This paper reports an intelligent approach for modeling and optimisation of filling system design (FSD) in the case of sand casting process of aluminium alloy. In order to achieve this purpose, physics-based process modeling using finite element method (FEM) has been integrated with artificial neural networks (ANN) and genetic algorithm (GA) soft computing techniques. A threedimensional FE model of the studied process has been developed and validated, using experimental literature data, to predict two melt flow behaviour (MFB) indexes named ingate velocity and jet high. Two feed-forward back-propagation ANN-based process models were developed and optimised to establish the relationship between the FSD input parameters and each studied MFB index. Both ANN models were trained, tested and tuned by using database generated from FE computations. It was found that both ANN models could independently predict, with a high accuracy, the values of the ingate velocity and the jet high for training and test data. The developed ANN models were coupled with an evolutionary GA to select the optimal FSD for each one. The validity of the found solutions was tested by comparing ANN-GA prediction with FE computation for both studied MFB indexes. It was found that error between predicted and simulated values does not exceed 5.61% and 6.31% respectively for the ingate velocity and the jet high, which proves that the proposed approach is reliable and robust for FSD optimisation.