Influence of process conditions on the product properties in a continuous fluidized bed spray granulation process

Diez, E.; Meyer, Katja; Bück, Andreas; Tsotsas, Evangelos; Heinrich, Stefan

doi:10.1016/j.cherd.2018.09.032

Cited by 39 publications

(12 citation statements)

References 39 publications

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Section: Previous Workmentioning

confidence: 99%

“…The continuous granulation of sodium benzoate in a horizontal fluidized bed with sieve-milling circuit was investigated by Diez et al (2018). Similar to and Hoffmann et al (2015), Diez et al (2018) produced particles with a compact and smooth surface at high air temperatures and low liquid spray rates, whereas low temperatures and high spray rates resulted in a higher surface roughness. Schmidt et al (2017) performed coating experiments with γ-Al 2 O 3 particles and a suspension of limestone, hydroxy propyl methyl cellulose and water at different atomization pressures of the top-spray nozzle used for the injection of the suspension.…”

Section: Previous Workmentioning

confidence: 99%

See 1 more Smart Citation

Correlating Granule Surface Structure Morphology and Process Conditions in Fluidized Bed Layering Spray Granulation

Orth

Kieckhefen

Pietsch

et al. 2022

KONA

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A workflow for developing a multidimensional, linear correlation between the process conditions during fluidized bed spray granulation and the surface morphology of the resulting granules is presented. Spray coating experiments with Cellets ® 500 particles and sodium benzoate solution were performed in a lab-scale fluidized bed varying liquid spray rate, fluidization air flow rate, fluidization air temperature, spray air temperature and spray atomization pressure. To characterize the surface structure, the surface roughness of the coated particles was quantified using confocal laser-scanning microscopy. The roughness was correlated to the process conditions, and the resulting correlation was rigorously analyzed for the importance and co-linearities of the individual process parameters using a principal component analysis. The surface roughness is strongly dependent on the spray rate of the coating solution, the fluidization air temperature and the atomization pressure at the nozzle. In general, wet process conditions and large droplets with a low initial velocity favor the formation of particles with a rough surface structure, while dry conditions and fine droplets with a high velocity result in granules with a smooth and compact coating layer.

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Section: Previous Workmentioning

confidence: 99%

Section: Previous Workmentioning

confidence: 99%

Correlating Granule Surface Structure Morphology and Process Conditions in Fluidized Bed Layering Spray Granulation

Orth

Kieckhefen

Pietsch

et al. 2022

KONA

View full text Add to dashboard Cite

show abstract

“…• extension of mathematical models for single process units, where such effects like influence of the thermal conditions onto granule morphology will be considered [64];…”

Section: Linking Process and Product Modelsmentioning

confidence: 99%

Flowsheet simulation of solids processes: Current status and future trends

Dosta

Litster

Heinrich

2020

Advanced Powder Technology

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Complex manufacturing processes are nowadays applied for production of various solid products. It is very common that for production of particles with desired properties several transformation steps like drying, milling, classification, granulation, etc. should be involved. This leads to the process structures consisting of different apparatuses or transformation substeps connected with material and energy balances. Consequently, development of new processes or optimization of already existing, as well as an optimal control, is a very challenging task, which can be partially solved using numerical modelling.For the simulation of modern production processes, the flowsheet calculations can be effectively used. Starting from the 80s a lot of work focused on the flowsheet simulation of liquid-vapor systems has been done and as result various well-established systems exist today. With respect to the solid processes the intensive research has been started much later.In this contribution we present our view about a current role of flowsheet simulation for modeling of particulate materials and specify the open fields which can be covered in future research.

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“…The mill is assumed to be mass‐conserving with a normal size distribution of the milled particles with mean μ mill and variance

σ_{mill}^{2}

. As reported in , the particle comminution also depends on the particle porosity, which was not considered so far, but may affect process stability and is therefore crucial for the design of an appropriate control strategy, since stability is the primary objective of any control concept.…”

Section: Mathematical Modelmentioning

confidence: 99%

Control of Particle Size and Porosity in Continuous Fluidized‐Bed Layering Granulation Processes

Neugebauer

Bück²,

Kienle

2020

Chem Eng & Technol

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Particle formulation processes such as continuous fluidized-bed layering granulation (FBLG) are widely applied in chemical, food, and pharmaceutical industries. Particle size and particle porosity are important product properties in FBLG. In this paper, a new concept is presented for the simultaneous control of both properties. The new concept allows stable process operation, automatic adjustment of the desired product properties, and rejection of unforseen disturbances.

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Influence of process conditions on the product properties in a continuous fluidized bed spray granulation process

Cited by 39 publications

References 39 publications

Correlating Granule Surface Structure Morphology and Process Conditions in Fluidized Bed Layering Spray Granulation

Correlating Granule Surface Structure Morphology and Process Conditions in Fluidized Bed Layering Spray Granulation

Flowsheet simulation of solids processes: Current status and future trends

Control of Particle Size and Porosity in Continuous Fluidized‐Bed Layering Granulation Processes

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