Influence of probiotics, included in peanut butter, on the fate of selected <i>Salmonella</i>
 and <i>Listeria</i>
 strains under simulated gastrointestinal conditions

Klu, Yaa Asantewaa Kafui; Chen, J.

doi:10.1111/jam.13084

Cited by 10 publications

(8 citation statements)

References 26 publications

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“…Enterococcus faecalis conjugated with a bacteriocin-expressing plasmid pPD1 effectively outcompetes strains without the plasmid and inhibits growth of multidrug-resistant enterococci. 101 Similar results have been found in the ability of bacteriocin-producing bacteria to inhibit various Streptococcus species, 102 Salmonella enteritidis, 103 Listeria monocytogenes, 104 and Clostridioides difficile. [105][106][107] A related approach was taken by Kim et al who investigated the effectiveness of a four-strained consortium of commensal bacteria (Clostridium bolteae, Blautia producta, Bacteroides sartorii, and Parabacteroides distasonis) at providing resistance to VRE, a common ICU pathogen, in mice.…”

Section: Novel Approaches To Pathogen Colonizationsupporting

confidence: 70%

Section: Novel Approaches To Pathogen Colonizationsupporting

confidence: 70%

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Impact of microbiome-based interventions on gastrointestinal pathogen colonization in the intensive care unit

Choy

Freedberg

2020

Therap Adv Gastroenterol

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In the intensive care unit (ICU), colonization of the gastrointestinal tract by potentially pathogenic bacteria is common and often precedes clinical infection. Though effective in the short term, traditional antibiotic-based decolonization methods may contribute to rising resistance in the long term. Novel therapies instead focus on restoring gut microbiome equilibrium to achieve pathogen colonization resistance. This review summarizes the existing data regarding microbiome-based approaches to gastrointestinal pathogen colonization in ICU patients with a focus on prebiotics, probiotics, and synbiotics.

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Section: Novel Approaches To Pathogen Colonizationsupporting

confidence: 70%

Section: Novel Approaches To Pathogen Colonizationsupporting

confidence: 70%

Impact of microbiome-based interventions on gastrointestinal pathogen colonization in the intensive care unit

Choy

Freedberg

2020

Therap Adv Gastroenterol

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“…Probiotics can also alter the intestinal lumen/mucosal barrier environment by secreting lactic acid, peroxides, and antimicrobial substances (e.g., toxins) impacting microbiome composition. A laboratory culture of 10 Lactobacillus and 5 Bifidobacterium strains inhibited pathogen growth of 3 Salmonella and 3 Listeria strains by secreting lactic acid, which decreased pH levels, and secreting bacteriocin, a peptidic toxin that inhibits bacteria growth(104). Spent media from a Lactobacilli crispatus culture containing H 2 O 2 inhibited the growth of Staphylococcus aureus which was attributed to the oxidative effect of H 2 O 2 or its metabolites (OH − ; O 2- )(105).…”

Section: Strengthening the Mucus Barriermentioning

confidence: 99%

Engineering the Mucus Barrier

Carlson

Lock

2018

Annu. Rev. Biomed. Eng.

114

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Mucus selectively controls the transport of molecules, particulate matter, and microorganisms to the underlying epithelial layer. It may be desirable to weaken the mucus barrier to enable effective delivery of drug carriers. Alternatively, the mucus barrier can be strengthened to prevent epithelial interaction with pathogenic microbes or other exogenous materials. The dynamic mucus layer can undergo changes in structure (e.g., pore size) and/or composition (e.g., protein concentrations, mucin glycosylation) in response to stimuli that occur naturally or are purposely administered, thus altering its barrier function. This review outlines mechanisms by which mucus provides a selective barrier and methods to engineer the mucus layer from the perspective of strengthening or weakening its barrier properties. In addition, we discuss strategic design of drug carriers and dosing formulation properties for efficient delivery across the mucus barrier.

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“…Antagonistic activity of the bacteriocin producers against a number of pathogenic or antibiotic-resistant bacterial strains in the gut has been a major focus of gut microbiota studies. Several LAB bacteriocins and/or bacteriocin-producing LAB have been shown to inhibit pathogens such as Listeria monocytogenes [83,84], Clostridium difficile [85–87], Staphylococcus aureus [88] and even Salmonella enteritidis [89], Some bacteriocin producers have also been reported to eliminate multidrug- or vancomycin-resistant enterococci [81,90]. Therefore, the production of bacteriocins may contribute to the beneficial activities in the gut.…”

Section: Bacteriocinsmentioning

confidence: 99%

Modulation of the gut microbiota by prebiotic fibres and bacteriocins

Umu

Rudi

Diep

2017

Microbial Ecology in Health and Disease

101

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The gut microbiota is considered an organ that co-develops with the host throughout its life. The composition and metabolic activities of the gut microbiota are subject to a complex interplay between the host genetics and environmental factors, such as lifestyle, diet, stress and antimicrobials. It is evident that certain prebiotics, and antimicrobials produced by lactic acid bacteria (LAB), can shape the composition of the gut microbiota and its metabolic activities to promote host health and/or prevent diseases. In this review, we aim to give an overview of the impact of prebiotic fibres, and bacteriocins from LAB, on the gut microbiota and its activities, which affect the physiology and health of the host. These represent two different mechanisms in modulating the gut microbiota, the first involving exploitative competition by which the growth of beneficial bacteria is promoted and the latter involving interference competition by which the growth of pathogens and other unwanted bacteria is prevented. For interference competition in the gut, bacteriocins offer special advantages over traditional antibiotics, in that they can be designed to act towards specific unwanted bacteria and other pathogens, without any remarkable collateral effects on beneficial microbes sharing the same niche.

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Influence of probiotics, included in peanut butter, on the fate of selected Salmonella and Listeria strains under simulated gastrointestinal conditions

Abstract: Peanut butter is a plausible carrier to deliver probiotics to improve the gastrointestinal health of children in developing countries.

Cited by 10 publications

References 26 publications

Impact of microbiome-based interventions on gastrointestinal pathogen colonization in the intensive care unit

Impact of microbiome-based interventions on gastrointestinal pathogen colonization in the intensive care unit

Engineering the Mucus Barrier

Modulation of the gut microbiota by prebiotic fibres and bacteriocins

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