Influence of Propionibacterium avidum KP-40 on the proliferation, maturation, emigration and activity of thymocytes and monocytes

Ko, H.L.; Winkler, Carl; Beuth, Josef; Tunggal, Lucy; Buss, G.; Jeljaszewicz, J.; Klippel, K. F.; Pulverer, G.

doi:10.1016/s0934-8840(11)80800-5

Cited by 3 publications

(4 citation statements)

References 11 publications

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“…Bacteriocin production is then manifested by zones of growth inhibition around the colony. The first reports on PAB bacteriocins concerned bacteriocins from cutaneous propionibacteria [8,17,28]. Bacteriocin production among "classical" or "dairy" PAB was first studied by Grinstead [11].…”

Section: Screening For Bacteriocin Activitymentioning

confidence: 99%

Bacteriocins of propionic acid bacteria

Holo¹,

Faye²,

Brede³

et al. 2002

Lait

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-Dairy propionibacteria produce a number of inhibitory compounds like propionate, acetate and diacetyl. In addition, a number of strains produce bacteriocins. Unlike lactic acid bacteria, they often produce compounds that inhibit Gram (-) bacteria as well as yeasts and molds. These dairy propionibacteria are food-grade organisms and their bacteriocins may be of interest as food preservatives. Some of their bacteriocins have been characterized. Most are heat-stable peptides containing less than 100 amino acid residues. They are insensitive to large variations in pH, and lactic acid bacteria are often more sensitive to the bacteriocins than propionibacteria. However, at present only bacteriocins with inhibitory spectra restricted to propionibacteria have been fully sequenced. Most of the bacteriocins are produced in very low amounts when the cells are grown in liquid culture, which limits their usefulness in practical applications.

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Section: Screening For Bacteriocin Activitymentioning

confidence: 99%

Bacteriocins of propionic acid bacteria

Holo¹,

Faye²,

Brede³

et al. 2002

Lait

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“…The higher activity for C. avidum was confirmed in parallel with antitumor activity by Cummins and Linn (23). Later, the Pulverer group demonstrated the ability of C. avidum KP-40 (a strain included in Pulverer group patent CA1197798A) to potentially modify and enhance thymocyte/lymphocyte proliferation, maturation, emigration, and activation (21).…”

Section: Immune Stimulationmentioning

confidence: 86%

“…The key role played by propionibacteria in modulating the immune response has been reported based on different approaches. Indeed, the three main species, including C. avidum, were described to be immunomodifiers stimulating the different cell subset populations implicated in nonspecific antibacterial, antiviral, and antitumor resistances (21). The higher activity for C. avidum was confirmed in parallel with antitumor activity by Cummins and Linn (23).…”

Section: Immune Stimulationmentioning

confidence: 99%

“…Later, following various studies, the key role played by Cutibacterium species, especially C. avidum, in immune response modulation was demonstrated (20). Indeed, this species has been reported to be an immunomodifier, stimulating the various cell subset populations involved in nonspecific antibacterial, antiviral, or antitumor abilities (21).…”

Section: Introductionmentioning

confidence: 99%

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Clinical and Biological Features of Cutibacterium (Formerly Propionibacterium)avidum, an Underrecognized Microorganism

Corvec

2018

Clin Microbiol Rev

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The recent description of the genus has altered the taxonomy of species. These organisms still belong to the genera of the skin coryneform group, and the most-studied species remains . is also a known skin commensal. This underrecognized microorganism can, however, act as a pathogen after bacterial seeding and can be considered opportunistic, causing either superficial or deep/invasive infections. It can cause numerous infections, including but not limited to breast infections, skin abscesses, infective endocarditis, and device-related infections. The ecological niche of is clearly different from that of other members of the genus: it is found in the axillary region or at wet sites rather than in dry, exposed areas, and the number of microorganisms increases during puberty. Historically, it has been used for its ability to modulate the immune response and for its antitumor properties. Conventional microbial culture methods and identification processes allow for its accurate identification and characterization. Thanks to the modern omics tools used for phylogenomic approaches, understanding pathogenesis (including host-bacterium interactions and virulence factor characterization) is becoming easier, allowing for more thorough molecular characterization. These analyses have revealed that causes diverse diseases mediated by multiple virulence factors. The recent genome approach has revealed specific genomic regions within this species that are involved in adherence and biofilm formation as well as fitness, survival, and defense functions. Numerous regions show the presence of phages and horizontal gene transfer. remains highly sensitive to a broad spectrum of antibiotics, such as β-lactams, fluoroquinolones, macrolides, and rifampin, although erythromycin and clindamycin resistance has been described. A long-term treatment regimen with a combination of antibiotics is required to successfully eliminate the remaining adherent bacteria, particularly in the case of deep infections after debridement surgery.

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The Cutaneous Propionibacteria

Holland

Bojar

2002

Molecular Medical Microbiology

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Influence of Propionibacterium avidum KP-40 on the proliferation, maturation, emigration and activity of thymocytes and monocytes

Cited by 3 publications

References 11 publications

Bacteriocins of propionic acid bacteria

Bacteriocins of propionic acid bacteria

Clinical and Biological Features of Cutibacterium (Formerly Propionibacterium)avidum, an Underrecognized Microorganism

The Cutaneous Propionibacteria

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