Influence of Psychological Stress on Upper Respiratory Infection—A Meta-Analysis of Prospective Studies

Pedersen, Anette Fischer; Zachariae, Robert; Bovbjerg, Dana H.

doi:10.1097/psy.0b013e3181f1d003

Cited by 118 publications

(87 citation statements)

References 65 publications

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“…[14][15][16][17]. This association has been replicated in cross-sectional and prospective studies conducted in natural settings (18). Although attempts to identify behavioral pathways linking stress to cold susceptibility have not been especially successful (14,15), there is evidence consistent with stress effects resulting in increased disease risk because of their association with exaggerated local (in the nose) release of inflammatory cytokines (16).…”

mentioning

confidence: 77%

Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk

Cohen

Janicki-Deverts

Doyle

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

1,059

782

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We propose a model wherein chronic stress results in glucocorticoid receptor resistance (GCR) that, in turn, results in failure to downregulate inflammatory response. Here we test the model in two viral-challenge studies. In study 1, we assessed stressful life events, GCR, and control variables including baseline antibody to the challenge virus, age, body mass index (BMI), season, race, sex, education, and virus type in 276 healthy adult volunteers. The volunteers were subsequently quarantined, exposed to one of two rhinoviruses, and followed for 5 d with nasal washes for viral isolation and assessment of signs/symptoms of a common cold. In study 2, we assessed the same control variables and GCR in 79 subjects who were subsequently exposed to a rhinovirus and monitored at baseline and for 5 d after viral challenge for the production of local (in nasal secretions) proinflammatory cytokines (IL-1β, TNF-α, and IL-6). Study 1: After covarying the control variables, those with recent exposure to a long-term threatening stressful experience demonstrated GCR; and those with GCR were at higher risk of subsequently developing a cold. Study 2: With the same controls used in study 1, greater GCR predicted the production of more local proinflammatory cytokines among infected subjects. These data provide support for a model suggesting that prolonged stressors result in GCR, which, in turn, interferes with appropriate regulation of inflammation. Because inflammation plays an important role in the onset and progression of a wide range of diseases, this model may have broad implications for understanding the role of stress in health.lymphocytes | receptor sensitivity | psychological stress | cortisol | hypothalamic-pituitary-adrenocortical axis

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mentioning

confidence: 77%

Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk

Cohen

Janicki-Deverts

Doyle

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

1,059

782

View full text Add to dashboard Cite

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“…Stress has been implicated as a risk factor in cardiovascular disease (Richardson et al,15 2012), the progression of HIV/AIDS (Remor et al, 2007), wound healing response (Broadbent et al, 2012), upper respiratory infections (Pedersen et al, 2010) and autoimmune diseases (Porcelli et al, 2016). Stress may directly interfere with the regulation of immune and inflammatory processes.…”

Section: Introductionmentioning

confidence: 99%

How financial strain affects health: Evidence from the Dutch National Bank Household Survey

Prentice

McKillop

French

2017

Social Science & Medicine

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The mechanisms by which financial strain affects health are not well understood. In this paper, we conduct a longitudinal mediation analysis of the Dutch National Bank 5Household Survey. To quantify the relative importance of biological and nonbiological pathways from financial strain to health, we consider smoking, heavy drinking and being overweight as plausible behavioural responses to financial strain but find that only 4.9% of the response of self-reported health to financial strain is mediated by these behaviours. Further analysis indicates that although financial strain increases 10 impulsivity this has little effect on unhealthy behaviours. Economic stresses therefore appear to be distinct from other forms of stress in the relatively minor influence of nonbiological pathways to ill-health.

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“…While acute infections elicit a short-term immune response, latent infections such as herpesviruses, are never cleared from the body (Glaser and Kiecolt-Glaser, 1994;Pedersen et al, 2010;Uddin et al, 2010) and have been shown to reactivate over time-particularly in response to stress (Glaser and Kiecolt-Glaser, 1994). Reactivation has, in turn, been hypothesized to trigger increased production of antibodies specific for such pathogens (Dowd et al, 2008(Dowd et al, , 2012Christian et al, 2012;Rector et al, 2014), and contribute to elevated levels of circulating pro-inflammatory cytokines such as Creactive protein and interleukin-6 (Nazmi et al, 2010;Bennett et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Use of Archived Neonatal Bloodspots for Examining Associations between Prenatal Exposure to Potentially Traumatic or Stressful Life Events, Maternal Herpesvirus Infection and Lifetime History of Generalized Anxiety Disorder in Offspring

Simanek

Uddin

Yolken³

et al. 2016

Front. Environ. Sci.

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Background: Lifetime prevalence of anxiety disorders is over 30% among U.S. adolescents, warranting further investigation into early life risk factors for such conditions. We conducted a pilot study to examine the role that maternal herpesvirus infection may play in the pathway between maternal trauma and stress during pregnancy and offspring generalized anxiety disorder (GAD).Methods: Participants included 69 women in the Detroit Neighborhood Health Study with data on past exposure to 19 potentially traumatic (PTEs) and 9 stressful life events (SLEs). Lifetime history of GAD in the youngest biologic child between 6 and 17 years old born in Michigan (i.e., index child) of each woman was ascertained via the Diagnostic Interview Schedule for Children, 4th edition, parent version. We obtained written informed consent from participants for retrieval of archived neonatal bloodspot samples corresponding to their index child from the Michigan Neonatal Biobank (MNB) and testing of these samples for markers of maternal herpes simplex virus (HSV)-1 and cytomegalovirus (CMV) seropositivity. Logistic regression was used to examine the association between maternal PTEs or SLEs during pregnancy and offspring GAD.Results: A total of 18.1 and 31.9% of women experienced ≥1 PTE or SLE during pregnancy, respectively, and 10.8% of offspring met the criteria for lifetime history of GAD. We obtained maternal consent for retrieval of and tested bloodspot samples corresponding to the index child of 22 women (38.0%), of which 4.5 and 40.9% were seropositive for HSV-1 and CMV, respectively. We observed positive, although not statistically significant associations between ≥1 PTE or SLE during pregnancy and offspring lifetime history of GAD. While a greater proportion of offspring with lifetime Simanek et al. Prenatal Trauma, Herpesviruses Offspring GAD history of GAD were born to women seropositive for CMV and HSV-1, compared to those without lifetime history, these differences were not statistically significant and we did not further examine the mediating role of maternal herpesvirus seropositivity in this pathway. Conclusion:Findings from this study support the feasibility of utilizing neonatal bloodspots archived in the MNB to examine the role of herpesviruses as mediators between maternal trauma or stress during pregnancy and offspring anxiety disorders in larger Michigan cohorts.

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Influence of Psychological Stress on Upper Respiratory Infection—A Meta-Analysis of Prospective Studies

Abstract: The meta-analytical findings confirmed the hypothesis that psychological stress is associated with increased susceptibility to URI, lending support to an emerging appreciation of the potential importance of psychological factors in infectious disease.

Cited by 118 publications

References 65 publications

Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk

Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk

How financial strain affects health: Evidence from the Dutch National Bank Household Survey

Use of Archived Neonatal Bloodspots for Examining Associations between Prenatal Exposure to Potentially Traumatic or Stressful Life Events, Maternal Herpesvirus Infection and Lifetime History of Generalized Anxiety Disorder in Offspring

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