Influence of quercetin and rutin on growth and antioxidant defense system of a human hepatoma cell line (HepG2)

Alía, Mario; Mateos, Raquel; Ramos, Sonia; Lecumberri, Elena; Bravo, Laura; Goya, Luis

doi:10.1007/s00394-005-0558-7

Cited by 224 publications

(177 citation statements)

References 43 publications

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“…Quercetin and rutin also induced beneficial changes in the antioxidant defence system in HepG2 cells, since both flavonoids prevented or delayed conditions which favoured cellular oxidative stress [41]. Nevertheless, quercetin showed a stronger protector effect of cells against an oxidative insult than its glycoside rutin.…”

Section: Antioxidantmentioning

confidence: 99%

“…Additionally to the mentioned natural defence mechanisms of the cell, dietary polyphenols can also act as antioxidants, preventing injury caused by free radicals and blocking the initiation step of cancer [4,41,42]. In more detail, polyphenolic compounds can prevent the DNA-damage caused by free radicals or carcinogenic agents through different mechanisms: (i) direct radical scavenging [41,43], (ii) chelating divalent cations involved in Fenton reaction [44] and (iii) modulation of enzymes related to oxidative stress (glutathione peroxidase (GPx), glutathione reductase (GR), SOD, nitricoxide sinthase, lipooxygenase, xanthine oxidase, etc.) [41,45] ( Table 3).…”

Section: Antioxidantmentioning

confidence: 99%

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Cancer chemoprevention and chemotherapy: Dietary polyphenols and signalling pathways

Ramos¹

2008

Molecular Nutrition Food Res

627

499

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Prevention of cancer through dietary intervention recently has received an increasing interest, and dietary polyphenols have become not only important potential chemopreventive, but also therapeutic, natural agents. Polyphenols have been reported to interfere at the initiation, promotion and progression of cancer. They might lead to the modulation of proteins in diverse pathways and require the integration of different signals for the final chemopreventive or therapeutic effect. Polyphenols have been demonstrated to act on multiple key elements in signal transduction pathways related to cellular proliferation, differentiation, apoptosis, inflammation, angiogenesis and metastasis; however, these molecular mechanisms of action are not completely characterized and many features remain to be elucidated. The aim of this review is to provide insights into the molecular basis of potential chemopreventive and therapeutic activities of dietary polyphenols with emphasis in their ability to control intracellular signalling cascades considered as relevant targets in a cancer preventive approach.

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Section: Antioxidantmentioning

confidence: 99%

Section: Antioxidantmentioning

confidence: 99%

Cancer chemoprevention and chemotherapy: Dietary polyphenols and signalling pathways

Ramos¹

2008

Molecular Nutrition Food Res

627

499

View full text Add to dashboard Cite

show abstract

“…Other researchers have documented that HepG2 cells are a well-differentiated, transformed cell line for antioxidant studies [29] and yield consistent results with lower variation than other cell lines, including Caco-2 and RAW 264.7 cells [28].…”

Section: + - or H 2 O 2 -Induced Oxidative Stress In Hepg2 Cellsmentioning

confidence: 99%

Effects of Heat Processing Time on Total Phenolic Content and Antioxidant Capacity of Ginseng Jung Kwa

Oh¹,

Kim²,

Lee³

et al. 2010

Journal of Ginseng Research

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Korean ginseng (Panax ginseng C.A. Meyer) preserved in syrup, known as ginseng Jung Kwa (GJK), is a popular traditional snack in Korea. We investigated the effects of heat processing time on total phenolic content and antioxidant capacity of GJK. Water extract was prepared from GJK with different heat processing times, 3 hours (GJK-3), 6 hours (GJK-6), or 12 hours (GJK-12), with sonication for 2 hours. The GJK extract contained total phenolic content in the following order: GJK-12 (2.28%) > GJK-6 (1.57%) > GJK-3 (1.29%). Both the peroxy and hydroxyl radical-scavenging activity and cellular antioxidant capacity of GJK extract was significantly enhanced with increasing heat processing time. The hydroxyl radicalscavenging activity of GJK-12 extract was greater than that of the GJK-3 and GJK-6 extracts, consistent with metal chelating capacity and reducing capacity. In a cellular model, the GJK extract effectively reduced 2,2'-azobis(2-amidinopropane) dihydrochloride, Cu 2+ -, and H 2 O 2 -induced oxidative stress, with GJK-12 and GJK-6 extracts demonstrating greater cellular antioxidant capacity than the GJK-3 extract. These results suggest that heat processing time can contribute to the antioxidant capacity of GJK and that GJK extract may have the potential to be used as an effective dietary antioxidant to prevent oxidative stress-related diseases.

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“…Transition metal complexes with N, S donor ligands as synthetic antioxidants: Synthesis, characterization and antioxidant activity [24][25][26][27] However, antioxidant supplements or dietary antioxidants may be sources of protection that the body needs to protect against the damaging effects of free radicals. 28 Presently, synthetic antioxidants are widely used because they are effective and cheaper than natural antioxidants.…”

Section: Original Articlementioning

confidence: 99%

Transition metal complexes with N, S donor ligands as synthetic antioxidants: Synthesis, characterization and antioxidant activity

Choudhary

Sharma

Nagar

et al. 2010

Journal of Enzyme Inhibition and Medicinal Chemistry

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Influence of quercetin and rutin on growth and antioxidant defense system of a human hepatoma cell line (HepG2)

Abstract: The results indicate that both natural antioxidants induce favorable changes in the antioxidant defense system of cultured HepG2 that prevent or delay conditions which favor cellular oxidative stress.

Cited by 224 publications

References 43 publications

Cancer chemoprevention and chemotherapy: Dietary polyphenols and signalling pathways

Cancer chemoprevention and chemotherapy: Dietary polyphenols and signalling pathways

Effects of Heat Processing Time on Total Phenolic Content and Antioxidant Capacity of Ginseng Jung Kwa

Transition metal complexes with N, S donor ligands as synthetic antioxidants: Synthesis, characterization and antioxidant activity

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