Influence of Prostatic Edema on 131Cs Permanent Prostate Seed Implants: A Dosimetric and Radiobiological Study

Kehwar, Than S.; Jones, Heather; Huq, M. Saiful; Smith, Ryan P.

doi:10.1016/j.ijrobp.2010.07.001

Cited by 6 publications

(11 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another important factor is prostate edema [16][17][18][19][20] which is proportional to the number of needle insertion/manipulation and number of needle used. Waterman et al investigated extensively the effects of edema on dose distribution using 125 I and 103 Pd seeds, and suggested to incorporate these effects in dosimetric plans.…”

Section: Introductionmentioning

confidence: 99%

“…16,17 Kehwar et al have suggested that the effect of edema must be accounted for when defining the seed positions, to avoid the possibility of poor dosimetric and radiobiologic results for 131 Cs seed implants. 18 Bucci et al reported that the amount of postimplant edema demon-strated a significant effect on the risk of urinary obstructive symptoms. 19 The range of edema has been nicely summarized in the report of the AAPM TG-137.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A novel curvilinear approach for prostate seed implantation

et al. 2012

View full text Add to dashboard Cite

Significant improvement in the relevant dosimetric parameters was observed in curvilinear needle approach. Prostate dose homogeneity (V(150), V(200)) improved while urethral dose was reduced, which might potentially result in better treatment outcome. Reduction in rectal dose could potentially reduce rectal toxicity and complications. Reduction in number of needles would minimize edema and thereby could improve postimplant urinary incontinence. This study indicates that the curvilinear implantation approach is dosimetrically superior to conventional rectilinear implantation technique.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A novel curvilinear approach for prostate seed implantation

et al. 2012

View full text Add to dashboard Cite

show abstract

“…However, the needle introduction into the peripheral area is challenging puncturing prostate capsule away from central axis, increased needle obliquity angle, inadequacy/non rigidity in supporting of the prostate and single point proximalend actuation of a long slender needle (Nag et al, 2000). Another important factor is the swelling of the prostate during brachytherapy (Kehwar et al, 2011;Nath et al, 74 2009). Eapen et al (2004) discovered that the prostate trauma due to the needle insertion makes a significant contribution to the development of acute urogenital toxicity.…”

Section: Theoretical Background and Literature Reviewmentioning

confidence: 99%

The Existing Methods for Motion Control of Flexible Needles along a Curved Path as Part of Robotic Systems for Brachytherapy

Lopota¹,

Gryaznov²,

Velichko³

et al. 2016

American Journal of Applied Sciences

View full text Add to dashboard Cite

Review of the recent developments in steerable needles and control algorithms of their movements in curvilinear directions in the human body for the modern robotic system to perform brachytherapy in prostate cancer patients is presented. Advantages of steerable needles over the standard ones are described; design aspects of these needles and results of the phantom studies are discussed. Scientific novelty consists in structuring the research information on the newest approaches in the prostate cancer treatment using brachytherapy, about the methods and tools that improve the quality of procedures, reducing time of procedure and making it safer.

show abstract

“…Recently, 131 Cs seeds have been implemented in many centers across USA, including our institution. (1)(2)(3) The design of 131 Cs seed is similar to that of 125 I and 103 Pd, but has a shorter half-life of 9.7 days, and slightly higher average photon energy than 125 I and 103 Pd. (4)(5)(6) The shorter half-life of 131 Cs can induce differences between planned and delivered doses due to prostatic edema, thus potentially impacting values of dosimetric and radiobiological quantities of interest.…”

Section: Introductionmentioning

confidence: 99%

“…Since 131 Cs is a relatively new radioactive source used for prostate permanent seed implants, a number of studies have been done to investigate the effect on edema of 131 Cs permanent seed implants. (2,3,(7)(8)(9)(10)(11) In a recent study, we derived prostate volume changes after prostate brachytherapy from its original volume using US and CT images acquired at day 0, day 14, and day 28 after implant, and found that the prostate edema resolves exponentially with postimplant time. (2) The exponential decay of prostatic edema induces a significant amount of change in dosimetric and radiobiological quantities in 131 Cs implants due to its short half-life of 9.7 days.…”

Section: Introductionmentioning

confidence: 99%

Edema‐induced changes in tumor cell surviving fraction and tumor control probability in permanent prostate brachytherapy implant patients

Kehwar

Jones

Huq

et al. 2013

J Applied Clin Med Phys

Self Cite

View full text Add to dashboard Cite

The study is designed to investigate the effect of edema on the delivered dose, tumor cell surviving fraction (SF), and tumor control probability (TCP) in the patients of prostate cancer who underwent 131Cs permanent seed implantation. The dose reduction, the SF, and the TCP for edematous prostate implants were calculated for 31 patients who underwent real‐time 131Cs permanent seed implantation for edema half‐lives (EHL), ranging from 4 days to 34 days and for edema magnitudes (normalM0) varying from 5% to 60% of the actual prostate volume. A dose reduction in 131Cs implants varied from 1.1% (for EHL=4 days and normalM0=5%) to 32.3% (for EHL=34 days and normalM0=60%). These are higher than the dose reduction in 125normalI implants, which vary from 0.3% (for EHL=4 days and normalM0=5%) to 17.5% (for EHL=34 days and normalM0=60%). As EHL increased from 4 days to 34 days and edema magnitude increased from 5% to 60%, the natural logarithmic value of SF increased by 4.57 and the TCP decreased by 0.80. Edema induced increase in the SF and decrease in the TCP in 131Cs seed implants, is significantly more pronounced in a combination of higher edema magnitude and larger edema half‐lives than for less edema magnitude and lower edema half‐lives, as compared for normalM0=60% and EHL=34, and normalM0=5% and EHL=4 days.PACS number: 87.53.Jw

show abstract

Influence of Prostatic Edema on 131Cs Permanent Prostate Seed Implants: A Dosimetric and Radiobiological Study

Cited by 6 publications

References 33 publications

A novel curvilinear approach for prostate seed implantation

A novel curvilinear approach for prostate seed implantation

The Existing Methods for Motion Control of Flexible Needles along a Curved Path as Part of Robotic Systems for Brachytherapy

Edema‐induced changes in tumor cell surviving fraction and tumor control probability in permanent prostate brachytherapy implant patients

Contact Info

Product

Resources

About