Influence of Pulmonary Dust Load on the Development of Experimental Infection by Mycobacterium kansasii

Policard, A; Gernez-Rieux, C; Tacquet, A; Martin, Jean-Charles; Devulder, B; Bouffant, L. Le

doi:10.1038/216177a0

Cited by 15 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, tuberculosis is still in great excess in South African gold miners and slate workers in Wales (22)(23)(24). The depressant effect of crystalline silica on the ability of alveolar macrophages to kill the tuberculosis mycobacterium was confirmed in experimental studies (25). It is believed that silicosis leads to a reduction in cell-mediated immunity with alterations in lymphocyte subsets and serum immunoglobulin levels (26).…”

Section: Silicosis and Tuberculosismentioning

confidence: 88%

Silicosis and coal workers' pneumoconiosis.

Castranova

Vallyathan

2000

Environ Health Perspect

309

176

View full text Add to dashboard Cite

Exposure to coal mine dust and/or crystalline silica results in pneumoconiosis with initiation and progression of pulmonary fibrosis. This review presents characteristics of simple and complicated coal workers' pneumoconiosis (CWP) as well as pathologic indices of acute and chronic silicosis by summarizing results of in vitro, animal, and human investigations. These results support four basic mechanisms in the etiology of CWP and silicosis: a) direct cytotoxicity of coal dust or silica, resulting in lung cell damage, release of lipases and proteases, and eventual lung scarring; b) activation of oxidant production by pulmonary phagocytes, which overwhelms the antioxidant defenses and leads to lipid peroxidation, protein nitrosation, cell injury, and lung scarring; c) activation of mediator release from alveolar macrophages and epithelial cells, which leads to recruitment of polymorphonuclear leukocytes and macrophages, resulting in the production of proinflammatory cytokines and reactive species and in further lung injury and scarring; o) secretion of growth factors from alveolar macrophages and epithelial cells, stimulating fibroblast proliferation and eventual scarring. Results of in vitro and animal studies provide a basis for proposing these mechanisms for the initiation and progression of pneumoconiosis. Data obtained from exposed workers lend support to these mechanisms.

show abstract

Section: Silicosis and Tuberculosismentioning

confidence: 88%

Silicosis and coal workers' pneumoconiosis.

Castranova

Vallyathan

2000

Environ Health Perspect

309

176

View full text Add to dashboard Cite

show abstract

“…kansasii has an association with mining and pneumoconiosis in other regions of the world (6)(7)(8), and pathogenicity in experimental animals can be increased by preexposure to coal and silica dust (9). Although M. scrofulaceum has rarely been described as a cause of pulmonary disease elsewhere (6), marked regional variation in the predominant pathogens is a general feature of NTM disease epidemiology (7).…”

Section: Discussionmentioning

confidence: 99%

Nontuberculous Mycobacteria

Corbett

Blumberg

Churchyard

et al. 1999

Am J Respir Crit Care Med

View full text Add to dashboard Cite

A gold mining work force was followed prospectively over 1 yr for sputum nontuberculous mycobacterial (NTM) isolates. NTM were isolated from 118 men, of whom 32 (27%) met the American Thoracic Society (ATS) case-definitions for pulmonary NTM disease (23 M. kansasii, seven M. scrofulaceum, one M. avium, and one M. abscessus). Determining isolate significance was difficult because most men had been started on presumptive TB treatment before isolate identification (70%). Histologic criteria were considered inappropriate for this high M. tuberculosis incidence population, particularly for patients who had stabilized on presumptive TB treatment. Among men not meeting case-definitions, indicators of disease were significantly more prevalent for M. kansasii than for M. fortuitum, the local laboratory contaminant (ORs: 6.5 for cough, 7. 2 for smear-positivity, 36.0 for radiologic changes, and 14.3 for presumptive TB treatment), suggesting underdiagnosis of M. kansasii disease. Of 53 men with definite or possible M. kansasii disease, 18 (34%) were HIV-positive. HIV-associated M. kansasii disease occurred at an early stage of immunosuppression (median CD4 count, 381 x 10(6)/L) with a good outcome (83% cured after 12 mo of treatment). ATS case-definitions for NTM disease are difficult to apply in this population, and treatment decisions should be guided by the pathogenic potential of the isolate.

show abstract

“…In the animal study reported in 1967, guinea-pigs were infected with M. kansasii via an intravenous route under the dusty conditions of coal and quartz. [21] This experiment demonstrated that dust increased the pulmonary infection. Furthermore, as dust deposits in the lungs increased, the extent of lung lesions increased with a linear relationship.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for developing Mycobacterium kansasii lung disease

Kim¹,

Seo²,

Shin

et al. 2019

Medicine

View full text Add to dashboard Cite

Previous studies have suggested that development of Mycobacterium kansasii lung disease (MKLD) was associated with COPD, pneumoconiosis, aging, male, immunosuppression, alcohol, malignancy, and certain occupations such as mining and sandblasting. However, previous studies were outdated and used non-comparative statistical methods. We aimed to determine the current risk factors for developing MKLD in Korea by using appropriate statistical techniques. Eighty-six MKLD patients were identified through a search of the Ulsan University Hospital database between January 2010 and December 2014. These cases were matched with 172 controls who had normal respiratory systems in a health examination during the same period (matching variables, age and sex; case: control ratio of 1:2). Clinical and demographic characteristics were gathered by reviewing the medical record and telephone survey. Multivariate logistic regression analyses were performed to evaluate risk factors for developing MKLD. Multivariate analysis showed that occupation in heavy industries (adjusted odds ratio (aOR) 6.41, 95% confidence interval (CI) 2.19−18.74, P = .001) and low body mass index (BMI) (aOR [per kg/m 2 ] 0.73, 95% CI 0.63−0.85, P < .001) were independent risk factors for development of MKLD. Educational attainment more than high school was associated with a lower risk of MKLD development (aOR 0.22, 95% CI 0.08−0.63, P = .005). Employees in heavy industry and low BMI are independent risk factors for development of MKLD in Korea.

show abstract

Influence of Pulmonary Dust Load on the Development of Experimental Infection by Mycobacterium kansasii

Cited by 15 publications

References 4 publications

Silicosis and coal workers' pneumoconiosis.

Silicosis and coal workers' pneumoconiosis.

Nontuberculous Mycobacteria

Risk factors for developing Mycobacterium kansasii lung disease

Contact Info

Product

Resources

About