, GPS, and performance status were suggested to be independent prognostic parameters for bladder recurrence.…”

Section: Discussionmentioning

confidence: 42%

“…To date, several studies have identified possible risk factors for subsequent intravesical recurrence in patients treated surgically for UTUC [3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24]. Proposed risk factors include tumor configuration, tumor multifocality, tumor stage and grade, tumor location, tumor size, lymphovascular invasion (LVI), patient gender, adjuvant chemotherapy, preoperative urine cytology, synchronous bladder cancer, diagnostic ureteroscopy (DURS), hydronephrosis, and diabetes mellitus (DM).…”

Section: Introductionmentioning

confidence: 99%

Predictors of Intravesical Recurrence After Radical Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma: An Inflammation-Based Prognostic Score

et al. 2014

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PurposeSystemic inflammatory responses, which are defined in terms of the Glasgow prognostic score (GPS), have been reported to be independent predictors of unfavorable outcomes in various human cancers. We assessed the utility of the GPS as a predictor of intravesical recurrence after radical nephroureterectomy (RNU) in upper urinary tract carcinoma (UTUC).Materials and MethodsWe collected data for 147 UTUC patients with no previous history of bladder cancer who underwent RNU from 2004 to 2012. Associations between perioperative clinicopathological variables and intravesical recurrence were analyzed by using univariate and multivariate Cox regression models.ResultsOverall, 71 of 147 patients (48%) developed intravesical recurrence, including 21 patients (30%) diagnosed with synchronous bladder tumor. In the univariate analysis, performance status, diabetes mellitus (DM), serum albumin, C-reactive protein, GPS, and synchronous bladder tumor were associated with intravesical recurrence. In the multivariate analysis, performance status (hazard ratio [HR], 2.33; 95% confidence interval [CI], 1.41-3.85; p=0.001), DM (HR, 2.04; 95% CI, 1.21-3.41; p=0.007), cortical thinning (HR, 2.01; 95% CI, 1.08-3.71; p=0.026), and GPS (score of 1: HR, 6.86; 95% CI, 3.69-12.7; p=0.001; score of 2: HR, 5.96; 95% CI, 3.10-11.4; p=0.001) were independent predictors of intravesical recurrence.ConclusionsOur results suggest that the GPS as well as performance status, DM, and cortical thinning are associated with intravesical recurrence after RNU. Thus, more careful follow-up, coupled with postoperative intravesical therapy to avoid bladder recurrence, should be considered in these patients.

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Influence of previous or synchronous bladder cancer on oncologic outcomes after radical nephroureterectomy for upper urinary tract urothelial carcinoma

Cited by 36 publications

References 26 publications

Low-level Ki-67 expression as an independent predictor of bladder tumour recurrence in patients with primary upper tract urothelial carcinoma after radical nephroureterectomy

Low-level Ki-67 expression as an independent predictor of bladder tumour recurrence in patients with primary upper tract urothelial carcinoma after radical nephroureterectomy

Épidémiologie et facteurs de risque des tumeurs de la voie excrétrice urinaire supérieure : revue de la littérature pour le rapport annuel de l’Association française d’urologie

Predictors of Intravesical Recurrence After Radical Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma: An Inflammation-Based Prognostic Score

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